Ocular Dominance Plasticity after Stroke Was Preserved in PSD-95 Knockout Mice
Publication Date
March 01, 2016
Journal
PLOS ONE
Authors
Franziska Greifzu, Daniel Parthier, Bianka Goetze, Oliver M. Schlüter, et al
Volume
11
Issue
3
Pages
e0149771
DOI
https://dx.plos.org/10.1371/journal.pone.0149771
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0149771
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/26930616
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773175
Europe PMC
http://europepmc.org/abstract/MED/26930616
Web of Science
000371434500054
Scopus
84960971334
Mendeley
http://www.mendeley.com/research/ocular-dominance-plasticity-after-stroke-preserved-psd95-knockout-mice
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Mendeley | Further Information

{"title"=>"Ocular dominance plasticity after stroke was preserved in PSD-95 knockout mice", "type"=>"journal", "authors"=>[{"first_name"=>"Franziska", "last_name"=>"Greifzu", "scopus_author_id"=>"54401059000"}, {"first_name"=>"Daniel", "last_name"=>"Parthier", "scopus_author_id"=>"56442732400"}, {"first_name"=>"Bianka", "last_name"=>"Goetze", "scopus_author_id"=>"35573431900"}, {"first_name"=>"Oliver M.", "last_name"=>"Schlüter", "scopus_author_id"=>"6603596706"}, {"first_name"=>"Siegrid", "last_name"=>"Löwel", "scopus_author_id"=>"7003867966"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84960971334", "scopus"=>"2-s2.0-84960971334", "doi"=>"10.1371/journal.pone.0149771", "pui"=>"608996524", "issn"=>"19326203", "pmid"=>"26930616"}, "id"=>"7c138e11-d957-3f32-8231-2c645ed69548", "abstract"=>"Neuronal plasticity is essential to enable rehabilitation when the brain suffers from injury, such as following a stroke. One of the most established models to study cortical plasticity is ocular dominance (OD) plasticity in the primary visual cortex (V1) of the mammalian brain induced by monocular deprivation (MD). We have previously shown that OD-plasticity in adult mouse V1 is absent after a photothrombotic (PT) stroke lesion in the adjacent primary somatosensory cortex (S1). Exposing lesioned mice to conditions which reduce the inhibitory tone in V1, such as raising animals in an enriched environment or short-term dark exposure, preserved OD-plasticity after an S1-lesion. Here we tested whether modification of excitatory circuits can also be beneficial for preserving V1-plasticity after stroke. Mice lacking postsynaptic density protein-95 (PSD-95), a signaling scaffold present at mature excitatory synapses, have lifelong juvenile-like OD-plasticity caused by an increased number of AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) -silent synapses in V1 but unaltered inhibitory tone. In fact, using intrinsic signal optical imaging, we show here that OD-plasticity was preserved in V1 of adult PSD-95 KO mice after an S1-lesion but not in PSD-95 wildtype (WT)-mice. In addition, experience-enabled enhancement of the optomotor reflex of the open eye after MD was compromised in both lesioned PSD-95 KO and PSD-95 WT mice. Basic V1-activation and retinotopic map quality were, however, not different between lesioned PSD-95 KO mice and their WT littermates. The preserved OD-plasticity in the PSD-95 KO mice indicates that V1-plasticity after a distant stroke can be promoted by either changes in excitatory circuitry or by lowering the inhibitory tone in V1 as previously shown. Furthermore, the present data indicate that an increased number of AMPA-silent synapses preserves OD-plasticity not only in the healthy brain, but also in another experimental paradigm of cortical plasticity, namely the long-range influence on V1-plasticity after an S1-lesion.", "link"=>"http://www.mendeley.com/research/ocular-dominance-plasticity-after-stroke-preserved-psd95-knockout-mice", "reader_count"=>14, "reader_count_by_academic_status"=>{"Researcher"=>3, "Student > Ph. D. Student"=>2, "Student > Master"=>7, "Student > Bachelor"=>1, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_user_role"=>{"Researcher"=>3, "Student > Ph. D. Student"=>2, "Student > Master"=>7, "Student > Bachelor"=>1, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>1, "Agricultural and Biological Sciences"=>5, "Medicine and Dentistry"=>2, "Neuroscience"=>5, "Physics and Astronomy"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Neuroscience"=>{"Neuroscience"=>5}, "Physics and Astronomy"=>{"Physics and Astronomy"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>5}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}}, "reader_count_by_country"=>{"Germany"=>1}, "group_count"=>1}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/4799146"], "description"=>"<p>(A) Top view of a representative mouse brain illustrating the lesion location in S1, on average 1 mm anterior to the anterior border of the primary visual cortex (V1, blue dashed line). (B) Nissl-stained frontal section through the lesion (same animal as in A). (C) Higher magnification composite image of the superficial vascular pattern of the brain and the superimposed optically recorded retinotopic map of the binocular part of V1 of a PSD-95 KO mouse in which the PT-lesion (L) was very close to V1; nevertheless, OD-plasticity was present in this animal (average ODI = 0.00). Scale bar all, 1 mm.</p>", "links"=>[], "tags"=>["WT", "synapses", "adult mouse V 1", "Ocular Dominance Plasticity", "OD", "plasticity", "MD", "retinotopic map quality", "AMPA", "PSD", "tone", "V 1", "KO", "stroke", "lesioned", "PT"], "article_id"=>3086989, "categories"=>["Cell Biology", "Neuroscience", "Physiology", "Biological Sciences not elsewhere classified", "Mental Health", "Infectious Diseases"], "users"=>["Franziska Greifzu", "Daniel Parthier", "Bianka Goetze", "Oliver M. Schlüter", "Siegrid Löwel"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0149771.g001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Location_of_the_photothrombotically_induced_cortical_stroke_lesion_in_a_PSD_95_KO_mouse_in_S1_PT_red_dashed_line_/3086989", "title"=>"Location of the photothrombotically induced cortical stroke lesion in a PSD-95 KO mouse in S1 (PT, red dashed line).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-03-01 06:46:50"}
  • {"files"=>["https://ndownloader.figshare.com/files/4799398"], "description"=>"<p>In contrast, enhancements of spatial vision were present in nonlesioned PSD-95 WT and PSD-95 KO mice. (A, B) Spatial frequency threshold of the optomotor response of the open eye in cycles per degree (cyc/deg) plotted against days after MD. After 7 days of MD, nonlesioned PSD-95 KO mice (A) as well as sham-treated control mice (B; data from Greifzu et al., 2011) showed a significant increase in the spatial frequency threshold of the optomotor reflex of the open eye. This experience-enabled increase was abolished by a PT in S1 (A, B). (C-F) Contrast sensitivity thresholds of the optomotor reflex of the open eye at 6 different spatial frequencies before (day 0) and 7 days after MD. For both nonlesioned PSD-95 KO (C) and PSD-95 WT mice (D), there was an increase in contrast sensitivity after 7 days of MD. After PT, this experience-enabled increase was absent in both groups (E, F).</p>", "links"=>[], "tags"=>["WT", "synapses", "adult mouse V 1", "Ocular Dominance Plasticity", "OD", "plasticity", "MD", "retinotopic map quality", "AMPA", "PSD", "tone", "V 1", "KO", "stroke", "lesioned", "PT"], "article_id"=>3087133, "categories"=>["Cell Biology", "Neuroscience", "Physiology", "Biological Sciences not elsewhere classified", "Mental Health", "Infectious Diseases"], "users"=>["Franziska Greifzu", "Daniel Parthier", "Bianka Goetze", "Oliver M. Schlüter", "Siegrid Löwel"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0149771.g003", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/The_experience_enabled_enhancement_of_the_optomotor_reflex_of_the_open_eye_after_monocular_deprivation_MD_was_compromised_in_both_PT_lesioned_PSD_95_WT_and_PSD_95_KO_mice_/3087133", "title"=>"The experience-enabled enhancement of the optomotor reflex of the open eye after monocular deprivation (MD) was compromised in both PT-lesioned PSD-95 WT and PSD-95 KO mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-03-01 06:46:50"}
  • {"files"=>["https://ndownloader.figshare.com/files/4799239"], "description"=>"<p>Optically recorded activity maps of the contralateral (contra) and ipsilateral (ipsi) eye in the binocular region of mouse primary visual cortex (V1) in PT-lesioned PSD-95 WT (A) and PSD-95 KO mice (B) after monocular deprivation (MD), and their quantification (C, D). Open and closed eyes indicated by a white or black circle. (A, B) Grayscale coded response magnitude maps of the contra- and ipsilateral eye (including average V1-activation of the illustrated example) and the histogram of OD-scores including the average OD-index (top row), color-coded polar maps of retinotopy and 2-dimensional OD-maps after MD (lower row) are illustrated. (A) In PSD-95 WT littermates, activity patches evoked by stimulation of the contralateral eye were darker than those of the ipsilateral eye, the average ODI was positive, and warm colors prevailed in the OD-maps, indicating contralateral dominance. In contrast, in PSD-95 KO mice, the contra- and ipsilateral eye activated V1 about equally strong, colder colors appeared in the OD-map, and the histogram of OD-scores shifted to the left (B). Scale bar: 1 mm. (C) Optically imaged OD-indices in PT-lesioned PSD-95 WT and PSD-95 KO mice (light red and red triangles). For comparison, ODIs of control (sham-treated) and PT-lesioned Bl6/J mice are illustrated (white and grey squares). Symbols represent ODI values of individuals, means are marked by horizontal lines. (D) V1-activation elicited by stimulation of the contralateral (C) or ipsilateral (I) eye in PSD-95 WT and PSD-95 KO mice after PT and MD. Note that V1-activtation after stimulation of the contra- and ipsilateral eye was not different in PSD-95 KO mice, indicating preserved juvenile-like OD-plasticity in V1 despite the S1-lesion.</p>", "links"=>[], "tags"=>["WT", "synapses", "adult mouse V 1", "Ocular Dominance Plasticity", "OD", "plasticity", "MD", "retinotopic map quality", "AMPA", "PSD", "tone", "V 1", "KO", "stroke", "lesioned", "PT"], "article_id"=>3087055, "categories"=>["Cell Biology", "Neuroscience", "Physiology", "Biological Sciences not elsewhere classified", "Mental Health", "Infectious Diseases"], "users"=>["Franziska Greifzu", "Daniel Parthier", "Bianka Goetze", "Oliver M. Schlüter", "Siegrid Löwel"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0149771.g002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/In_adult_PSD_95_KO_mice_ocular_dominance_plasticity_was_preserved_after_a_PT_stroke_in_S1_/3087055", "title"=>"In adult PSD-95 KO mice, ocular dominance plasticity was preserved after a PT-stroke in S1.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-03-01 06:46:50"}

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Relative Metric

{"start_date"=>"2016-01-01T00:00:00Z", "end_date"=>"2016-12-31T00:00:00Z", "subject_areas"=>[]}
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