Emx1 Is Required for Neocortical Area Patterning
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{"title"=>"Emx1 is required for neocortical area patterning", "type"=>"journal", "authors"=>[{"first_name"=>"Adam M.", "last_name"=>"Stocker", "scopus_author_id"=>"12780969400"}, {"first_name"=>"Dennis D.M.", "last_name"=>"O'Leary", "scopus_author_id"=>"7201977878"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"608919233", "scopus"=>"2-s2.0-84960539704", "issn"=>"19326203", "pmid"=>"26901526", "sgr"=>"84960539704", "doi"=>"10.1371/journal.pone.0149900"}, "id"=>"fe6eab0b-1165-339d-a116-5d63e04aa0e8", "abstract"=>"Establishing appropriate area patterning in the neocortex is a critical developmental event, and transcription factors whose expression is graded across the developing neural axes have been implicated in this process. While previous reports suggested that the transcrip- tion factor Emx1 does not contribute to neocortical area patterning, those studies were per- formed at perinatal ages prior to the emergence of primary areas.We therefore examined two different Emx1 deletion mouse lines once primary areas possessmature features. Fol- lowing the deletion of Emx1, the frontal and motor areas were expanded while the primary visual area was reduced, and overall the areas shifted posterio-medially. This patterning phenotype was consistent between the two Emx1 deletion strategies. The present study demonstrates that Emx1 is an area patterning transcription factor and is required for the specification of the primary visual area. Introduction", "link"=>"http://www.mendeley.com/research/emx1-required-neocortical-area-patterning", "reader_count"=>13, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Researcher"=>3, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1, "Student > Master"=>2, "Student > Bachelor"=>2, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Researcher"=>3, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1, "Student > Master"=>2, "Student > Bachelor"=>2, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>1, "Agricultural and Biological Sciences"=>6, "Medicine and Dentistry"=>1, "Neuroscience"=>4}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Neuroscience"=>{"Neuroscience"=>4}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>6}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"Netherlands"=>1}, "group_count"=>0}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/4412398"], "description"=>"<p>Immunostaining and in situ hybridization for several markers was performed on sagittal sections of P7 cortices. (A) Schematic of a sagittal section detailing the cortical layers and location of the hippocampus (Hipp). Stained sections of wt (B–E), Emx1<sup>-/-</sup> (F–I), and Emx1<sup>cre/-</sup> (J–M) have been cropped to highlight changes in V1. (B, F, J) 5HT immunostaining revealed layer 4 of V1 and S1. Compared to wt, Emx1 deletions (Emx1<sup>-/-</sup> and Emx1<sup>cre/-</sup>) possessed a smaller, posteriorly shifted V1 (black arrowheads denote anterior edge of V1, gray arrowheads denote posterior edge of S1). (C, G, K) RORβ is expressed in layer 4 of primary sensory areas. In Emx1 deletions the posterior shift of the anterior edge of V1 (black arrowheads) and posterior edge of S1 (gray arrowheads) can be appreciated, showing the reduction in V1 size. (D, H, L) Id2 is expressed in layer 5 of V1 and also showed a posterior shift of the anterior edge of V1 in Emx1 deletions (arrowheads). (E, I, M) Cad8 is expressed in layers 2/3 of V1, and in Emx1 deletions the anterior edge of V1 (arrowheads) was shifted posteriorly, and V1 size was reduced. Cad8 is also expressed in the hippocampus, which is ventral to the cortex and provides a stable landmark for comparison between genotypes. All of the stains presented demonstrated the reduction of V1 in the sagittal plane, as well as the posterior shift of V1. However all of these markers were expressed in the appropriate cortical layers. Anterior is to the left, dorsal to the top. V1, primary visual area; S1, primary somatosensory area; Hipp, hippocampus; ant, anterior; pos, posterior. Scale bar, 1.0 mm. Bar in B applies to all panels.</p>", "links"=>[], "tags"=>["Emx 1 deletion mouse lines", "transcription factor Emx 1", "Emx 1", "area patterning transcription factor", "neocortical area patterning", "Neocortical Area Patterning", "Emx 1 deletion strategies"], "article_id"=>2735665, "categories"=>["Cell Biology", "Genetics", "Environmental Sciences not elsewhere classified", "Biological Sciences not elsewhere classified", "Developmental Biology", "Science Policy", "Infectious Diseases", "Plant Biology"], "users"=>["Adam M. Stocker", "Dennis D. M. O’Leary"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0149900.g001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Gene_expression_demonstrates_a_reduction_in_V1_size_with_normal_laminar_expression_following_Emx1_deletion_/2735665", "title"=>"Gene expression demonstrates a reduction in V1 size with normal laminar expression following Emx1 deletion.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-02-22 10:02:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/4412419"], "description"=>"<p>Whole mount in situ hybridization (WMISH) was performed on P7 cortices to observe changes in area patterning following Emx1 deletion. (A–C) Examples of fixed, unstained P7 cortices from each genotype. (D) Analysis of cortical area demonstrated that both Emx1 deletions possessed cortices smaller than wt. (E–G) Cad8 expression labels F-M and V1 (both outlined). (H) V1 area was normalized by total cortical area, and the relative V1 area size in both Emx1<sup>-/-</sup> and Emx1<sup>cre/-</sup> cortices, as measured by Cad8, was significantly smaller than wt. (I) F-M was normalized by total cortical area, and the relative F-M area size in both Emx1<sup>-/-</sup> and Emx1<sup>cre/-</sup> cortices, as measured by Cad8, was significantly larger than wt. (J–L) Lmo4 marks V1 (outlined) and S1 with lower expression relative to surrounding regions and was highly expressed in F-M areas (outlined). (M) Lmo4 V1 relative area in both Emx1<sup>-/-</sup> and Emx1<sup>cre/-</sup> cortices was significantly smaller than wt. (N) Lmo4 F-M relative area in both Emx1<sup>-/-</sup> and Emx1<sup>cre/-</sup> cortices was significantly larger than wt. (O–Q) Igfbp5 expression labels V1, thus only the posterio-medial portion of P7 cortices are shown, as indicated in the schematic. (R) Igfbp5 V1 relative area in both Emx1<sup>-/-</sup> and Emx1<sup>cre/-</sup> cortices was significantly smaller than wt. Data presented as percentage of wt. V1, primary visual area; S1, primary somatosensory area; F-M, frontal and motor areas. *P<0.05; **P<0.01; ***P<0.001; Tukey’s HSD post hoc test. Scale bar, 1.0 mm. Bar in A applies to A–C, E–G, J–L. Bar in O applies to O–Q.</p>", "links"=>[], "tags"=>["Emx 1 deletion mouse lines", "transcription factor Emx 1", "Emx 1", "area patterning transcription factor", "neocortical area patterning", "Neocortical Area Patterning", "Emx 1 deletion strategies"], "article_id"=>2735683, "categories"=>["Cell Biology", "Genetics", "Environmental Sciences not elsewhere classified", "Biological Sciences not elsewhere classified", "Developmental Biology", "Science Policy", "Infectious Diseases", "Plant Biology"], "users"=>["Adam M. Stocker", "Dennis D. M. O’Leary"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0149900.g002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Gene_expression_demonstrates_reduction_in_V1_and_expansion_of_F_M_in_Emx1_deleted_animals_/2735683", "title"=>"Gene expression demonstrates reduction in V1 and expansion of F-M in Emx1 deleted animals.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-02-22 10:02:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/4412434"], "description"=>"<p>Labeling of geniculocortical projections was performed by placing DiI crystals into the primary visual thalamic nucleus (dorsal lateral geniculate, dLG). (A) Sagittal schematic of DiI label placement (pink arrowhead) and visual sensory connections between cortex and thalamus (red), as well as somatosensory connections between cortex (S1) and thalamus (ventral posterior nucleus, VP) in gray. The highlighted region in this schematic is presented in subsequent panels. Sagittal sections through wt (B), Emx1<sup>-/-</sup> (C), and Emx1<sup>cre/-</sup> (D) brains, where the distribution of DiI labeled geniculocortical projections is shown in red. Tissue has been counterstained with DAPI (blue) to reveal gross anatomic structure of the sections. The distribution of labeled projections in both Emx1 deletions reveal that V1 was reduced and its anterior border (arrowhead) has been shifted posteriorly. Labeling also showed that geniculocortical projections from the dLG correctly targeted the reduced V1 and did not ectopically project to S1 or other sensory areas in both Emx1 deletions. V1, primary visual area; S1, primary somatosensory area; dLG, dorsal lateral geniculate (visual thalamic nucleus); VP, ventral posterior (somatosensory thalamic nucleus). Anterior is to the left, dorsal to the top. Scale bar, 1.0 mm, applies to B–D.</p>", "links"=>[], "tags"=>["Emx 1 deletion mouse lines", "transcription factor Emx 1", "Emx 1", "area patterning transcription factor", "neocortical area patterning", "Neocortical Area Patterning", "Emx 1 deletion strategies"], "article_id"=>2735704, "categories"=>["Cell Biology", "Genetics", "Environmental Sciences not elsewhere classified", "Biological Sciences not elsewhere classified", "Developmental Biology", "Science Policy", "Infectious Diseases", "Plant Biology"], "users"=>["Adam M. Stocker", "Dennis D. M. O’Leary"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0149900.g004", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Geniculocortical_projections_to_V1_correctly_match_the_reduced_size_of_V1_in_Emx1_deletions_/2735704", "title"=>"Geniculocortical projections to V1 correctly match the reduced size of V1 in Emx1 deletions.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-02-22 10:02:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/4412377"], "description"=>"<div><p>Establishing appropriate area patterning in the neocortex is a critical developmental event, and transcription factors whose expression is graded across the developing neural axes have been implicated in this process. While previous reports suggested that the transcription factor Emx1 does not contribute to neocortical area patterning, those studies were performed at perinatal ages prior to the emergence of primary areas. We therefore examined two different Emx1 deletion mouse lines once primary areas possess mature features. Following the deletion of Emx1, the frontal and motor areas were expanded while the primary visual area was reduced, and overall the areas shifted posterio-medially. This patterning phenotype was consistent between the two Emx1 deletion strategies. The present study demonstrates that Emx1 is an area patterning transcription factor and is required for the specification of the primary visual area.</p></div>", "links"=>[], "tags"=>["Emx 1 deletion mouse lines", "transcription factor Emx 1", "Emx 1", "area patterning transcription factor", "neocortical area patterning", "Neocortical Area Patterning", "Emx 1 deletion strategies"], "article_id"=>2735644, "categories"=>["Cell Biology", "Genetics", "Environmental Sciences not elsewhere classified", "Biological Sciences not elsewhere classified", "Developmental Biology", "Science Policy", "Infectious Diseases", "Plant Biology"], "users"=>["Adam M. Stocker", "Dennis D. M. O’Leary"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0149900", "stats"=>{"downloads"=>1, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Emx1_Is_Required_for_Neocortical_Area_Patterning/2735644", "title"=>"Emx1 Is Required for Neocortical Area Patterning", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2016-02-22 10:02:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/4412428"], "description"=>"<p>RORβ is expressed in layer 4 of sensory areas shown here on tangential sections of flattened P7 cortices of wt (A), Emx1<sup>-/-</sup> (B), and Emx1<sup>cre/-</sup> (C) animals. The changes observed in tangential sections were the same seen in the sagittal plane (<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0149900#pone.0149900.g001\" target=\"_blank\">Fig 1</a>) and WMISH (<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0149900#pone.0149900.g002\" target=\"_blank\">Fig 2</a>). (D–F) 5HT immunostaining highlighting thalamic terminations on tangential sections of flattened P7 cortex. 5HT staining was utilized to examine area patterning changes in thalamocortical innervation, which were the same as those seen by RORβ expression (A–C). All quantifications were performed using 5HT stained sections. (G) Total cortical area was measured (outlined in wt sections, gray in schematic), and both Emx1<sup>-/-</sup> and Emx1<sup>cre/-</sup> 5HT stained cortices were significantly smaller than wt. (H) V1 area (outlined in sections, gray in schematic) was significantly smaller in both Emx1<sup>-/-</sup> and Emx1<sup>cre/-</sup> cortices than wt. (I) V1 area (outlined in sections, light gray in schematic) was normalized by total cortical area (dark gray in schematic), and V1 area relative size in both Emx1<sup>-/-</sup> and Emx1<sup>cre/-</sup> cortices was significantly smaller than wt. (J) F-M area (outlined in sections, light gray in schematic) was normalized by total cortical area (dark gray in schematic), and F-M area relative size in both Emx1<sup>-/-</sup> and Emx1<sup>cre/-</sup> cortices was significantly larger than wt. (K) PMBSF (outlined in sections, light gray in schematic) was normalized by total cortical area (dark gray in schematic), and PMBSF area relative size was the same between all genotypes. (L) The length from the C3 barrel to the caudal pole (red line in schematic) was normalized by total cortical length (blue line in schematic), and relative C3 length in both Emx1<sup>-/-</sup> and Emx1<sup>cre/-</sup> cortices was significantly smaller than wt. (M) The width from the C3 barrel to the medial edge (red line in schematic) was normalized by total cortical width (blue line in schematic), and the relative C3 width in both Emx1<sup>-/-</sup> and Emx1<sup>cre/-</sup> cortices was significantly smaller than wt. Data presented as percentage of wt measurements. V1, primary visual area; PMBSF, posteromedial barrel subfield of the primary somatosensory area; arrow points to C3 barrel location within PMBSF; F-M, frontal and motor areas. Medial to the left, anterior to the top. *P<0.05; **P<0.01; ***P<0.001; Tukey’s HSD post-hoc test. Scale bar, 1.0 mm. Bar in A applies to A–C; bar in D applies to D–F.</p>", "links"=>[], "tags"=>["Emx 1 deletion mouse lines", "transcription factor Emx 1", "Emx 1", "area patterning transcription factor", "neocortical area patterning", "Neocortical Area Patterning", "Emx 1 deletion strategies"], "article_id"=>2735692, "categories"=>["Cell Biology", "Genetics", "Environmental Sciences not elsewhere classified", "Biological Sciences not elsewhere classified", "Developmental Biology", "Science Policy", "Infectious Diseases", "Plant Biology"], "users"=>["Adam M. Stocker", "Dennis D. M. O’Leary"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0149900.g003", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Thalamic_terminations_demonstrate_changes_in_primary_area_size_in_tangential_sections_following_Emx1_deletion_/2735692", "title"=>"Thalamic terminations demonstrate changes in primary area size in tangential sections following Emx1 deletion.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-02-22 10:02:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/4412464"], "description"=>"<p>Schema of primary sensory and motor areas in the wild type neocortex (control), the homozygous Emx1 deletion neocortex (both approaches), and the heterozygous Emx2 deletion neocortex. All of the data presented in this study have demonstrated that following Emx1 deletion, V1 was reduced in size and F-M was expanded, while S1 was shifted posteriorly. This patterning phenotype was observed in both the Emx1<sup>-/-</sup> and Emx1<sup>cre/-</sup> mouse lines. These changes were very similar to those observed in Emx2 heterozygous mutants [<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0149900#pone.0149900.ref013\" target=\"_blank\">13</a>]. Our results demonstrate that Emx1 is an intrinsic area patterning transcription factor and is required for V1 specification. A, anterior; L, lateral; V1, primary visual area; S1, primary somatosensory area; A1, primary auditory; F-M, frontal and motor areas.</p>", "links"=>[], "tags"=>["Emx 1 deletion mouse lines", "transcription factor Emx 1", "Emx 1", "area patterning transcription factor", "neocortical area patterning", "Neocortical Area Patterning", "Emx 1 deletion strategies"], "article_id"=>2735725, "categories"=>["Cell Biology", "Genetics", "Environmental Sciences not elsewhere classified", "Biological Sciences not elsewhere classified", "Developmental Biology", "Science Policy", "Infectious Diseases", "Plant Biology"], "users"=>["Adam M. Stocker", "Dennis D. M. O’Leary"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0149900.g005", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Summary_of_neocortical_area_patterning_changes_following_Emx1_deletion_/2735725", "title"=>"Summary of neocortical area patterning changes following Emx1 deletion.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-02-22 10:02:59"}

PMC Usage Stats | Further Information

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  • {"unique-ip"=>"19", "full-text"=>"17", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"14", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"14", "full-text"=>"12", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"17", "full-text"=>"14", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"16", "full-text"=>"10", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"16", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"18", "full-text"=>"16", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"13", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"15", "full-text"=>"14", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"18", "full-text"=>"20", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"5", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"12", "full-text"=>"13", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"23", "full-text"=>"21", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"12", "full-text"=>"14", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"20", "full-text"=>"18", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"15", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"19", "full-text"=>"17", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"18", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"23", "full-text"=>"21", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"16", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"14", "full-text"=>"12", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"2"}
  • {"unique-ip"=>"14", "full-text"=>"13", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"19", "full-text"=>"21", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"16", "full-text"=>"15", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"15", "full-text"=>"13", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"9", "full-text"=>"10", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"14", "full-text"=>"15", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"19", "full-text"=>"19", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"19", "full-text"=>"19", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"13", "full-text"=>"14", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"20", "full-text"=>"23", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"16", "full-text"=>"16", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}

Relative Metric

{"start_date"=>"2016-01-01T00:00:00Z", "end_date"=>"2016-12-31T00:00:00Z", "subject_areas"=>[]}
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