High-Fat Diet Changes Hippocampal Apolipoprotein E (ApoE) in a Genotype- and Carbohydrate-Dependent Manner in Mice
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{"title"=>"High-Fat Diet Changes Hippocampal Apolipoprotein e (ApoE) in a Genotype- and Carbohydrate-Dependent Manner in Mice", "type"=>"journal", "authors"=>[{"first_name"=>"Courtney", "last_name"=>"Lane-Donovan", "scopus_author_id"=>"56368270000"}, {"first_name"=>"Joachim", "last_name"=>"Herz", "scopus_author_id"=>"7102447359"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"608335305", "pmid"=>"26828652", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0148099", "isbn"=>"1932-6203", "scopus"=>"2-s2.0-84958741542", "sgr"=>"84958741542"}, "id"=>"df7a1e0a-2921-303b-8bb0-e1b6da892c17", "abstract"=>"Alzheimer's disease is a currently incurable neurodegenerative disease affecting millions of individuals worldwide. Risk factors for Alzheimer's disease include genetic risk factors, such as possession of ε4 allele of apolipoprotein E (ApoE4) over the risk-neutral ApoE3 allele, and lifestyle risk factors, such as diet and exercise. The intersection of these two sources of disease risk is not well understood. We investigated the impact of diet on ApoE levels by feeding wildtype, ApoE3, and ApoE4 targeted replacement (TR) mice with chow, high-fat, or ketogenic (high-fat, very-low-carbohydrate) diets. We found that high-fat diet affected both plasma and hippocampal levels of ApoE in an isoform-dependent manner, with high-fat diet causing a surprising reduction of hippocampal ApoE levels in ApoE3 TR mice. Conversely, the ketogenic diet had no effect on hippocampal ApoE. Our findings suggest that the use of dietary interventions to slow the progression AD should take ApoE genotype into consideration.", "link"=>"http://www.mendeley.com/research/highfat-diet-changes-hippocampal-apolipoprotein-e-apoe-genotype-carbohydratedependent-manner-mice", "reader_count"=>33, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>2, "Student > Doctoral Student"=>5, "Researcher"=>6, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>1, "Student > Master"=>3, "Other"=>1, "Student > Bachelor"=>7, "Lecturer"=>2, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>2, "Student > Doctoral Student"=>5, "Researcher"=>6, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>1, "Student > Master"=>3, "Other"=>1, "Student > Bachelor"=>7, "Lecturer"=>2, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Environmental Science"=>1, "Biochemistry, Genetics and Molecular Biology"=>6, "Medicine and Dentistry"=>7, "Agricultural and Biological Sciences"=>8, "Neuroscience"=>3, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Sports and Recreations"=>1, "Physics and Astronomy"=>1, "Psychology"=>2, "Social Sciences"=>1, "Computer Science"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>7}, "Neuroscience"=>{"Neuroscience"=>3}, "Social Sciences"=>{"Social Sciences"=>1}, "Sports and Recreations"=>{"Sports and Recreations"=>1}, "Physics and Astronomy"=>{"Physics and Astronomy"=>1}, "Psychology"=>{"Psychology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>8}, "Computer Science"=>{"Computer Science"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>6}, "Unspecified"=>{"Unspecified"=>1}, "Environmental Science"=>{"Environmental Science"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"Sweden"=>1, "United States"=>1, "Spain"=>1}, "group_count"=>3}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/4222276"], "description"=>"<p><b>A.)</b> Plasma ApoE levels after 5 weeks on a high-fat or chow diet in wildtype, ApoE3 TR, and ApoE4 TR mice. WT:chow (n = 15), WT:HFD (n = 9), ApoE3:chow (n = 14), ApoE3:HFD (n = 7), ApoE4:chow (n = 16), ApoE4:HFD (n = 7). <b>B.)</b> Hippocampal ApoE levels after 5 weeks on a high-fat or chow diet in wildtype, ApoE3 TR, and ApoE4 TR mice. For all genotypes on HFD, n = 6. WT:chow (n = 12), ApoE3:chow (n = 12), ApoE4:chow (n = 13). Data are shown as mean ± S.E.M. (* = p < 0.05, ** = p < 0.01, *** = p < 0.001, **** = p < 0.0001).</p>", "links"=>[], "tags"=>["ApoE genotype", "ApoE 4", "lifestyle risk factors", "Risk factors", "ketogenic diet", "risk factors", "hippocampal ApoE", "neurodegenerative disease", "hippocampal levels", "ApoE 3 TR mice", "apolipoprotein E", "disease risk", "ApoE levels", "progression AD", "hippocampal ApoE levels"], "article_id"=>2578354, "categories"=>["Genetics", "Molecular Biology", "Neuroscience", "Biotechnology", "Chemical Sciences not elsewhere classified", "Biological Sciences not elsewhere classified", "Cancer", "Science Policy", "Mental Health"], "users"=>["Courtney Lane-Donovan", "Joachim Herz"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0148099.g001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Effect_of_high_fat_diet_on_plasma_and_hippocampal_ApoE_/2578354", "title"=>"Effect of high-fat diet on plasma and hippocampal ApoE.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-02-01 12:55:50"}
  • {"files"=>["https://ndownloader.figshare.com/files/4222303"], "description"=>"<p><b>A.)</b> Plasma ApoE levels after a 5 week ketogenic or chow diet in wildtype. WT:chow (n = 15), WT:keto (n = 6), ApoE3:chow (n = 14), ApoE3: keto (n = 4), ApoE4:chow (n = 16), ApoE4/E4 keto (n = 6). <b>B.)</b> Hippocampal ApoE levels after 5 weeks on ketogenic or chow diet. WT:chow (n = 6), WT:keto (n = 12), ApoE3:chow (n = 6), ApoE3: keto (n = 6), ApoE4: chow (n = 13), ApoE4: keto (n = 7). (**** = p < 0.0001). The data are shown as mean ± S.E.M.</p>", "links"=>[], "tags"=>["ApoE genotype", "ApoE 4", "lifestyle risk factors", "Risk factors", "ketogenic diet", "risk factors", "hippocampal ApoE", "neurodegenerative disease", "hippocampal levels", "ApoE 3 TR mice", "apolipoprotein E", "disease risk", "ApoE levels", "progression AD", "hippocampal ApoE levels"], "article_id"=>2578372, "categories"=>["Genetics", "Molecular Biology", "Neuroscience", "Biotechnology", "Chemical Sciences not elsewhere classified", "Biological Sciences not elsewhere classified", "Cancer", "Science Policy", "Mental Health"], "users"=>["Courtney Lane-Donovan", "Joachim Herz"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0148099.g002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Effect_of_ketogenic_diet_on_plasma_and_hippocampal_ApoE_/2578372", "title"=>"Effect of ketogenic diet on plasma and hippocampal ApoE.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-02-01 12:55:50"}
  • {"files"=>["https://ndownloader.figshare.com/files/4222318"], "description"=>"<p>High-fat diet (HFD) induces weight gain in wildtype, ApoE3, and ApoE4 mice.</p>", "links"=>[], "tags"=>["ApoE genotype", "ApoE 4", "lifestyle risk factors", "Risk factors", "ketogenic diet", "risk factors", "hippocampal ApoE", "neurodegenerative disease", "hippocampal levels", "ApoE 3 TR mice", "apolipoprotein E", "disease risk", "ApoE levels", "progression AD", "hippocampal ApoE levels"], "article_id"=>2578378, "categories"=>["Genetics", "Molecular Biology", "Neuroscience", "Biotechnology", "Chemical Sciences not elsewhere classified", "Biological Sciences not elsewhere classified", "Cancer", "Science Policy", "Mental Health"], "users"=>["Courtney Lane-Donovan", "Joachim Herz"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0148099.t001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/High_fat_diet_HFD_induces_weight_gain_in_wildtype_ApoE3_and_ApoE4_mice_/2578378", "title"=>"High-fat diet (HFD) induces weight gain in wildtype, ApoE3, and ApoE4 mice.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2016-02-01 12:55:50"}
  • {"files"=>["https://ndownloader.figshare.com/files/4222327"], "description"=>"<p>Ketogenic diet induces weight loss in wildtype, ApoE3, and ApoE4 mice.</p>", "links"=>[], "tags"=>["ApoE genotype", "ApoE 4", "lifestyle risk factors", "Risk factors", "ketogenic diet", "risk factors", "hippocampal ApoE", "neurodegenerative disease", "hippocampal levels", "ApoE 3 TR mice", "apolipoprotein E", "disease risk", "ApoE levels", "progression AD", "hippocampal ApoE levels"], "article_id"=>2578381, "categories"=>["Genetics", "Molecular Biology", "Neuroscience", "Biotechnology", "Chemical Sciences not elsewhere classified", "Biological Sciences not elsewhere classified", "Cancer", "Science Policy", "Mental Health"], "users"=>["Courtney Lane-Donovan", "Joachim Herz"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0148099.t002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Ketogenic_diet_induces_weight_loss_in_wildtype_ApoE3_and_ApoE4_mice_/2578381", "title"=>"Ketogenic diet induces weight loss in wildtype, ApoE3, and ApoE4 mice.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2016-02-01 12:55:50"}

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Relative Metric

{"start_date"=>"2016-01-01T00:00:00Z", "end_date"=>"2016-12-31T00:00:00Z", "subject_areas"=>[]}
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