Elevated Toll-Like Receptor-Induced CXCL8 Secretion in Human Blood Basophils from Allergic Donors Is Independent of Toll-Like Receptor Expression Levels
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{"title"=>"Elevated Toll-like receptor-induced CXCL8 secretion in human blood basophils from allergic donors is independent of Toll-like receptor expression levels", "type"=>"journal", "authors"=>[{"first_name"=>"Markus", "last_name"=>"Steiner", "scopus_author_id"=>"53064487900"}, {"first_name"=>"Thomas", "last_name"=>"Hawranek", "scopus_author_id"=>"6603181829"}, {"first_name"=>"Michael", "last_name"=>"Schneider", "scopus_author_id"=>"23028939400"}, {"first_name"=>"Fatima", "last_name"=>"Ferreira", "scopus_author_id"=>"7103359074"}, {"first_name"=>"Jutta", "last_name"=>"Horejs-Hoeck", "scopus_author_id"=>"6506721521"}, {"first_name"=>"Andrea", "last_name"=>"Harrer", "scopus_author_id"=>"26534231600"}, {"first_name"=>"Martin", "last_name"=>"Himly", "scopus_author_id"=>"6602909744"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"26870962", "doi"=>"10.1371/journal.pone.0149275", "pui"=>"608920773", "issn"=>"19326203", "sgr"=>"84960516964", "scopus"=>"2-s2.0-84960516964"}, "id"=>"cdc5dfae-2b09-3806-9918-ff663dd2a5f1", "abstract"=>"Human blood basophils have recently gained interest in addition to their function as allergic effector cells. Previous work suggests the involvement of innate immune mechanisms in the development and exacerbation of allergic responses, which might be mediated by basophils. We assayed the expression levels of Toll-like receptor (TLR) 1, 2, 4 and 6 on purified basophils from birch pollen-, house dust mite-, and non-allergic individuals. Additionally, we compared cytokine and chemokine secretion upon TLR stimulation in these basophil donor groups. Expression of TLR4 on the basophils of the allergic donor groups was decreased and CXCL8 secretion was elevated upon stimulation of TLR1/2 and TLR2/6 compared to the non-allergic donors. Decreased TLR expression and elevated CXCL8 secretion may represent possible mechanisms for aggravation of allergic symptoms in case of parasitic infection.", "link"=>"http://www.mendeley.com/research/elevated-tolllike-receptorinduced-cxcl8-secretion-human-blood-basophils-allergic-donors-independent", "reader_count"=>8, "reader_count_by_academic_status"=>{"Researcher"=>3, "Student > Ph. D. Student"=>2, "Student > Bachelor"=>1, "Professor"=>1, "Unspecified"=>1}, "reader_count_by_user_role"=>{"Researcher"=>3, "Student > Ph. D. Student"=>2, "Student > Bachelor"=>1, "Professor"=>1, "Unspecified"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>1, "Medicine and Dentistry"=>2, "Agricultural and Biological Sciences"=>2, "Immunology and Microbiology"=>2, "Unspecified"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>1}}, "group_count"=>0}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/3930127"], "description"=>"<p>Shown are one representative non-allergic donor (a) and one house dust mite (HDM)-allergic patient (b).</p>", "links"=>[], "tags"=>["basophil donor groups", "donor groups", "Allergic Donors", "chemokine secretion", "Previous work", "TLR stimulation", "Human Blood Basophils", "expression levels", "effector cells", "CXCL 8 secretion", "TLR 4", "Decreased TLR expression"], "article_id"=>2293288, "categories"=>["Biochemistry", "Medicine", "Genetics", "Molecular Biology", "Physiology", "Chemical Sciences not elsewhere classified", "Immunology", "Biological Sciences not elsewhere classified", "Developmental Biology", "Marine Biology", "Infectious Diseases"], "users"=>["Markus Steiner", "Thomas Hawranek", "Michael Schneider", "Fatima Ferreira", "Jutta Horejs-Hoeck", "Andrea Harrer", "Martin Himly"], "doi"=>"https://dx.doi.org/2293288", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Gating_strategy_/2293288", "title"=>"Gating strategy.", "pos_in_sequence"=>2, "defined_type"=>1, "published_date"=>"2016-02-12 13:25:25"}
  • {"files"=>["https://ndownloader.figshare.com/files/3930091"], "description"=>"<p>(<b>a</b>), Forward/side scatter plot of purified basophil fraction. (<b>b</b>), CCR3 expression of the recorded events. (<b>c</b>), a representative non-stimulated cell sample showing a putative basophil population. (<b>d</b>), upon stimulation with anti-FcεRI the CCR3 positive/CD203c shifting population was gated for purity determination. In this representative sample basophil purity was 95%.</p>", "links"=>[], "tags"=>["basophil donor groups", "donor groups", "Allergic Donors", "chemokine secretion", "Previous work", "TLR stimulation", "Human Blood Basophils", "expression levels", "effector cells", "CXCL 8 secretion", "TLR 4", "Decreased TLR expression"], "article_id"=>2293252, "categories"=>["Biochemistry", "Medicine", "Genetics", "Molecular Biology", "Physiology", "Chemical Sciences not elsewhere classified", "Immunology", "Biological Sciences not elsewhere classified", "Developmental Biology", "Marine Biology", "Infectious Diseases"], "users"=>["Markus Steiner", "Thomas Hawranek", "Michael Schneider", "Fatima Ferreira", "Jutta Horejs-Hoeck", "Andrea Harrer", "Martin Himly"], "doi"=>"https://dx.doi.org/2293252", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Determination_of_basophil_purity_/2293252", "title"=>"Determination of basophil purity.", "pos_in_sequence"=>1, "defined_type"=>1, "published_date"=>"2016-02-12 13:25:25"}
  • {"files"=>["https://ndownloader.figshare.com/files/3930262"], "description"=>"<p>Allergic patients and non-allergic donors.</p>", "links"=>[], "tags"=>["basophil donor groups", "donor groups", "Allergic Donors", "chemokine secretion", "Previous work", "TLR stimulation", "Human Blood Basophils", "expression levels", "effector cells", "CXCL 8 secretion", "TLR 4", "Decreased TLR expression"], "article_id"=>2293402, "categories"=>["Biochemistry", "Medicine", "Genetics", "Molecular Biology", "Physiology", "Chemical Sciences not elsewhere classified", "Immunology", "Biological Sciences not elsewhere classified", "Developmental Biology", "Marine Biology", "Infectious Diseases"], "users"=>["Markus Steiner", "Thomas Hawranek", "Michael Schneider", "Fatima Ferreira", "Jutta Horejs-Hoeck", "Andrea Harrer", "Martin Himly"], "doi"=>"https://dx.doi.org/2293402", "stats"=>{"downloads"=>2, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Allergic_patients_and_non_allergic_donors_/2293402", "title"=>"Allergic patients and non-allergic donors.", "pos_in_sequence"=>5, "defined_type"=>3, "published_date"=>"2016-02-12 13:25:25"}
  • {"files"=>["https://ndownloader.figshare.com/files/3930184"], "description"=>"<p>Expression levels of significantly detectable TLR1, 2, and 4 were investigated between non-allergic (NA), birch pollen (BP)-allergic and house dust mite (HDM)-allergic donors (n = 8, each): (<b>a</b>), group-wise (n = 24 each) comparisons of TLR expressions (antibody staining, AS) with the respective isotype controls (IC); (<b>b</b>), comparison of TLR1, 2, 4 expression between non-allergic (NA) donors and HDM-/PB-allergic patients (n = 8, each). Group comparisons were performed by Wilcoxon matched pairs test in (a) and Kruskal-Wallis test with Dunn’s <i>post hoc</i> test in (b). Bars represent medians. NS, non-stimulated; *, p<0.05.</p>", "links"=>[], "tags"=>["basophil donor groups", "donor groups", "Allergic Donors", "chemokine secretion", "Previous work", "TLR stimulation", "Human Blood Basophils", "expression levels", "effector cells", "CXCL 8 secretion", "TLR 4", "Decreased TLR expression"], "article_id"=>2293339, "categories"=>["Biochemistry", "Medicine", "Genetics", "Molecular Biology", "Physiology", "Chemical Sciences not elsewhere classified", "Immunology", "Biological Sciences not elsewhere classified", "Developmental Biology", "Marine Biology", "Infectious Diseases"], "users"=>["Markus Steiner", "Thomas Hawranek", "Michael Schneider", "Fatima Ferreira", "Jutta Horejs-Hoeck", "Andrea Harrer", "Martin Himly"], "doi"=>"https://dx.doi.org/2293339", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Overview_of_TLR_expression_on_purified_human_basophils_/2293339", "title"=>"Overview of TLR expression on purified human basophils.", "pos_in_sequence"=>3, "defined_type"=>1, "published_date"=>"2016-02-12 13:25:25"}
  • {"files"=>["https://ndownloader.figshare.com/files/3930232"], "description"=>"<p>Stimulation of TLR1/2 with Pam<sub>3</sub>CSK<sub>4</sub> (<b>a</b>), of TLR2/6 with Pam<sub>2</sub>CSK<sub>4</sub> (<b>b</b>) and of TLR4 with LPS (<b>c</b>). (<b>d</b>), CD203c expression of all donors (n = 21); upon stimulation with positive controls (anti-FcεRI, fMLF) and the three TLR ligands (Pam<sub>3</sub>CSK<sub>4</sub>, Pam<sub>2</sub>CSK<sub>4</sub>, and LPS). Group comparisons were performed by two-way repeated measures ANOVA (a, b, c) with Bonferroni’s <i>post hoc</i> test and Kruskal-Wallis test with Dunn’s <i>post hoc</i> test (d). Bars represent medians. NS, non-stimulated; *, p<0.05.</p>", "links"=>[], "tags"=>["basophil donor groups", "donor groups", "Allergic Donors", "chemokine secretion", "Previous work", "TLR stimulation", "Human Blood Basophils", "expression levels", "effector cells", "CXCL 8 secretion", "TLR 4", "Decreased TLR expression"], "article_id"=>2293387, "categories"=>["Biochemistry", "Medicine", "Genetics", "Molecular Biology", "Physiology", "Chemical Sciences not elsewhere classified", "Immunology", "Biological Sciences not elsewhere classified", "Developmental Biology", "Marine Biology", "Infectious Diseases"], "users"=>["Markus Steiner", "Thomas Hawranek", "Michael Schneider", "Fatima Ferreira", "Jutta Horejs-Hoeck", "Andrea Harrer", "Martin Himly"], "doi"=>"https://dx.doi.org/2293387", "stats"=>{"downloads"=>2, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/CXCL8_secretion_and_CD203c_expression_of_purified_human_basophils_of_non_allergic_NA_birch_pollen_BP_allergic_and_house_dust_mite_HDM_allergic_donors_n_7_each_/2293387", "title"=>"CXCL8 secretion and CD203c expression of purified human basophils of non-allergic (NA), birch pollen (BP)-allergic, and house dust mite (HDM)-allergic donors (n = 7, each).", "pos_in_sequence"=>4, "defined_type"=>1, "published_date"=>"2016-02-12 13:25:25"}

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  • {"unique-ip"=>"8", "full-text"=>"12", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"6", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"4", "full-text"=>"2", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"8", "full-text"=>"5", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}

Relative Metric

{"start_date"=>"2016-01-01T00:00:00Z", "end_date"=>"2016-12-31T00:00:00Z", "subject_areas"=>[]}
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