Thrombin Generation in Zebrafish Blood
Publication Date
February 12, 2016
Journal
PLOS ONE
Authors
Evelien Schurgers, Martijn Moorlag, Coenraad Hemker, Theo Lindhout, et al
Volume
11
Issue
2
Pages
e0149135
DOI
https://dx.plos.org/10.1371/journal.pone.0149135
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0149135
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/26872266
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752272
Europe PMC
http://europepmc.org/abstract/MED/26872266
Scopus
84960533498
Mendeley
http://www.mendeley.com/research/thrombin-generation-zebrafish-blood
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Mendeley | Further Information

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Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/3931213"], "description"=>"<p>Representative image of SEM analysis of blood clots formed during thrombin generation measurements. Sequential enlargements of the fibrin network with entrapped red blood cells are depicted. <b>(A)</b> Zebrafish blood clot. <b>(B)</b> Human blood clot without added tissue factor (TF). <b>(C)</b> Human blood clot with addition of a high dose (100 pM) of TF.</p>", "links"=>[], "tags"=>["thrombin generation", "blood thrombin generation", "zebrafish", "scanning electron microscopy", "measure thrombin generation", "hemostasi", "thrombosis", "model"], "article_id"=>2294128, "categories"=>["Biochemistry", "Medicine", "Microbiology", "Cell Biology", "Genetics", "Molecular Biology", "Physiology", "Pharmacology", "Immunology", "Biological Sciences not elsewhere classified", "Information Systems not elsewhere classified", "Developmental Biology", "Science Policy", "Hematology", "Infectious Diseases"], "users"=>["Evelien Schurgers", "Martijn Moorlag", "Coenraad Hemker", "Theo Lindhout", "Hilde Kelchtermans", "Bas de Laat"], "doi"=>"https://dx.doi.org/2294128", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Scanning_electron_microscopy_SEM_of_blood_clots_/2294128", "title"=>"Scanning electron microscopy (SEM) of blood clots.", "pos_in_sequence"=>4, "defined_type"=>1, "published_date"=>"2016-02-12 13:31:09"}
  • {"files"=>["https://ndownloader.figshare.com/files/3931144"], "description"=>"<p>Zebrafish were treated with 30 μg/g aspirin or vehicle for 30 min <b>(A-B)</b> or were allowed to swim in aspirin-supplemented water (250 mg/ml) for 24 hours <b>(C-D)</b>, followed by thrombin generation measurements. <b>(A,C)</b> Thrombin generation curves are shown. <b>(B,D)</b> Results are expressed as the percentage inhibition compared to a control group of vehicle-treated fish (n = 5). The percentage CV is indicated for all parameters. *Mann-Whitney U-test as compared to controls.</p>", "links"=>[], "tags"=>["thrombin generation", "blood thrombin generation", "zebrafish", "scanning electron microscopy", "measure thrombin generation", "hemostasi", "thrombosis", "model"], "article_id"=>2294089, "categories"=>["Biochemistry", "Medicine", "Microbiology", "Cell Biology", "Genetics", "Molecular Biology", "Physiology", "Pharmacology", "Immunology", "Biological Sciences not elsewhere classified", "Information Systems not elsewhere classified", "Developmental Biology", "Science Policy", "Hematology", "Infectious Diseases"], "users"=>["Evelien Schurgers", "Martijn Moorlag", "Coenraad Hemker", "Theo Lindhout", "Hilde Kelchtermans", "Bas de Laat"], "doi"=>"https://dx.doi.org/2294089", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Inhibition_of_thrombin_generation_in_zebrafish_by_inhibition_of_platelet_aggregation_/2294089", "title"=>"Inhibition of thrombin generation in zebrafish by inhibition of platelet aggregation.", "pos_in_sequence"=>3, "defined_type"=>1, "published_date"=>"2016-02-12 13:31:09"}
  • {"files"=>["https://ndownloader.figshare.com/files/3930994"], "description"=>"<p>Thrombin generation was measured in zebrafish at 28°C and 37°C and compared to thrombin generation in humans at 37°C with low (no tissue factor (TF) added) or high (100 pM) TF. <b>(A)</b> Thrombin generation curves are shown (n = 8 or 9 for fish, n = 3 for humans). <b>(B)</b> Mean thrombin generation parameters and their CV are calculated. Statistical differences as compared to the zebrafish group measured at 37°C are indicated (*p<0.05, **p<0.01, ***p<0.0001, 1-way ANOVA). <b>(C-D)</b> Thrombin generation was measured in 6 independent experiments, in a total of 34 zebrafish. <b>(C)</b> Thrombin generation curves are shown. Each color represents an independent experiment. <b>(D)</b> Mean thrombin generation parameters and their CV are calculated, as well as the CV between the means of all 6 experiments (interexp. CV).</p>", "links"=>[], "tags"=>["thrombin generation", "blood thrombin generation", "zebrafish", "scanning electron microscopy", "measure thrombin generation", "hemostasi", "thrombosis", "model"], "article_id"=>2293978, "categories"=>["Biochemistry", "Medicine", "Microbiology", "Cell Biology", "Genetics", "Molecular Biology", "Physiology", "Pharmacology", "Immunology", "Biological Sciences not elsewhere classified", "Information Systems not elsewhere classified", "Developmental Biology", "Science Policy", "Hematology", "Infectious Diseases"], "users"=>["Evelien Schurgers", "Martijn Moorlag", "Coenraad Hemker", "Theo Lindhout", "Hilde Kelchtermans", "Bas de Laat"], "doi"=>"https://dx.doi.org/2293978", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Thrombin_generation_curves_and_parameters_in_zebrafish_effect_of_temperature_and_comparison_with_humans_/2293978", "title"=>"Thrombin generation curves and parameters in zebrafish, effect of temperature and comparison with humans.", "pos_in_sequence"=>1, "defined_type"=>1, "published_date"=>"2016-02-12 13:31:09"}
  • {"files"=>["https://ndownloader.figshare.com/files/3931066"], "description"=>"<p>Zebrafish were treated with melagatran <b>(A)</b> or rivaroxaban <b>(B)</b> at the indicated doses for 30 min, followed by thrombin generation measurements. <b>(C-D)</b> Results of two independent experiments are expressed as the percentage inhibition compared to a control group of vehicle-treated fish (n = 8). The percentage CV is indicated for all parameters. Statistical differences between treatment and control groups were performed with *Mann-Whitney U-test or <sup>$</sup>1-way ANOVA. (ns = not significant).</p>", "links"=>[], "tags"=>["thrombin generation", "blood thrombin generation", "zebrafish", "scanning electron microscopy", "measure thrombin generation", "hemostasi", "thrombosis", "model"], "article_id"=>2294035, "categories"=>["Biochemistry", "Medicine", "Microbiology", "Cell Biology", "Genetics", "Molecular Biology", "Physiology", "Pharmacology", "Immunology", "Biological Sciences not elsewhere classified", "Information Systems not elsewhere classified", "Developmental Biology", "Science Policy", "Hematology", "Infectious Diseases"], "users"=>["Evelien Schurgers", "Martijn Moorlag", "Coenraad Hemker", "Theo Lindhout", "Hilde Kelchtermans", "Bas de Laat"], "doi"=>"https://dx.doi.org/2294035", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Inhibition_of_thrombin_generation_in_zebrafish_by_thrombin_or_FXa_inhibition_/2294035", "title"=>"Inhibition of thrombin generation in zebrafish by thrombin or FXa inhibition.", "pos_in_sequence"=>2, "defined_type"=>1, "published_date"=>"2016-02-12 13:31:09"}

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  • {"unique-ip"=>"19", "full-text"=>"20", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"12", "full-text"=>"10", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"13", "full-text"=>"13", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"12", "full-text"=>"13", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"15", "full-text"=>"12", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"12", "full-text"=>"19", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"3", "full-text"=>"1", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"4", "full-text"=>"5", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"5", "full-text"=>"7", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"13", "full-text"=>"12", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"12", "full-text"=>"15", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"17", "full-text"=>"17", "pdf"=>"15", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}

Relative Metric

{"start_date"=>"2016-01-01T00:00:00Z", "end_date"=>"2016-12-31T00:00:00Z", "subject_areas"=>[]}
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