Coenzyme Q10 Levels Are Decreased in the Cerebellum of Multiple-System Atrophy Patients
Publication Date
February 19, 2016
Journal
PLOS ONE
Authors
Lucia V. Schottlaender, Conceição Bettencourt, Aoife P. Kiely, Annapurna Chalasani, et al
Volume
11
Issue
2
Pages
e0149557
DOI
https://dx.plos.org/10.1371/journal.pone.0149557
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0149557
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/26894433
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760984
Europe PMC
http://europepmc.org/abstract/MED/26894433
Web of Science
000371223400065
Scopus
84960886096
Mendeley
http://www.mendeley.com/research/coenzyme-q10-levels-decreased-cerebellum-multiplesystem-atrophy-patients
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Mendeley | Further Information

{"title"=>"Coenzyme Q10 levels are decreased in the cerebellum of multiple-system atrophy patients", "type"=>"journal", "authors"=>[{"first_name"=>"Lucia V.", "last_name"=>"Schottlaender", "scopus_author_id"=>"36911788600"}, {"first_name"=>"Conceição", "last_name"=>"Bettencourt", "scopus_author_id"=>"8581587200"}, {"first_name"=>"Aoife P.", "last_name"=>"Kiely", "scopus_author_id"=>"56492689200"}, {"first_name"=>"Annapurna", "last_name"=>"Chalasani", "scopus_author_id"=>"55279544700"}, {"first_name"=>"Viruna", "last_name"=>"Neergheen", "scopus_author_id"=>"36155760400"}, {"first_name"=>"Janice L.", "last_name"=>"Holton", "scopus_author_id"=>"7101772051"}, {"first_name"=>"Iain", "last_name"=>"Hargreaves", "scopus_author_id"=>"7003781174"}, {"first_name"=>"Henry", "last_name"=>"Houlden", "scopus_author_id"=>"7003363686"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"608920713", "pmid"=>"26894433", "doi"=>"10.1371/journal.pone.0149557", "issn"=>"19326203", "scopus"=>"2-s2.0-84960886096", "sgr"=>"84960886096"}, "id"=>"fbc9ff26-d1b6-3da8-922d-5be977a3fafb", "abstract"=>"BACKGROUND The objective of this study was to evaluate whether the levels of coenzyme Q10 (CoQ10) in brain tissue of multiple system atrophy (MSA) patients differ from those in elderly controls and in patients with other neurodegenerative diseases. METHODS Flash frozen brain tissue of a series of 20 pathologically confirmed MSA patients [9 olivopontocerebellar atrophy (OPCA) type, 6 striatonigral degeneration (SND) type, and 5 mixed type] was used for this study. Elderly controls (n = 37) as well as idiopathic Parkinson's disease (n = 7), dementia with Lewy bodies (n = 20), corticobasal degeneration (n = 15) and cerebellar ataxia (n = 18) patients were used as comparison groups. CoQ10 was measured in cerebellar and frontal cortex tissue by high performance liquid chromatography. RESULTS We detected a statistically significant decrease (by 3-5%) in the level of CoQ10 in the cerebellum of MSA cases (P = 0.001), specifically in OPCA (P = 0.001) and mixed cases (P = 0.005), when compared to controls as well as to other neurodegenerative diseases [dementia with Lewy bodies (P<0.001), idiopathic Parkinson's disease (P<0.001), corticobasal degeneration (P<0.001), and cerebellar ataxia (P = 0.001)]. CONCLUSION Our results suggest that a perturbation in the CoQ10 biosynthetic pathway is associated with the pathogenesis of MSA but the mechanism behind this finding remains to be elucidated.", "link"=>"http://www.mendeley.com/research/coenzyme-q10-levels-decreased-cerebellum-multiplesystem-atrophy-patients", "reader_count"=>9, "reader_count_by_academic_status"=>{"Researcher"=>1, "Student > Ph. D. Student"=>3, "Other"=>1, "Student > Bachelor"=>1, "Lecturer"=>2, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_user_role"=>{"Researcher"=>1, "Student > Ph. D. Student"=>3, "Other"=>1, "Student > Bachelor"=>1, "Lecturer"=>2, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_subject_area"=>{"Medicine and Dentistry"=>7, "Agricultural and Biological Sciences"=>1, "Neuroscience"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>7}, "Neuroscience"=>{"Neuroscience"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}}, "reader_count_by_country"=>{"Ethiopia"=>1}, "group_count"=>0}

Scopus | Further Information

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Figshare

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  • {"files"=>["https://ndownloader.figshare.com/files/4229017"], "description"=>"<p>A: Boxplot presenting CoQ10 levels in the cerebellum of MSA, CBD, DLB, IPD, CRB_ATX and controls. B: Boxplot presenting CoQ10 levels in the cerebellum of MSA cases subdivided by pathological subtypes MSA_SND, MSA_mixed and MSA_OPCA, and also CRB_ATX cases subdivided into SCA, FRDA and other_ATX. C: Boxplot presenting CoQ10 levels in the frontal cortex of MSA, DLB, IPD, CRB_ATX and controls. D: Boxplot presenting CoQ10 levels in the frontal cortex of MSA cases subdivided by pathological subtypes MSA_SND, MSA_mixed and MSA_OPCA, and also CRB_ATX cases subdivided into SCA, FRDA and other_ATX. Each dot represents one individual, and dots beyond the boxplot whiskers represent outliers. Glossary: MSA = multiple system atrophy; MSA_SND = MSA striatonigral degeneration; MSA_mixed = MSA mixed; MSA_OPCA = MSA olivopontocerebellar atrophy; CBD = corticobasal degeneration; DLB = dementia with Lewy bodies; IPD = idiopathic Parkinson’s disease; CRB_ATX = cerebellar ataxia; SCA = spinocerebellar ataxia; FRDA = Friedreich’s ataxia; other_ATX = other ataxias of miscellaneous origin.</p>", "links"=>[], "tags"=>["Coenzyme Q 10 Levels", "atrophy", "SND", "coenzyme Q 10", "corticobasal", "brain tissue", "Parkinson", "neurodegenerative", "type", "cerebellar ataxia", "Lewy bodies", "CoQ 10 biosynthetic pathway", "6 striatonigral degeneration", "OPCA", "dementia", "MSA", "CoQ 10", "idiopathic"], "article_id"=>2583106, "categories"=>["Biochemistry", "Cell Biology", "Genetics", "Molecular Biology", "Neuroscience", "Physiology", "Biotechnology", "Developmental Biology", "Cancer", "Science Policy", "Infectious Diseases"], "users"=>["Lucia V. Schottlaender", "Conceição Bettencourt", "Aoife P. Kiely", "Annapurna Chalasani", "Viruna Neergheen", "Janice L. Holton", "Iain Hargreaves", "Henry Houlden"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0149557.g001", "stats"=>{"downloads"=>2, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Coenzyme_Q10_Levels_Are_Decreased_in_the_Cerebellum_of_Multiple_System_Atrophy_Patients_Fig_1/2583106", "title"=>"Coenzyme Q10 Levels Are Decreased in the Cerebellum of Multiple-System Atrophy Patients - Fig 1", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-02-19 14:58:58"}
  • {"files"=>["https://ndownloader.figshare.com/files/4229020"], "description"=>"<p>Characterization of the samples included in this study.</p>", "links"=>[], "tags"=>["Coenzyme Q 10 Levels", "atrophy", "SND", "coenzyme Q 10", "corticobasal", "brain tissue", "Parkinson", "neurodegenerative", "type", "cerebellar ataxia", "Lewy bodies", "CoQ 10 biosynthetic pathway", "6 striatonigral degeneration", "OPCA", "dementia", "MSA", "CoQ 10", "idiopathic"], "article_id"=>2583109, "categories"=>["Biochemistry", "Cell Biology", "Genetics", "Molecular Biology", "Neuroscience", "Physiology", "Biotechnology", "Developmental Biology", "Cancer", "Science Policy", "Infectious Diseases"], "users"=>["Lucia V. Schottlaender", "Conceição Bettencourt", "Aoife P. Kiely", "Annapurna Chalasani", "Viruna Neergheen", "Janice L. Holton", "Iain Hargreaves", "Henry Houlden"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0149557.t001", "stats"=>{"downloads"=>1, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Characterization_of_the_samples_included_in_this_study_/2583109", "title"=>"Characterization of the samples included in this study.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2016-02-19 14:58:58"}

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  • {"unique-ip"=>"7", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"8", "full-text"=>"11", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"14", "full-text"=>"21", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"8", "full-text"=>"11", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"9", "full-text"=>"16", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"11", "full-text"=>"10", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"10", "full-text"=>"8", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2019", "month"=>"9"}

Relative Metric

{"start_date"=>"2016-01-01T00:00:00Z", "end_date"=>"2016-12-31T00:00:00Z", "subject_areas"=>[]}
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