Electroacupuncture Produces the Sustained Motor Improvement in 6-Hydroxydopamine-Lesioned Mice
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{"title"=>"Electroacupuncture produces the sustained motor improvement in 6-hydroxydopamine-lesioned mice", "type"=>"journal", "authors"=>[{"first_name"=>"Yan", "last_name"=>"Yu", "scopus_author_id"=>"57171094400"}, {"first_name"=>"Ke", "last_name"=>"Wang", "scopus_author_id"=>"57171146200"}, {"first_name"=>"Jiahui", "last_name"=>"Deng", "scopus_author_id"=>"54990357200"}, {"first_name"=>"Min", "last_name"=>"Sun", "scopus_author_id"=>"57171268400"}, {"first_name"=>"Jun", "last_name"=>"Jia", "scopus_author_id"=>"57195372478"}, {"first_name"=>"Xiaomin", "last_name"=>"Wang", "scopus_author_id"=>"10340317100"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "pui"=>"608920446", "doi"=>"10.1371/journal.pone.0149111", "sgr"=>"84960970187", "pmid"=>"26894437", "scopus"=>"2-s2.0-84960970187"}, "id"=>"265ec7c8-0303-3a09-8ad1-e48db3126bbc", "abstract"=>"Clinical and research evidence has shown that electroacupuncture (EA) promotes recovery of motor function in patients with Parkinson’s disease (PD). However, the “efficacy span” of EA treatment, especially the long-term effect of EA that is thought to last after the cessation of EA treatment, has not been investigated. The present study thus investigated and compared the effect of EA during and after chronic EA application on motor activity and dopamine lesions in a 6-hydroxydopamine (6-OHDA)-lesioned mouse model of PD. Chronic EA treatment (30 min a day, 6 days a week for 2 or 4 weeks) significantly attenuated motor deficiency and reduced dopamine neuron degeneration. Remarkably, EA showed a long-lasting effect after the cessation of EA stimulation. At 2 and 4 weeks after the termination of EA, EA continued to improve motor function in 6-OHDA-lesioned mice. Consistent with sustained behavioral effects, EA induced an enduring increase in the dopamine turnover ratio in the striatum 2 weeks after the cessation of EA treatment. Here we demonstrated that the therapeutic effect of EA outlasted the duration of EA application. During a relatively long period of time after the completion of EA treatment, EA is able to continue to improve motor function and enhance dopamine availability in 6-OHDA-lesioned PD mice. [ABSTRACT FROM AUTHOR]", "link"=>"http://www.mendeley.com/research/electroacupuncture-produces-sustained-motor-improvement-6hydroxydopaminelesioned-mice", "reader_count"=>9, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Researcher"=>2, "Student > Ph. D. Student"=>1, "Other"=>1, "Student > Bachelor"=>1, "Professor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Researcher"=>2, "Student > Ph. D. Student"=>1, "Other"=>1, "Student > Bachelor"=>1, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Biochemistry, Genetics and Molecular Biology"=>1, "Neuroscience"=>3, "Psychology"=>1, "Economics, Econometrics and Finance"=>1, "Medicine and Dentistry"=>1}, "reader_count_by_subdiscipline"=>{"Neuroscience"=>{"Neuroscience"=>3}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Psychology"=>{"Psychology"=>1}, "Economics, Econometrics and Finance"=>{"Economics, Econometrics and Finance"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>2}}, "group_count"=>0}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/4215679"], "description"=>"<p>After 2 weeks post-lesion by 6-OHDA, the mice were subjected to the EA stimulation (30 min a day, 6 days a week for a total of 4 weeks). Behavioral test, immunohistochemistrical staining for tyrosine hydroxylase (TH), content of DA and its metabolites were performed at the end of 2<sup>nd</sup>, 4<sup>th</sup>, 6<sup>th</sup> and 8<sup>th</sup> week.</p>", "links"=>[], "tags"=>["EA application", "dopamine turnover ratio", "Sustained Motor Improvement", "motor function", "4 weeks", "PD", "attenuated motor deficiency", "striatum 2 weeks", "OHDA", "dopamine neuron degeneration", "EA treatment"], "article_id"=>2572480, "categories"=>["Neuroscience", "Cancer", "Mental Health"], "users"=>["Yan Yu", "Ke Wang", "Jiahui Deng", "Min Sun", "Jun Jia", "Xiaomin Wang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0149111.g001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Graphical_representation_of_the_experimental_design_/2572480", "title"=>"Graphical representation of the experimental design.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-02-19 11:27:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/4215685"], "description"=>"<p>(A) Rotarod test. The time to fall off the rotarod treadmill was recorded as the latency. (B) Cylinder test. The percentage of contralateral paw contacts relative to the lesioned hemisphere was calculated by contralateral touches / (contralateral touches + ipsilateral touches + simultaneous touches). Locomotor activity was assessed by horizontal (C) and vertical (D) movement distance. (E) Immunohistochemistrical staining for TH positive dopaminergic neurons in the SNpc (scale bar: 100 μm) and fibers in the striatum (scale bar: 50 μm). (F) The percentage of TH positive dopaminergic neurons from the SNpc in the lesioned side relative to that in the unlesioned side. (G) Optical density was used to evaluate relative TH expression from lesioned striatum compared with unlesioned one. The values were expressed as means ± SEM. n = 10–12 per group for the behavior tests; n = 5 per group for the immunohistochemical experiments. * <i>P</i> <0.05; ** <i>P</i> <0.01; *** <i>P</i> <0.001 <i>vs</i>. Sham group. # <i>P</i> <0.05; ## <i>P</i> <0.01 <i>vs</i>. 0 Hz group.</p>", "links"=>[], "tags"=>["EA application", "dopamine turnover ratio", "Sustained Motor Improvement", "motor function", "4 weeks", "PD", "attenuated motor deficiency", "striatum 2 weeks", "OHDA", "dopamine neuron degeneration", "EA treatment"], "article_id"=>2572489, "categories"=>["Neuroscience", "Cancer", "Mental Health"], "users"=>["Yan Yu", "Ke Wang", "Jiahui Deng", "Min Sun", "Jun Jia", "Xiaomin Wang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0149111.g002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Two_weeks_EA_stimulation_exerted_the_behavioral_improvements_and_neuroprotective_effects_on_6_OHDA_lesioned_mice_/2572489", "title"=>"Two weeks’ EA stimulation exerted the behavioral improvements and neuroprotective effects on 6-OHDA-lesioned mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-02-19 11:27:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/4215700"], "description"=>"<p>(A) Rotarod test. (B) Cylinder test. (C) Horizontal locomotor distance. (D) Vertical locomotor distance. (F) Immunohistochemistrical staining for TH positive dopaminergic neurons in the SNpc (scale bar: 100 μm) and fibers in the striatum (scale bar: 50 μm). (G) The percentage of TH positive dopaminergic neurons in the SNpc (H) The percentage of average optical density of TH positive dopaminergic fibers in the striatum. The data were expressed as means ± S.E.M. n = 10–12 per group for the behavior tests; n = 5 per group for the immunohistochemistrical experiments. The values were expressed as means ± SEM. * <i>P</i> <0.05; ** <i>P</i> < 0.01; *** <i>P</i> <0.001 <i>vs</i>. Sham group. # <i>P</i> <0.05; ### <i>P</i> <0.001 <i>vs</i>. 0 Hz group.</p>", "links"=>[], "tags"=>["EA application", "dopamine turnover ratio", "Sustained Motor Improvement", "motor function", "4 weeks", "PD", "attenuated motor deficiency", "striatum 2 weeks", "OHDA", "dopamine neuron degeneration", "EA treatment"], "article_id"=>2572501, "categories"=>["Neuroscience", "Cancer", "Mental Health"], "users"=>["Yan Yu", "Ke Wang", "Jiahui Deng", "Min Sun", "Jun Jia", "Xiaomin Wang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0149111.g003", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Four_weeks_EA_stimulation_exerted_the_behavioral_improvement_and_neuroprotective_effects_on_6_OHDA_lesioned_mice_/2572501", "title"=>"Four weeks’ EA stimulation exerted the behavioral improvement and neuroprotective effects on 6-OHDA-lesioned mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-02-19 11:27:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/4215709"], "description"=>"<p>Time-dependent alteration of the behavioral performance in each group, such as rotarod test (A), cylinder test (B), horizontal locomotor distance (C) and vertical locomotor distance (D). (E) immunohistochemistrical staining for TH positive dopaminergic neurons in the SNpc (scale bar: 100 μm) and fibers in the striatum (scale bar: 50 μm) were showed at 2<sup>nd</sup> and 4<sup>th</sup> week after the termination of EA stimulation (which be described as EA 4 Weeks / 2 Weeks and EA 4 Weeks / 4 Weeks, respectively). Bar graph of the percentage of TH positive dopaminergic neurons in the SNpc (F) and the fibers in the striatum (G) at the end of 2<sup>nd</sup> week after the termination of EA stimulation. At the 4<sup>th</sup> week after the termination of EA stimulation, the percentage of TH positive dopaminergic neurons in the SNpc was shown as the bar graph (H), and the fibers in the striatum was shown as the bar graph (I). n = 10–12 per group for the behavior tests; n = 5 per group for the immunohistochemistrical experiments. The values were expressed as means ± SEM. * <i>P</i> <0.05; ** <i>P</i> <0.01; *** <i>P</i> <0.001 <i>vs</i>. Sham. # <i>P</i> <0.05; ## <i>P</i> <0.01 <i>vs</i>. 0 Hz group.</p>", "links"=>[], "tags"=>["EA application", "dopamine turnover ratio", "Sustained Motor Improvement", "motor function", "4 weeks", "PD", "attenuated motor deficiency", "striatum 2 weeks", "OHDA", "dopamine neuron degeneration", "EA treatment"], "article_id"=>2572510, "categories"=>["Neuroscience", "Cancer", "Mental Health"], "users"=>["Yan Yu", "Ke Wang", "Jiahui Deng", "Min Sun", "Jun Jia", "Xiaomin Wang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0149111.g004", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/EA_produces_a_long_last_neuroprotection_in_6_OHDA_lesioned_mice_after_the_termination_of_EA_stimulation_/2572510", "title"=>"EA produces a long-last neuroprotection in 6-OHDA-lesioned mice after the termination of EA stimulation.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-02-19 11:27:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/4215718"], "description"=>"<p>Contents of DA(A), DOPAC(B), HVA(C), and turnover ratios of DOPAC/DA (D), HVA/DA (E), (DOPAC plus HVA)/DA (F) in the striatum were analyzed at the end of 2<sup>nd</sup> week after the termination EA treatment (EA 4 Weeks / 2 Weeks). DA (G), DOPAC (H), HVA (I), DOPAC/DA (J), HVA/DA (K), (DOPAC plus HVA)/DA (L) were analyzed at the end of 4<sup>th</sup> week after the termination of four-week EA stimulation (EA 4 Weeks / 4 Weeks). The values were expressed as means ± SEM. n = 7 per group. * <i>P</i> <0.05; ** <i>P</i> <0.01; *** <i>P</i> <0.001 <i>vs</i>. Sham group. # <i>P</i> < 0.05; ## <i>P</i> <0.01 <i>vs</i>. 6-OHDA group.</p>", "links"=>[], "tags"=>["EA application", "dopamine turnover ratio", "Sustained Motor Improvement", "motor function", "4 weeks", "PD", "attenuated motor deficiency", "striatum 2 weeks", "OHDA", "dopamine neuron degeneration", "EA treatment"], "article_id"=>2572519, "categories"=>["Neuroscience", "Cancer", "Mental Health"], "users"=>["Yan Yu", "Ke Wang", "Jiahui Deng", "Min Sun", "Jun Jia", "Xiaomin Wang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0149111.g005", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Dopamine_and_its_metabolites_in_the_striatum_at_the_2_sup_nd_sup_and_4_sup_th_sup_week_after_the_termination_of_EA_stimulation_in_6_OHDA_lesioned_mice_/2572519", "title"=>"Dopamine and its metabolites in the striatum at the 2<sup>nd</sup> and 4<sup>th</sup> week after the termination of EA stimulation in 6-OHDA-lesioned mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-02-19 11:27:11"}

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Relative Metric

{"start_date"=>"2016-01-01T00:00:00Z", "end_date"=>"2016-12-31T00:00:00Z", "subject_areas"=>[]}
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