Phenolic Compounds in Extra Virgin Olive Oil Stimulate Human Osteoblastic Cell Proliferation
Publication Date
March 01, 2016
Journal
PLOS ONE
Authors
Olga García Martínez, Elvira De Luna Bertos, Javier Ramos Torrecillas, Concepción Ruiz, et al
Volume
11
Issue
3
Pages
e0150045
DOI
https://dx.plos.org/10.1371/journal.pone.0150045
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0150045
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/26930190
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773235
Europe PMC
http://europepmc.org/abstract/MED/26930190
Web of Science
000371434500092
Scopus
84960927662
Mendeley
http://www.mendeley.com/research/phenolic-compounds-extra-virgin-olive-oil-stimulate-human-osteoblastic-cell-proliferation-4
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Mendeley | Further Information

{"title"=>"Phenolic compounds in extra virgin olive oil stimulate human osteoblastic cell proliferation", "type"=>"journal", "authors"=>[{"first_name"=>"Olga", "last_name"=>"García-Martínez", "scopus_author_id"=>"6601970099"}, {"first_name"=>"Elvira", "last_name"=>"De Luna-Bertos", "scopus_author_id"=>"36631706700"}, {"first_name"=>"Javier", "last_name"=>"Ramos-Torrecillas", "scopus_author_id"=>"47661616100"}, {"first_name"=>"Concepción", "last_name"=>"Ruiz", "scopus_author_id"=>"7202458742"}, {"first_name"=>"Egle", "last_name"=>"Milia", "scopus_author_id"=>"6701623097"}, {"first_name"=>"María Luisa", "last_name"=>"Lorenzo", "scopus_author_id"=>"7102875459"}, {"first_name"=>"Brigida", "last_name"=>"Jimenez", "scopus_author_id"=>"55616014400"}, {"first_name"=>"Araceli", "last_name"=>"Sánchez-Ortiz", "scopus_author_id"=>"24470240100"}, {"first_name"=>"Ana", "last_name"=>"Rivas", "scopus_author_id"=>"7005714924"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"26930190", "doi"=>"10.1371/journal.pone.0150045", "sgr"=>"84960927662", "isbn"=>"1932-6203", "scopus"=>"2-s2.0-84960927662", "issn"=>"19326203", "pui"=>"608947674"}, "id"=>"62d1158d-cbbd-306d-bd30-e7c1a85bdbfe", "abstract"=>"In this study, we aimed to clarify the effects of phenolic compounds and extracts from different extra virgin olive oil (EVOO) varieties obtained from fruits of different ripening stages on osteoblast cells (MG-63) proliferation. Cell proliferation was increased by hydroxytyrosol, luteolin, apigenin, p-coumaric, caffeic, and ferulic acids by approximately 11-16%, as compared with controls that were treated with one vehicle alone, while (+)-pinoresinol, oleuropein, sinapic, vanillic acid and derivative (vanillin) did not affect cell proliferation. All phenolic extracts stimulated MG-63 cell growth, and they induced higher cell proliferation rates than individual compounds. The most effective EVOO phenolic extracts were those obtained from the Picual variety, as they significantly increased cell proliferation by 18-22%. Conversely, Arbequina phenolic extracts increased cell proliferation by 9-13%. A decline in osteoblast proliferation was observed in oils obtained from olive fruits collected at the end of the harvest period, as their total phenolic content decreases at this late stage. Further research on the signaling pathways of olive oil phenolic compounds involved in the processes and their metabolism should be carried out to develop new interventions and adjuvant therapies using EVOO for bone health (i.e.osteoporosis) in adulthood and the elderly.", "link"=>"http://www.mendeley.com/research/phenolic-compounds-extra-virgin-olive-oil-stimulate-human-osteoblastic-cell-proliferation-4", "reader_count"=>25, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Researcher"=>4, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>6, "Student > Master"=>5, "Student > Bachelor"=>7, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Researcher"=>4, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>6, "Student > Master"=>5, "Student > Bachelor"=>7, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Biochemistry, Genetics and Molecular Biology"=>3, "Nursing and Health Professions"=>4, "Medicine and Dentistry"=>5, "Agricultural and Biological Sciences"=>3, "Neuroscience"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Chemistry"=>5}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>5}, "Neuroscience"=>{"Neuroscience"=>1}, "Chemistry"=>{"Chemistry"=>5}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>4}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Unspecified"=>{"Unspecified"=>3}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "group_count"=>1}

Scopus | Further Information

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Figshare

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  • {"files"=>["https://ndownloader.figshare.com/files/4799650"], "description"=>"<p>Cells were treated with various concentrations of EVOO phenolic extract or vehicle alone (control) for 24 h. Data are means, with standard error of the mean shown by vertical bars of three separate experiments and at least every experiment was performed in triplicate. Mean values were significantly different as compared with control groups: *p<0.05, **p<0.01.</p>", "links"=>[], "tags"=>["Arbequina phenolic extracts", "cell proliferation rates", "Extra Virgin Olive Oil Stimulate Human Osteoblastic Cell Proliferation", "oil phenolic compounds", "MG", "phenolic content decreases", "cell proliferation", "EVOO phenolic extracts"], "article_id"=>3087316, "categories"=>["Biochemistry", "Cell Biology", "Molecular Biology", "Biotechnology", "Environmental Sciences not elsewhere classified", "Chemical Sciences not elsewhere classified", "Ecology", "Biological Sciences not elsewhere classified", "Developmental Biology"], "users"=>["Olga García-Martínez", "Elvira De Luna-Bertos", "Javier Ramos-Torrecillas", "Concepción Ruiz", "Egle Milia", "María Luisa Lorenzo", "Brigida Jimenez", "Araceli Sánchez-Ortiz", "Ana Rivas"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0150045.g001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Effect_of_EVOO_phenolic_extracts_on_the_growth_of_MG_63_cells_as_determined_by_MTT_/3087316", "title"=>"Effect of EVOO phenolic extracts on the growth of MG-63 cells as determined by MTT.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-03-01 06:49:20"}
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Relative Metric

{"start_date"=>"2016-01-01T00:00:00Z", "end_date"=>"2016-12-31T00:00:00Z", "subject_areas"=>[]}
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