Mechanical Conflict System: A Novel Operant Method for the Assessment of Nociceptive Behavior
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Figshare

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  • {"files"=>["https://ndownloader.figshare.com/files/4738228", "https://ndownloader.figshare.com/files/4738252"], "description"=>"<div><p>A new operant test for preclinical pain research, termed the Mechanical Conflict System (MCS), is presented. Rats were given a choice either to remain in a brightly lit compartment or to escape to a dark compartment by crossing an array of height-adjustable nociceptive probes. Latency to escape the light compartment was evaluated with varying probe heights (0, .5, 1, 2, 3, and 4 mm above compartment floor) in rats with neuropathic pain induced by constriction nerve injury (CCI) and in naive control rats. Escape responses in CCI rats were assessed following intraperitoneal administration of pregabalin (10 and 30 mg/kg), morphine (2.5 and 5 mg/kg), and the tachykinin NK1 receptor antagonist, RP 67580 (1 and 10 mg/kg). Results indicate that escape latency increased as a function of probe height in both naive and CCI rats. Pregabalin (10 and 30 mg/kg) and morphine (5 mg/kg), but not RP 67580, decreased latency to escape in CCI rats suggesting an antinociceptive effect. In contrast, morphine (10 mg/kg) but not pregabalin (30 mg/kg) increased escape latency in naive rats suggesting a possible anxiolytic action of morphine in response to light-induced fear. No order effects following multiple test sessions were observed. We conclude that the MCS is a valid method to assess behavioral signs of affective pain in rodents.</p></div>", "links"=>[], "tags"=>["probe", "RP", "tachykinin NK 1 receptor antagonist", "constriction nerve injury", "Novel Operant Method", "mg", "compartment", "CCI rats", "Mechanical Conflict System", "morphine", "MCS"], "article_id"=>3035497, "categories"=>["Biophysics", "Cell Biology", "Genetics", "Molecular Biology", "Neuroscience", "Pharmacology", "Biological Sciences not elsewhere classified", "Science Policy", "Mental Health", "Infectious Diseases"], "users"=>["Steven E. Harte", "Jessica B. Meyers", "Renee R. Donahue", "Bradley K. Taylor", "Thomas J. Morrow"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0150164.s001", "https://dx.doi.org/10.1371/journal.pone.0150164.s002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Mechanical_Conflict_System_A_Novel_Operant_Method_for_the_Assessment_of_Nociceptive_Behavior/3035497", "title"=>"Mechanical Conflict System: A Novel Operant Method for the Assessment of Nociceptive Behavior", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2016-02-25 11:17:50"}
  • {"files"=>["https://ndownloader.figshare.com/files/4738360"], "description"=>"<p><b>Panel A</b> shows a front view of the complete Mechanical Conflict System highlighting key components of the apparatus. <b>Panel B</b> shows a close-up of the nociceptive probe array with probes extended above the probe compartment floor.</p>", "links"=>[], "tags"=>["probe", "RP", "tachykinin NK 1 receptor antagonist", "constriction nerve injury", "Novel Operant Method", "mg", "compartment", "CCI rats", "Mechanical Conflict System", "morphine", "MCS"], "article_id"=>3035560, "categories"=>["Biophysics", "Cell Biology", "Genetics", "Molecular Biology", "Neuroscience", "Pharmacology", "Biological Sciences not elsewhere classified", "Science Policy", "Mental Health", "Infectious Diseases"], "users"=>["Steven E. Harte", "Jessica B. Meyers", "Renee R. Donahue", "Bradley K. Taylor", "Thomas J. Morrow"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0150164.g001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Mechanical_Conflict_System_/3035560", "title"=>"Mechanical Conflict System.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-02-25 11:17:50"}
  • {"files"=>["https://ndownloader.figshare.com/files/4738546"], "description"=>"<p>Escape latency is essentially unchanged for sessions where stimuli are presented 0 mm first / 4mm last (n = 6) or 0 mm last / 4mm first (n = 8).</p>", "links"=>[], "tags"=>["probe", "RP", "tachykinin NK 1 receptor antagonist", "constriction nerve injury", "Novel Operant Method", "mg", "compartment", "CCI rats", "Mechanical Conflict System", "morphine", "MCS"], "article_id"=>3035689, "categories"=>["Biophysics", "Cell Biology", "Genetics", "Molecular Biology", "Neuroscience", "Pharmacology", "Biological Sciences not elsewhere classified", "Science Policy", "Mental Health", "Infectious Diseases"], "users"=>["Steven E. Harte", "Jessica B. Meyers", "Renee R. Donahue", "Bradley K. Taylor", "Thomas J. Morrow"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0150164.g003", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Exit_latency_is_unaffected_across_multiple_test_sessions_and_by_the_order_in_which_test_stimuli_are_presented_/3035689", "title"=>"Exit latency is unaffected across multiple test sessions and by the order in which test stimuli are presented.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-02-25 11:17:50"}
  • {"files"=>["https://ndownloader.figshare.com/files/4738447"], "description"=>"<p>As probe height increases, escape latency also increases in both experimental groups. Escape latencies of CCI rats are greater than those of naive controls. # <i>p</i> < .05 between groups; * <i>p</i> < .05 compared to 0 mm; *** <i>p</i> < .001 compared to 0 mm.</p>", "links"=>[], "tags"=>["probe", "RP", "tachykinin NK 1 receptor antagonist", "constriction nerve injury", "Novel Operant Method", "mg", "compartment", "CCI rats", "Mechanical Conflict System", "morphine", "MCS"], "article_id"=>3035626, "categories"=>["Biophysics", "Cell Biology", "Genetics", "Molecular Biology", "Neuroscience", "Pharmacology", "Biological Sciences not elsewhere classified", "Science Policy", "Mental Health", "Infectious Diseases"], "users"=>["Steven E. Harte", "Jessica B. Meyers", "Renee R. Donahue", "Bradley K. Taylor", "Thomas J. Morrow"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0150164.g002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Stimulus_response_relationship_of_latency_to_escape_the_light_compartment_as_a_function_of_probe_height_between_naive_and_CCI_rats_n_7_per_group_/3035626", "title"=>"Stimulus response relationship of latency to escape the light compartment as a function of probe height between naive and CCI rats (n = 7 per group).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-02-25 11:17:50"}
  • {"files"=>["https://ndownloader.figshare.com/files/4738627"], "description"=>"<p>Compared to vehicle administration, pregabalin (<b>Panel A</b>, n = 14) and morphine (<b>Panel B</b>, n = 9) but not RP 67580 (<b>Panel C</b>, n = 9) effectively reduced escape latency in CCI rats. * <i>p</i> < .05 compared to vehicle; ** <i>p</i> < .01 compared to vehicle.</p>", "links"=>[], "tags"=>["probe", "RP", "tachykinin NK 1 receptor antagonist", "constriction nerve injury", "Novel Operant Method", "mg", "compartment", "CCI rats", "Mechanical Conflict System", "morphine", "MCS"], "article_id"=>3035755, "categories"=>["Biophysics", "Cell Biology", "Genetics", "Molecular Biology", "Neuroscience", "Pharmacology", "Biological Sciences not elsewhere classified", "Science Policy", "Mental Health", "Infectious Diseases"], "users"=>["Steven E. Harte", "Jessica B. Meyers", "Renee R. Donahue", "Bradley K. Taylor", "Thomas J. Morrow"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0150164.g004", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Effect_of_vehicle_and_drug_administration_on_the_escape_latency_of_CCI_rats_impeded_by_3_mm_probes_/3035755", "title"=>"Effect of vehicle and drug administration on the escape latency of CCI rats impeded by 3 mm probes.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-02-25 11:17:50"}

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Relative Metric

{"start_date"=>"2016-01-01T00:00:00Z", "end_date"=>"2016-12-31T00:00:00Z", "subject_areas"=>[]}
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