A Systematic Approach towards Optimizing a Cohabitation Challenge Model for Infectious Pancreatic Necrosis Virus in Atlantic Salmon (Salmo salar L.)
Publication Date
February 19, 2016
Journal
PLOS ONE
Authors
Hetron Mweemba Munang’andu, Nina Santi, Børge Nilsen Fredriksen, Knut Egil Løkling, et al
Volume
11
Issue
2
Pages
e0148467
DOI
https://dx.plos.org/10.1371/journal.pone.0148467
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0148467
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/26895162
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760736
Europe PMC
http://europepmc.org/abstract/MED/26895162
Web of Science
000371223400016
Scopus
84960976946
Mendeley
http://www.mendeley.com/research/systematic-approach-towards-optimizing-cohabitation-challenge-model-infectious-pancreatic-necrosis-v
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"A Systematic Approach towards Optimizing a Cohabitation Challenge Model for Infectious Pancreatic Necrosis Virus in Atlantic Salmon (Salmo salar L.)", "type"=>"journal", "authors"=>[{"first_name"=>"Hetron Mweemba", "last_name"=>"Munang’andu"}, {"first_name"=>"Nina", "last_name"=>"Santi"}, {"first_name"=>"Børge Nilsen", "last_name"=>"Fredriksen"}, {"first_name"=>"Knut-Egil", "last_name"=>"Løkling"}, {"first_name"=>"Øystein", "last_name"=>"Evensen"}], "year"=>2016, "source"=>"PLOS ONE", "identifiers"=>{"doi"=>"10.1371/journal.pone.0148467", "pmid"=>"26895162", "isbn"=>"1932-6203 (Electronic) 1932-6203 (Linking)", "issn"=>"1932-6203"}, "id"=>"862f66a5-7eb4-3582-b50a-86ccca821828", "abstract"=>"Abstract A cohabitation challenge model was developed for use in evaluating the efficacy of vaccines developed against infectious pancreatic necrosis virus (IPNV) in Atlantic salmon (Salmo salar L) using a stepwise approach. The study involved identifying a set of input variables that were optimized before inclusion in the model. Input variables identified included the highly virulent Norwegian Sp strain NVI015-TA encoding the T217A221 motif having the abil- ity to cause >90% mortality and a hazard risk ratio of 490.18 (p<0.000) for use as challenge virus. The challenge dose was estimated at 1x107 TCID50/mL per fish while the proportion of virus shedders was estimated at 12.5%of the total number of fish per tank. The model was designed based on a three parallel tank system in which the Cox hazard proportional regression model was used to estimate the minimum number of fish required to show signifi- cant differences between the vaccinated and control fish in each tank. All input variables were optimized to generate mortality >75% in the unvaccinated fish in order to attain a high discriminatory capacity (DC) between the vaccinated and control fish as a measure of vac- cine efficacy. The model shows the importance of using highly susceptible fish to IPNV in the optimization of challenge models by showing that highly susceptible fish had a better DC of differentiating vaccine protected fish from the unvaccinated control fish than the less susceptible fish. Once all input variables were optimized, the model was tested for its repro- ducibility by generating similar results from three independent cohabitation challenge trials using the same input variables. Overall, data presented here show that the cohabitation challenge model developed in this study is reproducible and that it can reliably be used to evaluate the efficacy of vaccines developed against IPNV in Atlantic salmon.We envision that the approach used here will open new avenues for developing optimal challenge mod- els for use in evaluating the efficacy of different vaccines used in aquaculture.", "link"=>"http://www.mendeley.com/research/systematic-approach-towards-optimizing-cohabitation-challenge-model-infectious-pancreatic-necrosis-v", "reader_count"=>14, "reader_count_by_academic_status"=>{"Researcher"=>3, "Student > Doctoral Student"=>1, "Student > Postgraduate"=>3, "Student > Master"=>1, "Other"=>1, "Student > Bachelor"=>2, "Lecturer"=>2, "Student > Ph. D. Student"=>1}, "reader_count_by_user_role"=>{"Researcher"=>3, "Student > Doctoral Student"=>1, "Student > Postgraduate"=>3, "Student > Master"=>1, "Other"=>1, "Student > Bachelor"=>2, "Lecturer"=>2, "Student > Ph. D. Student"=>1}, "reader_count_by_subject_area"=>{"Environmental Science"=>1, "Biochemistry, Genetics and Molecular Biology"=>2, "Agricultural and Biological Sciences"=>5, "Medicine and Dentistry"=>1, "Sports and Recreations"=>2, "Immunology and Microbiology"=>3}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Sports and Recreations"=>{"Sports and Recreations"=>2}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>3}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>5}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Environmental Science"=>{"Environmental Science"=>1}}, "reader_count_by_country"=>{"United Kingdom"=>1, "Chile"=>1}, "group_count"=>1}

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84960976946"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84960976946?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84960976946&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84960976946&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/84960976946", "dc:identifier"=>"SCOPUS_ID:84960976946", "eid"=>"2-s2.0-84960976946", "dc:title"=>"A systematic approach towards optimizing a cohabitation challenge model for infectious pancreatic necrosis virus in Atlantic salmon (Salmo salar L)", "dc:creator"=>"Munang'andu H.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"11", "prism:issueIdentifier"=>"2", "prism:pageRange"=>nil, "prism:coverDate"=>"2016-02-01", "prism:coverDisplayDate"=>"February 2016", "prism:doi"=>"10.1371/journal.pone.0148467", "citedby-count"=>"10", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Universitetet for miljø- og biovitenskap", "affiliation-city"=>"As", "affiliation-country"=>"Norway"}], "pubmed-id"=>"26895162", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e0148467", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0148467", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Counter

  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"402"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"77"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"32"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"39"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"37", "xml_views"=>"0", "html_views"=>"73"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"44", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"34", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"42", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"64", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"42", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"26", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"44"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"17", "xml_views"=>"1", "html_views"=>"17"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"20"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"35"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"30"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"129"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"243"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"9"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"8", "xml_views"=>"3", "html_views"=>"4"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"5", "html_views"=>"9"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"10"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"10"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"18"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"9"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"10"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"10"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"8"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"9"}
  • {"month"=>"10", "year"=>"2019", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"16"}
  • {"month"=>"11", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"7"}
  • {"month"=>"12", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"14"}
  • {"month"=>"1", "year"=>"2020", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"2", "year"=>"2020", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"6"}
  • {"month"=>"3", "year"=>"2020", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"4", "year"=>"2020", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"16"}
  • {"month"=>"5", "year"=>"2020", "pdf_views"=>"26", "xml_views"=>"1", "html_views"=>"8"}
  • {"month"=>"6", "year"=>"2020", "pdf_views"=>"8", "xml_views"=>"3", "html_views"=>"14"}
  • {"month"=>"7", "year"=>"2020", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"8", "year"=>"2020", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"2"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/4228588"], "description"=>"<p>Sampling time-point established for the cohabitation challenge model segmented into A and B. <b>(A)</b> shows the immune induction period (I and II), between vaccination and challenge, depicting the progression of antibody responses for fish immunized using a commercial vaccine (Pharmaq AS). Note that antibody responses increased by threefold from (I) during the early antibody responses when levels were at 0.326 OD<sub>490</sub> at 330 degree days (dd) to (II) pre-challenge antibody responses when levels were at 1.221 OD<sub>490</sub> at 672 dd. <b>(B)</b> shows the post challenge period depicting the progression of cumulative mortality in the vaccinated and control fish. Cumulative mortality for both the vaccinated and control fish progressed in three stages namely (III) lag-phase, (IV) exponential phase, and (V) plateau phase. Blue arrows below show the sampling time-points during immune induction and the post challenge period.</p>", "links"=>[], "tags"=>["challenge models", "Atlantic salmon", "cohabitation challenge trials", "Infectious Pancreatic Necrosis Virus", "Salmo salar L", "T 217A motif", "cohabitation challenge model", "Cohabitation Challenge Model", "vaccine", "hazard risk ratio", "input variables", "NVI", "pancreatic necrosis virus", "efficacy", "TCID", "IPNV", "DC", "unvaccinated control fish", "control fish"], "article_id"=>2582689, "categories"=>["Neuroscience", "Biotechnology", "Environmental Sciences not elsewhere classified", "Ecology", "Biological Sciences not elsewhere classified", "Cancer", "Inorganic Chemistry", "Infectious Diseases"], "users"=>["Hetron Mweemba Munang’andu", "Nina Santi", "Børge Nilsen Fredriksen", "Knut-Egil Løkling", "Øystein Evensen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0148467.g005", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Experimental_timing_/2582689", "title"=>"Experimental timing.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-02-19 14:40:24"}
  • {"files"=>["https://ndownloader.figshare.com/files/4228591"], "description"=>"<p>Shows a schematic design of a cohabitation challenge model based on a three parallel tank system with the number of fish estimated using the Cox PH regression model in which the statistical power function for sample size estimate was set at 80%, 95% CI and hazard risk (HR) ratio set 0.5. In each tank, 36 fish were vaccinated using a commercial vaccine (PHARMAQ AS, Oslo) and another 36 were injected with phosphate buffered saline (PBS) to serve as unvaccinated controls. After vaccination fish were kept at 12°C and left for smoltification. The study design was divided into immune induction, challenge period and convalescence stages. After smoltification, challenge was carried out by adding 9 virus shedders per tanks, which is 12.5% of the total number of fish per tank, and the virus shedders are injected with 1 x 10<sup>7</sup> TCID<sub>50</sub>/fish of strain NVI015-TA. The immune induction period was for evaluating immune responses prior to challenge while the challenge period enables evaluation of PCSP/RPS. The convalescence period covers the period after acute infection when fish stopped dying and enabled evaluation of post challenge recovery as well as assessing the number of virus carriers linked to persistent infections.</p>", "links"=>[], "tags"=>["challenge models", "Atlantic salmon", "cohabitation challenge trials", "Infectious Pancreatic Necrosis Virus", "Salmo salar L", "T 217A motif", "cohabitation challenge model", "Cohabitation Challenge Model", "vaccine", "hazard risk ratio", "input variables", "NVI", "pancreatic necrosis virus", "efficacy", "TCID", "IPNV", "DC", "unvaccinated control fish", "control fish"], "article_id"=>2582692, "categories"=>["Neuroscience", "Biotechnology", "Environmental Sciences not elsewhere classified", "Ecology", "Biological Sciences not elsewhere classified", "Cancer", "Inorganic Chemistry", "Infectious Diseases"], "users"=>["Hetron Mweemba Munang’andu", "Nina Santi", "Børge Nilsen Fredriksen", "Knut-Egil Løkling", "Øystein Evensen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0148467.g006", "stats"=>{"downloads"=>3, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Cohabitation_challenge_model_design_/2582692", "title"=>"Cohabitation challenge model design.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-02-19 14:40:24"}
  • {"files"=>["https://ndownloader.figshare.com/files/4228597"], "description"=>"<p>KM survival analysis for comparison of PCSP induced by strain NVI015-TA in the control fish challenged using a three parallel tank system described in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0148467#pone.0148467.g006\" target=\"_blank\">Fig 6</a>. Mortality in Tanks 1, 2 and 3 started at 19, 24, and 21 days post challenge, respectively. Overlaps in the KM survival curves for control fish from Tanks 1, 2 and 3 show that there was no statistical difference (p = 0.8223) in PCSPs for the three tanks.</p>", "links"=>[], "tags"=>["challenge models", "Atlantic salmon", "cohabitation challenge trials", "Infectious Pancreatic Necrosis Virus", "Salmo salar L", "T 217A motif", "cohabitation challenge model", "Cohabitation Challenge Model", "vaccine", "hazard risk ratio", "input variables", "NVI", "pancreatic necrosis virus", "efficacy", "TCID", "IPNV", "DC", "unvaccinated control fish", "control fish"], "article_id"=>2582698, "categories"=>["Neuroscience", "Biotechnology", "Environmental Sciences not elsewhere classified", "Ecology", "Biological Sciences not elsewhere classified", "Cancer", "Inorganic Chemistry", "Infectious Diseases"], "users"=>["Hetron Mweemba Munang’andu", "Nina Santi", "Børge Nilsen Fredriksen", "Knut-Egil Løkling", "Øystein Evensen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0148467.g007", "stats"=>{"downloads"=>1, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Mortality_in_non_vaccinated_controls_/2582698", "title"=>"Mortality in non-vaccinated controls.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-02-19 14:40:24"}
  • {"files"=>["https://ndownloader.figshare.com/files/4228567"], "description"=>"<p>Kaplan Meyer’s (KM) survival analysis of Atlantic salmon challenged using a high and low challenge dose carried out using strain NVI015-TA (Study II). (A) KM survival analysis for the high challenge dose (HC<sub>dose</sub>), 1x10<sup>7</sup> TCID<sub>50</sub>/fish. (B) KM survival analysis for the low challenge dose (LC<sub>dose</sub>), 1x10<sup>5</sup> TCID<sub>50</sub>/fish. Fig 1A shows a wider discriminatory capacity (DC>58%) compared to Fig 1B (DC = 40%) between the vaccinated and unvaccinated control fish.</p>", "links"=>[], "tags"=>["challenge models", "Atlantic salmon", "cohabitation challenge trials", "Infectious Pancreatic Necrosis Virus", "Salmo salar L", "T 217A motif", "cohabitation challenge model", "Cohabitation Challenge Model", "vaccine", "hazard risk ratio", "input variables", "NVI", "pancreatic necrosis virus", "efficacy", "TCID", "IPNV", "DC", "unvaccinated control fish", "control fish"], "article_id"=>2582668, "categories"=>["Neuroscience", "Biotechnology", "Environmental Sciences not elsewhere classified", "Ecology", "Biological Sciences not elsewhere classified", "Cancer", "Inorganic Chemistry", "Infectious Diseases"], "users"=>["Hetron Mweemba Munang’andu", "Nina Santi", "Børge Nilsen Fredriksen", "Knut-Egil Løkling", "Øystein Evensen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0148467.g001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/High_and_low_virus_challenge_dose_/2582668", "title"=>"High and low virus challenge dose.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-02-19 14:40:24"}
  • {"files"=>["https://ndownloader.figshare.com/files/4228600"], "description"=>"<p>Immunohistochemistry (IHC) of fish infected with strain NVI015-TA. Red stain shows presence of IPNV in the infected tissues. (A) Exocrine pancreas with condensed and pyknotic nuclei (A,B,C) are indicative of cellular degeneration and necrosis. (B) Liver with vacuolation (A) and cells with apoptotic nuclei (B) and necrotic liver cells (C).</p>", "links"=>[], "tags"=>["challenge models", "Atlantic salmon", "cohabitation challenge trials", "Infectious Pancreatic Necrosis Virus", "Salmo salar L", "T 217A motif", "cohabitation challenge model", "Cohabitation Challenge Model", "vaccine", "hazard risk ratio", "input variables", "NVI", "pancreatic necrosis virus", "efficacy", "TCID", "IPNV", "DC", "unvaccinated control fish", "control fish"], "article_id"=>2582701, "categories"=>["Neuroscience", "Biotechnology", "Environmental Sciences not elsewhere classified", "Ecology", "Biological Sciences not elsewhere classified", "Cancer", "Inorganic Chemistry", "Infectious Diseases"], "users"=>["Hetron Mweemba Munang’andu", "Nina Santi", "Børge Nilsen Fredriksen", "Knut-Egil Løkling", "Øystein Evensen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0148467.g008", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Immunohistochemistry_of_target_organs_/2582701", "title"=>"Immunohistochemistry of target organs.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-02-19 14:40:24"}
  • {"files"=>["https://ndownloader.figshare.com/files/4228603"], "description"=>"<p>Post challenge survival proportions and hazard ratios of different IPNV isolates used for selecting the challenge virus strain.</p>", "links"=>[], "tags"=>["challenge models", "Atlantic salmon", "cohabitation challenge trials", "Infectious Pancreatic Necrosis Virus", "Salmo salar L", "T 217A motif", "cohabitation challenge model", "Cohabitation Challenge Model", "vaccine", "hazard risk ratio", "input variables", "NVI", "pancreatic necrosis virus", "efficacy", "TCID", "IPNV", "DC", "unvaccinated control fish", "control fish"], "article_id"=>2582704, "categories"=>["Neuroscience", "Biotechnology", "Environmental Sciences not elsewhere classified", "Ecology", "Biological Sciences not elsewhere classified", "Cancer", "Inorganic Chemistry", "Infectious Diseases"], "users"=>["Hetron Mweemba Munang’andu", "Nina Santi", "Børge Nilsen Fredriksen", "Knut-Egil Løkling", "Øystein Evensen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0148467.t001", "stats"=>{"downloads"=>4, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Post_challenge_survival_proportions_and_hazard_ratios_of_different_IPNV_isolates_used_for_selecting_the_challenge_virus_strain_/2582704", "title"=>"Post challenge survival proportions and hazard ratios of different IPNV isolates used for selecting the challenge virus strain.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2016-02-19 14:40:24"}
  • {"files"=>["https://ndownloader.figshare.com/files/4228573"], "description"=>"<p>KM survival analysis for cohabitees challenged with different (12.5%, 20% and 30%) proportions of virus shedders of the total number of fish per tank (<i>N</i> = 90; Study III). All virus shedders were injected with 1x10<sup>7</sup> TCID<sub>50</sub>/fish with strain NVI015-TA. Mortality of shedders in the 10% and 30% proportion groups started on day 18 after challenge while for the 20% group day 21 after challenge was the first day of mortality. Overlaps in the KM survival curves for the cohabitees show that there was no statistical difference between the 10% and 20% (p>0.368), as well as between the 10% and 30% (p>0.1051) proportion of virus shedders of the total number of fish per tank.</p>", "links"=>[], "tags"=>["challenge models", "Atlantic salmon", "cohabitation challenge trials", "Infectious Pancreatic Necrosis Virus", "Salmo salar L", "T 217A motif", "cohabitation challenge model", "Cohabitation Challenge Model", "vaccine", "hazard risk ratio", "input variables", "NVI", "pancreatic necrosis virus", "efficacy", "TCID", "IPNV", "DC", "unvaccinated control fish", "control fish"], "article_id"=>2582674, "categories"=>["Neuroscience", "Biotechnology", "Environmental Sciences not elsewhere classified", "Ecology", "Biological Sciences not elsewhere classified", "Cancer", "Inorganic Chemistry", "Infectious Diseases"], "users"=>["Hetron Mweemba Munang’andu", "Nina Santi", "Børge Nilsen Fredriksen", "Knut-Egil Løkling", "Øystein Evensen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0148467.g002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Proportion_of_virus_shedders_/2582674", "title"=>"Proportion of virus shedders.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-02-19 14:40:24"}
  • {"files"=>["https://ndownloader.figshare.com/files/4228606"], "description"=>"<p>Comparison of post challenge survival proportions and infections of the high and low challenge dose of strain NVI015-TA.</p>", "links"=>[], "tags"=>["challenge models", "Atlantic salmon", "cohabitation challenge trials", "Infectious Pancreatic Necrosis Virus", "Salmo salar L", "T 217A motif", "cohabitation challenge model", "Cohabitation Challenge Model", "vaccine", "hazard risk ratio", "input variables", "NVI", "pancreatic necrosis virus", "efficacy", "TCID", "IPNV", "DC", "unvaccinated control fish", "control fish"], "article_id"=>2582707, "categories"=>["Neuroscience", "Biotechnology", "Environmental Sciences not elsewhere classified", "Ecology", "Biological Sciences not elsewhere classified", "Cancer", "Inorganic Chemistry", "Infectious Diseases"], "users"=>["Hetron Mweemba Munang’andu", "Nina Santi", "Børge Nilsen Fredriksen", "Knut-Egil Løkling", "Øystein Evensen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0148467.t002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Comparison_of_post_challenge_survival_proportions_and_infections_of_the_high_and_low_challenge_dose_of_strain_NVI015_TA_/2582707", "title"=>"Comparison of post challenge survival proportions and infections of the high and low challenge dose of strain NVI015-TA.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2016-02-19 14:40:24"}
  • {"files"=>["https://ndownloader.figshare.com/files/4228576"], "description"=>"<p>KM survival analysis for different strains of Atlantic salmon having different susceptibility to IPNV infection, challenged with strain NVI015-TA at 1x10<sup>7</sup>TCID<sub>50</sub>/fish. (A) KM survival analysis for the highly susceptible strain (HS<sub>strain</sub>). (B) KM survival analysis for the less susceptible strain (LS<sub>strain</sub>), both including vaccinated and unvaccinated control fish. Note that the discriminatory capacity (DC) between the vaccinated and control fish for the HS<sub>strain</sub> shown in Fig 3A (DC = 58.89%) was more than twice that of the LS<sub>strain</sub> shown in Fig 3B (DC = 24.22%).</p>", "links"=>[], "tags"=>["challenge models", "Atlantic salmon", "cohabitation challenge trials", "Infectious Pancreatic Necrosis Virus", "Salmo salar L", "T 217A motif", "cohabitation challenge model", "Cohabitation Challenge Model", "vaccine", "hazard risk ratio", "input variables", "NVI", "pancreatic necrosis virus", "efficacy", "TCID", "IPNV", "DC", "unvaccinated control fish", "control fish"], "article_id"=>2582677, "categories"=>["Neuroscience", "Biotechnology", "Environmental Sciences not elsewhere classified", "Ecology", "Biological Sciences not elsewhere classified", "Cancer", "Inorganic Chemistry", "Infectious Diseases"], "users"=>["Hetron Mweemba Munang’andu", "Nina Santi", "Børge Nilsen Fredriksen", "Knut-Egil Løkling", "Øystein Evensen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0148467.g003", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Effect_of_genetic_susceptibility_/2582677", "title"=>"Effect of genetic susceptibility.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-02-19 14:40:24"}
  • {"files"=>["https://ndownloader.figshare.com/files/4228609"], "description"=>"<p>Comparison of post challenge survival proportions and risk ratios of the high and low Atlantic salmon susceptible strains to NVI015-TA.</p>", "links"=>[], "tags"=>["challenge models", "Atlantic salmon", "cohabitation challenge trials", "Infectious Pancreatic Necrosis Virus", "Salmo salar L", "T 217A motif", "cohabitation challenge model", "Cohabitation Challenge Model", "vaccine", "hazard risk ratio", "input variables", "NVI", "pancreatic necrosis virus", "efficacy", "TCID", "IPNV", "DC", "unvaccinated control fish", "control fish"], "article_id"=>2582710, "categories"=>["Neuroscience", "Biotechnology", "Environmental Sciences not elsewhere classified", "Ecology", "Biological Sciences not elsewhere classified", "Cancer", "Inorganic Chemistry", "Infectious Diseases"], "users"=>["Hetron Mweemba Munang’andu", "Nina Santi", "Børge Nilsen Fredriksen", "Knut-Egil Løkling", "Øystein Evensen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0148467.t003", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Comparison_of_post_challenge_survival_proportions_and_risk_ratios_of_the_high_and_low_Atlantic_salmon_susceptible_strains_to_NVI015_TA_/2582710", "title"=>"Comparison of post challenge survival proportions and risk ratios of the high and low Atlantic salmon susceptible strains to NVI015-TA.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2016-02-19 14:40:24"}
  • {"files"=>["https://ndownloader.figshare.com/files/4228582"], "description"=>"<p>The production cycle of Atlantic salmon depicting the timing of IPN vaccination, challenge and convalescence. <b>A</b> indicates the immune induction period being the period between vaccination and challenge. Note that vaccination is carried out at the parr stage in freshwater before smoltification. <b>B</b> indicates the time of challenge at the post-smolt stage soon after transfer to seawater, which conforms to the time when most outbreaks occur during the Atlantic salmon production cycle. <b>C</b> shows the period after lethal challenge when the survivors become carriers or persistently infected with post challenge virus during convalescence.</p>", "links"=>[], "tags"=>["challenge models", "Atlantic salmon", "cohabitation challenge trials", "Infectious Pancreatic Necrosis Virus", "Salmo salar L", "T 217A motif", "cohabitation challenge model", "Cohabitation Challenge Model", "vaccine", "hazard risk ratio", "input variables", "NVI", "pancreatic necrosis virus", "efficacy", "TCID", "IPNV", "DC", "unvaccinated control fish", "control fish"], "article_id"=>2582683, "categories"=>["Neuroscience", "Biotechnology", "Environmental Sciences not elsewhere classified", "Ecology", "Biological Sciences not elsewhere classified", "Cancer", "Inorganic Chemistry", "Infectious Diseases"], "users"=>["Hetron Mweemba Munang’andu", "Nina Santi", "Børge Nilsen Fredriksen", "Knut-Egil Løkling", "Øystein Evensen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0148467.g004", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Salmon_production_cycle_/2582683", "title"=>"Salmon production cycle.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-02-19 14:40:24"}
  • {"files"=>["https://ndownloader.figshare.com/files/4228615"], "description"=>"<p>Comparison of three independent vaccine efficacy trials using the cohabitation challenge model in Atlantic salmon parr.</p>", "links"=>[], "tags"=>["challenge models", "Atlantic salmon", "cohabitation challenge trials", "Infectious Pancreatic Necrosis Virus", "Salmo salar L", "T 217A motif", "cohabitation challenge model", "Cohabitation Challenge Model", "vaccine", "hazard risk ratio", "input variables", "NVI", "pancreatic necrosis virus", "efficacy", "TCID", "IPNV", "DC", "unvaccinated control fish", "control fish"], "article_id"=>2582716, "categories"=>["Neuroscience", "Biotechnology", "Environmental Sciences not elsewhere classified", "Ecology", "Biological Sciences not elsewhere classified", "Cancer", "Inorganic Chemistry", "Infectious Diseases"], "users"=>["Hetron Mweemba Munang’andu", "Nina Santi", "Børge Nilsen Fredriksen", "Knut-Egil Løkling", "Øystein Evensen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0148467.t004", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Comparison_of_three_independent_vaccine_efficacy_trials_using_the_cohabitation_challenge_model_in_Atlantic_salmon_parr_/2582716", "title"=>"Comparison of three independent vaccine efficacy trials using the cohabitation challenge model in Atlantic salmon parr.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2016-02-19 14:40:24"}

PMC Usage Stats | Further Information

  • {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"16", "full-text"=>"14", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"17", "full-text"=>"15", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"14", "full-text"=>"13", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"16", "full-text"=>"14", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"9", "full-text"=>"5", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"11", "full-text"=>"9", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"13", "full-text"=>"15", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"13", "full-text"=>"15", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"10", "full-text"=>"11", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"10", "full-text"=>"11", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"10", "full-text"=>"8", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"19", "full-text"=>"19", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"14", "full-text"=>"15", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"12", "full-text"=>"14", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"6", "full-text"=>"4", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"12", "full-text"=>"13", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"14", "full-text"=>"15", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"12", "full-text"=>"16", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"18", "full-text"=>"19", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"13", "full-text"=>"11", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"9", "full-text"=>"10", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}
  • {"unique-ip"=>"15", "full-text"=>"19", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"2"}
  • {"unique-ip"=>"10", "full-text"=>"11", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"3"}
  • {"unique-ip"=>"5", "full-text"=>"7", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"4"}
  • {"unique-ip"=>"14", "full-text"=>"11", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"5"}
  • {"unique-ip"=>"17", "full-text"=>"14", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"6"}

Relative Metric

{"start_date"=>"2016-01-01T00:00:00Z", "end_date"=>"2016-12-31T00:00:00Z", "subject_areas"=>[]}
Loading … Spinner
There are currently no alerts