Host Factors and Biomarkers Associated with Poor Outcomes in Adults with Invasive Pneumococcal Disease
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"Host factors and biomarkers associated with poor outcomes in adults with invasive pneumococcal disease", "type"=>"journal", "authors"=>[{"first_name"=>"Shigeo", "last_name"=>"Hanada", "scopus_author_id"=>"36439422000"}, {"first_name"=>"Satoshi", "last_name"=>"Iwata", "scopus_author_id"=>"55427356500"}, {"first_name"=>"Kazuma", "last_name"=>"Kishi", "scopus_author_id"=>"35451520500"}, {"first_name"=>"Miyuki", "last_name"=>"Morozumi", "scopus_author_id"=>"7005548539"}, {"first_name"=>"Naoko", "last_name"=>"Chiba", "scopus_author_id"=>"7102331472"}, {"first_name"=>"Takeaki", "last_name"=>"Wajima", "scopus_author_id"=>"25823532200"}, {"first_name"=>"Misako", "last_name"=>"Takata", "scopus_author_id"=>"57117209600"}, {"first_name"=>"Kimiko", "last_name"=>"Ubukata", "scopus_author_id"=>"7006771162"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84958191095", "pui"=>"608273596", "doi"=>"10.1371/journal.pone.0147877", "isbn"=>"1932-6203", "sgr"=>"84958191095", "pmid"=>"26815915"}, "id"=>"d33af209-fba1-3e39-b1df-39f5e358f1a0", "abstract"=>"BACKGROUND: Invasive pneumococcal disease (IPD) causes considerable morbidity and mortality. We aimed to identify host factors and biomarkers associated with poor outcomes in adult patients with IPD in Japan, which has a rapidly-aging population.\\n\\nMETHODS: In a large-scale surveillance study of 506 Japanese adults with IPD, we investigated the role of host factors, disease severity, biomarkers based on clinical laboratory data, treatment regimens, and bacterial factors on 28-day mortality.\\n\\nRESULTS: Overall mortality was 24.1%, and the mortality rate increased from 10.0% in patients aged ˂50 years to 33.1% in patients aged ≥80 years. Disease severity also increased 28-day mortality, from 12.5% among patients with bacteraemia without sepsis to 35.0% in patients with severe sepsis and 56.9% with septic shock. The death rate within 48 hours after admission was high at 54.9%. Risk factors for mortality identified by multivariate analysis were as follows: white blood cell (WBC) count <4000 cells/μL (odds ratio [OR], 6.9; 95% confidence interval [CI], 3.7-12.8, p < .001); age ≥80 years (OR, 6.5; 95% CI, 2.0-21.6, p = .002); serum creatinine ≥2.0 mg/dL (OR, 4.5; 95% CI, 2.5-8.1, p < .001); underlying liver disease (OR, 3.5; 95% CI, 1.6-7.8, p = .002); mechanical ventilation (OR, 3.0; 95% CI, 1.7-5.6, p < .001); and lactate dehydrogenase ≥300 IU/L (OR, 2.4; 95% CI, 1.4-4.0, p = .001). Pneumococcal serotype and drug resistance were not associated with poor outcomes.\\n\\nCONCLUSIONS: Host factors, disease severity, and biomarkers, especially WBC counts and serum creatinine, were more important determinants of mortality than bacterial factors.", "link"=>"http://www.mendeley.com/research/host-factors-biomarkers-associated-poor-outcomes-adults-invasive-pneumococcal-disease", "reader_count"=>23, "reader_count_by_academic_status"=>{"Student > Doctoral Student"=>3, "Researcher"=>3, "Student > Postgraduate"=>1, "Other"=>2, "Student > Master"=>14}, "reader_count_by_user_role"=>{"Student > Doctoral Student"=>3, "Researcher"=>3, "Student > Postgraduate"=>1, "Other"=>2, "Student > Master"=>14}, "reader_count_by_subject_area"=>{"Medicine and Dentistry"=>19, "Agricultural and Biological Sciences"=>2, "Sports and Recreations"=>1, "Biochemistry, Genetics and Molecular Biology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>19}, "Sports and Recreations"=>{"Sports and Recreations"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}}, "reader_count_by_country"=>{"Japan"=>1, "United Kingdom"=>1}, "group_count"=>3}

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84958191095"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84958191095?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84958191095&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84958191095&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/84958191095", "dc:identifier"=>"SCOPUS_ID:84958191095", "eid"=>"2-s2.0-84958191095", "dc:title"=>"Host factors and biomarkers associated with poor outcomes in adults with invasive pneumococcal disease", "dc:creator"=>"Hanada S.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"11", "prism:issueIdentifier"=>"1", "prism:pageRange"=>nil, "prism:coverDate"=>"2016-01-01", "prism:coverDisplayDate"=>"1 January 2016", "prism:doi"=>"10.1371/journal.pone.0147877", "citedby-count"=>"6", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Keio University", "affiliation-city"=>"Tokyo", "affiliation-country"=>"Japan"}, {"@_fa"=>"true", "affilname"=>"Toranomon Hospital", "affiliation-city"=>"Tokyo", "affiliation-country"=>"Japan"}, {"@_fa"=>"true", "affilname"=>"Okinaka Memorial Institute for Medical Research", "affiliation-city"=>"Tokyo", "affiliation-country"=>"Japan"}], "pubmed-id"=>"26815915", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e0147877", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0147877", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Counter

  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"31", "xml_views"=>"3", "html_views"=>"81"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"21", "xml_views"=>"0", "html_views"=>"128"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"73"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"55"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"39"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"40"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"32"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"34"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"39"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"34"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"40"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"0", "xml_views"=>"1", "html_views"=>"13"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"38"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"133"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"233"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"11"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"4", "html_views"=>"6"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"21"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"16"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"7"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"7"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"8"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"9"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"3"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"3"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/4288630"], "description"=>"<p>Risk factors associated with mortality within 28 days among patients with invasive pneumococcal disease by multivariate logistic regression analysis.</p>", "links"=>[], "tags"=>["mortality", "IPD", "Invasive Pneumococcal Disease BackgroundInvasive pneumococcal disease", "disease severity", "CI", "WBC", "host factors", "IU", "biomarker"], "article_id"=>2636848, "categories"=>["Medicine", "Microbiology", "Cell Biology", "Biotechnology", "Immunology", "Biological Sciences not elsewhere classified", "Developmental Biology", "Cancer", "Infectious Diseases", "Virology", "Computational Biology"], "users"=>["Shigeo Hanada", "Satoshi Iwata", "Kazuma Kishi", "Miyuki Morozumi", "Naoko Chiba", "Takeaki Wajima", "Misako Takata", "Kimiko Ubukata"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0147877.t003", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Risk_factors_associated_with_mortality_within_28_days_among_patients_with_invasive_pneumococcal_disease_by_multivariate_logistic_regression_analysis_/2636848", "title"=>"Risk factors associated with mortality within 28 days among patients with invasive pneumococcal disease by multivariate logistic regression analysis.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2016-01-27 05:40:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/4288618"], "description"=>"<p><b>(A)</b> Patients with leukopenia on admission had a higher risk for death, compared to patients without leukopenia. The majority of deaths occurred within the first 5 days after admission to the hospital (<i>p</i> < .001 by the log-rank test). WBC, white blood cell count. <b>(B)</b> Patients with severe sepsis or septic shock compared to patients with bacteraemia without sepsis or sepsis on admission. Mortality increased with severity of sepsis (<i>p</i> < .001 by the log-rank test).</p>", "links"=>[], "tags"=>["mortality", "IPD", "Invasive Pneumococcal Disease BackgroundInvasive pneumococcal disease", "disease severity", "CI", "WBC", "host factors", "IU", "biomarker"], "article_id"=>2636836, "categories"=>["Medicine", "Microbiology", "Cell Biology", "Biotechnology", "Immunology", "Biological Sciences not elsewhere classified", "Developmental Biology", "Cancer", "Infectious Diseases", "Virology", "Computational Biology"], "users"=>["Shigeo Hanada", "Satoshi Iwata", "Kazuma Kishi", "Miyuki Morozumi", "Naoko Chiba", "Takeaki Wajima", "Misako Takata", "Kimiko Ubukata"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0147877.g003", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Kaplan_Meier_estimate_of_the_probability_of_28_day_survival_/2636836", "title"=>"Kaplan-Meier estimate of the probability of 28-day survival.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-01-27 05:40:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/4288606"], "description"=>"<p>Case fatality rates by age groups and disease severity.</p>", "links"=>[], "tags"=>["mortality", "IPD", "Invasive Pneumococcal Disease BackgroundInvasive pneumococcal disease", "disease severity", "CI", "WBC", "host factors", "IU", "biomarker"], "article_id"=>2636824, "categories"=>["Medicine", "Microbiology", "Cell Biology", "Biotechnology", "Immunology", "Biological Sciences not elsewhere classified", "Developmental Biology", "Cancer", "Infectious Diseases", "Virology", "Computational Biology"], "users"=>["Shigeo Hanada", "Satoshi Iwata", "Kazuma Kishi", "Miyuki Morozumi", "Naoko Chiba", "Takeaki Wajima", "Misako Takata", "Kimiko Ubukata"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0147877.g001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Case_fatality_rates_by_age_groups_and_disease_severity_/2636824", "title"=>"Case fatality rates by age groups and disease severity.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-01-27 05:40:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/4288624"], "description"=>"<p>Characteristics of adults with invasive pneumococcal disease associated with fatal outcome.</p>", "links"=>[], "tags"=>["mortality", "IPD", "Invasive Pneumococcal Disease BackgroundInvasive pneumococcal disease", "disease severity", "CI", "WBC", "host factors", "IU", "biomarker"], "article_id"=>2636842, "categories"=>["Medicine", "Microbiology", "Cell Biology", "Biotechnology", "Immunology", "Biological Sciences not elsewhere classified", "Developmental Biology", "Cancer", "Infectious Diseases", "Virology", "Computational Biology"], "users"=>["Shigeo Hanada", "Satoshi Iwata", "Kazuma Kishi", "Miyuki Morozumi", "Naoko Chiba", "Takeaki Wajima", "Misako Takata", "Kimiko Ubukata"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0147877.t001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Characteristics_of_adults_with_invasive_pneumococcal_disease_associated_with_fatal_outcome_/2636842", "title"=>"Characteristics of adults with invasive pneumococcal disease associated with fatal outcome.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2016-01-27 05:40:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/4288585", "https://ndownloader.figshare.com/files/4288588", "https://ndownloader.figshare.com/files/4288591", "https://ndownloader.figshare.com/files/4288594"], "description"=>"<div><p>Background</p><p>Invasive pneumococcal disease (IPD) causes considerable morbidity and mortality. We aimed to identify host factors and biomarkers associated with poor outcomes in adult patients with IPD in Japan, which has a rapidly-aging population.</p><p>Methods</p><p>In a large-scale surveillance study of 506 Japanese adults with IPD, we investigated the role of host factors, disease severity, biomarkers based on clinical laboratory data, treatment regimens, and bacterial factors on 28-day mortality.</p><p>Results</p><p>Overall mortality was 24.1%, and the mortality rate increased from 10.0% in patients aged ˂50 years to 33.1% in patients aged ≥80 years. Disease severity also increased 28-day mortality, from 12.5% among patients with bacteraemia without sepsis to 35.0% in patients with severe sepsis and 56.9% with septic shock. The death rate within 48 hours after admission was high at 54.9%. Risk factors for mortality identified by multivariate analysis were as follows: white blood cell (WBC) count <4000 cells/μL (odds ratio [OR], 6.9; 95% confidence interval [CI], 3.7–12.8, <i>p</i> < .001); age ≥80 years (OR, 6.5; 95% CI, 2.0–21.6, <i>p</i> = .002); serum creatinine ≥2.0 mg/dL (OR, 4.5; 95% CI, 2.5–8.1, <i>p</i> < .001); underlying liver disease (OR, 3.5; 95% CI, 1.6–7.8, <i>p</i> = .002); mechanical ventilation (OR, 3.0; 95% CI, 1.7–5.6, <i>p</i> < .001); and lactate dehydrogenase ≥300 IU/L (OR, 2.4; 95% CI, 1.4–4.0, <i>p</i> = .001). Pneumococcal serotype and drug resistance were not associated with poor outcomes.</p><p>Conclusions</p><p>Host factors, disease severity, and biomarkers, especially WBC counts and serum creatinine, were more important determinants of mortality than bacterial factors.</p></div>", "links"=>[], "tags"=>["mortality", "IPD", "Invasive Pneumococcal Disease BackgroundInvasive pneumococcal disease", "disease severity", "CI", "WBC", "host factors", "IU", "biomarker"], "article_id"=>2636812, "categories"=>["Medicine", "Microbiology", "Cell Biology", "Biotechnology", "Immunology", "Biological Sciences not elsewhere classified", "Developmental Biology", "Cancer", "Infectious Diseases", "Virology", "Computational Biology"], "users"=>["Shigeo Hanada", "Satoshi Iwata", "Kazuma Kishi", "Miyuki Morozumi", "Naoko Chiba", "Takeaki Wajima", "Misako Takata", "Kimiko Ubukata"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0147877.s001", "https://dx.doi.org/10.1371/journal.pone.0147877.s002", "https://dx.doi.org/10.1371/journal.pone.0147877.s003", "https://dx.doi.org/10.1371/journal.pone.0147877.s004"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Host_Factors_and_Biomarkers_Associated_with_Poor_Outcomes_in_Adults_with_Invasive_Pneumococcal_Disease/2636812", "title"=>"Host Factors and Biomarkers Associated with Poor Outcomes in Adults with Invasive Pneumococcal Disease", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2016-01-27 05:40:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/4288627"], "description"=>"<p>Laboratory findings associated with fatal outcome in adults with invasive pneumococcal disease.</p>", "links"=>[], "tags"=>["mortality", "IPD", "Invasive Pneumococcal Disease BackgroundInvasive pneumococcal disease", "disease severity", "CI", "WBC", "host factors", "IU", "biomarker"], "article_id"=>2636845, "categories"=>["Medicine", "Microbiology", "Cell Biology", "Biotechnology", "Immunology", "Biological Sciences not elsewhere classified", "Developmental Biology", "Cancer", "Infectious Diseases", "Virology", "Computational Biology"], "users"=>["Shigeo Hanada", "Satoshi Iwata", "Kazuma Kishi", "Miyuki Morozumi", "Naoko Chiba", "Takeaki Wajima", "Misako Takata", "Kimiko Ubukata"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0147877.t002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Laboratory_findings_associated_with_fatal_outcome_in_adults_with_invasive_pneumococcal_disease_/2636845", "title"=>"Laboratory findings associated with fatal outcome in adults with invasive pneumococcal disease.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2016-01-27 05:40:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/4288612"], "description"=>"<p>Distribution of deaths in patients with invasive pneumococcal disease in relation to the time elapsed after admission to the hospital.</p>", "links"=>[], "tags"=>["mortality", "IPD", "Invasive Pneumococcal Disease BackgroundInvasive pneumococcal disease", "disease severity", "CI", "WBC", "host factors", "IU", "biomarker"], "article_id"=>2636830, "categories"=>["Medicine", "Microbiology", "Cell Biology", "Biotechnology", "Immunology", "Biological Sciences not elsewhere classified", "Developmental Biology", "Cancer", "Infectious Diseases", "Virology", "Computational Biology"], "users"=>["Shigeo Hanada", "Satoshi Iwata", "Kazuma Kishi", "Miyuki Morozumi", "Naoko Chiba", "Takeaki Wajima", "Misako Takata", "Kimiko Ubukata"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0147877.g002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Distribution_of_deaths_in_patients_with_invasive_pneumococcal_disease_in_relation_to_the_time_elapsed_after_admission_to_the_hospital_/2636830", "title"=>"Distribution of deaths in patients with invasive pneumococcal disease in relation to the time elapsed after admission to the hospital.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-01-27 05:40:59"}

PMC Usage Stats | Further Information

  • {"unique-ip"=>"39", "full-text"=>"37", "pdf"=>"16", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"27", "full-text"=>"35", "pdf"=>"17", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"17", "full-text"=>"17", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"13", "full-text"=>"9", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"14", "full-text"=>"15", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"17", "full-text"=>"17", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"15", "full-text"=>"14", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"8", "full-text"=>"6", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"10", "full-text"=>"13", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"9", "full-text"=>"10", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"12", "full-text"=>"8", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"15", "full-text"=>"16", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"8", "full-text"=>"10", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"10", "full-text"=>"12", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"12", "full-text"=>"13", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"7", "full-text"=>"9", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"4", "full-text"=>"5", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"12", "full-text"=>"15", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"5", "full-text"=>"3", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}

Relative Metric

{"start_date"=>"2016-01-01T00:00:00Z", "end_date"=>"2016-12-31T00:00:00Z", "subject_areas"=>[]}
Loading … Spinner
There are currently no alerts