Deformability Assessment of Waterborne Protozoa Using a Microfluidic-Enabled Force Microscopy Probe
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{"title"=>"Deformability assessment of waterborne protozoa using a microfluidic-enabled force microscopy probe", "type"=>"journal", "authors"=>[{"first_name"=>"John S.", "last_name"=>"McGrath", "scopus_author_id"=>"57188582377"}, {"first_name"=>"Jos", "last_name"=>"Quist", "scopus_author_id"=>"57188689962"}, {"first_name"=>"James R.T.", "last_name"=>"Seddon", "scopus_author_id"=>"7103239728"}, {"first_name"=>"Stanley C.S.", "last_name"=>"Lai", "scopus_author_id"=>"57188691132"}, {"first_name"=>"Serge G.", "last_name"=>"Lemay", "scopus_author_id"=>"57188691681"}, {"first_name"=>"Helen L.", "last_name"=>"Bridle", "scopus_author_id"=>"23090144300"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84962229542", "scopus"=>"2-s2.0-84962229542", "pmid"=>"26938220", "issn"=>"19326203", "pui"=>"609003220", "isbn"=>"10.1371/journal.pone.0150438", "doi"=>"10.1371/journal.pone.0150438"}, "id"=>"08c2d688-8de5-3ddd-bc9a-d875f8c370d6", "abstract"=>"Many modern filtration technologies are incapable of the complete removal of Cryptosporidium oocysts from drinking-water. Consequently, Cryptosporidium-contaminated drinking-water supplies can severely implicate both water utilities and consumers. Existing methods for the detection of Cryptosporidium in drinking-water do not discern between non-pathogenic and pathogenic species, nor between viable and non-viable oocysts. Using FluidFM, a novel force spectroscopy method employing microchannelled cantilevers for single-cell level manipulation, we assessed the size and deformability properties of two species of Cryptosporidium that pose varying levels of risk to human health. A comparison of such characteristics demonstrated the ability of FluidFM to discern between Cryptosporidium muris and Cryptosporidium parvum with 86% efficiency, whilst using a measurement throughput which exceeded 50 discrete oocysts per hour. In addition, we measured the deformability properties for untreated and temperature-inactivated oocysts of the highly infective, human pathogenic C. parvum to assess whether deformability may be a marker of viability. Our results indicate that untreated and temperature-inactivated C. parvum oocysts had overlapping but significantly different deformability distributions.", "link"=>"http://www.mendeley.com/research/deformability-assessment-waterborne-protozoa-using-microfluidicenabled-force-microscopy-probe", "reader_count"=>14, "reader_count_by_academic_status"=>{"Student > Doctoral Student"=>3, "Researcher"=>1, "Student > Ph. D. Student"=>2, "Other"=>1, "Student > Master"=>5, "Student > Bachelor"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Student > Doctoral Student"=>3, "Researcher"=>1, "Student > Ph. D. Student"=>2, "Other"=>1, "Student > Master"=>5, "Student > Bachelor"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Engineering"=>7, "Agricultural and Biological Sciences"=>2, "Veterinary Science and Veterinary Medicine"=>1, "Physics and Astronomy"=>2, "Chemistry"=>1, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>7}, "Chemistry"=>{"Chemistry"=>1}, "Physics and Astronomy"=>{"Physics and Astronomy"=>2}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "reader_count_by_country"=>{"Switzerland"=>1}, "group_count"=>0}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/4814542"], "description"=>"<p><b>(a)</b> Force-distance curves for five sets of five measurements on a single oocyst. A set of five measurements was taken whilst keeping the oocyst immobilised, and a single colour was assigned to the resulting force-distance curves; after release/re-immobilisation another set of five measurements was taken and a different colour assigned. <b>(b)</b> Effective spring constant values for two oocysts, obtained whilst attaching the oocyst to the cantilever using different suction pressures.</p>", "links"=>[], "tags"=>["oocyst", "species", "deformability properties", "parvum", "Cryptosporidium", "novel force spectroscopy method", "FluidFM"], "article_id"=>3098665, "categories"=>["Space Science", "Physical Sciences not elsewhere classified", "Microbiology", "Cell Biology", "Biotechnology", "Environmental Sciences not elsewhere classified", "Biological Sciences not elsewhere classified", "Hematology"], "users"=>["John S. McGrath", "Jos Quist", "James R. T. Seddon", "Stanley C. S. Lai", "Serge G. Lemay", "Helen L. Bridle"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0150438.g002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Deformability_Assessment_of_Waterborne_Protozoa_Using_a_Microfluidic_Enabled_Force_Microscopy_Probe_Fig_2/3098665", "title"=>"Deformability Assessment of Waterborne Protozoa Using a Microfluidic-Enabled Force Microscopy Probe - Fig 2", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-03-03 08:25:53"}
  • {"files"=>["https://ndownloader.figshare.com/files/4814500", "https://ndownloader.figshare.com/files/4814503", "https://ndownloader.figshare.com/files/4814515", "https://ndownloader.figshare.com/files/4814518", "https://ndownloader.figshare.com/files/4814521", "https://ndownloader.figshare.com/files/4814524"], "description"=>"<div><p>Many modern filtration technologies are incapable of the complete removal of <i>Cryptosporidium</i> oocysts from drinking-water. Consequently, <i>Cryptosporidium</i>-contaminated drinking-water supplies can severely implicate both water utilities and consumers. Existing methods for the detection of <i>Cryptosporidium</i> in drinking-water do not discern between non-pathogenic and pathogenic species, nor between viable and non-viable oocysts. Using FluidFM, a novel force spectroscopy method employing microchannelled cantilevers for single-cell level manipulation, we assessed the size and deformability properties of two species of <i>Cryptosporidium</i> that pose varying levels of risk to human health. A comparison of such characteristics demonstrated the ability of FluidFM to discern between <i>Cryptosporidium muris</i> and <i>Cryptosporidium parvum</i> with 86% efficiency, whilst using a measurement throughput which exceeded 50 discrete oocysts per hour. In addition, we measured the deformability properties for untreated and temperature-inactivated oocysts of the highly infective, human pathogenic <i>C</i>. <i>parvum</i> to assess whether deformability may be a marker of viability. Our results indicate that untreated and temperature-inactivated <i>C</i>. <i>parvum</i> oocysts had overlapping but significantly different deformability distributions.</p></div>", "links"=>[], "tags"=>["oocyst", "species", "deformability properties", "parvum", "Cryptosporidium", "novel force spectroscopy method", "FluidFM"], "article_id"=>3098644, "categories"=>["Space Science", "Physical Sciences not elsewhere classified", "Microbiology", "Cell Biology", "Biotechnology", "Environmental Sciences not elsewhere classified", "Biological Sciences not elsewhere classified", "Hematology"], "users"=>["John S. McGrath", "Jos Quist", "James R. T. Seddon", "Stanley C. S. Lai", "Serge G. Lemay", "Helen L. Bridle"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0150438.s001", "https://dx.doi.org/10.1371/journal.pone.0150438.s002", "https://dx.doi.org/10.1371/journal.pone.0150438.s003", "https://dx.doi.org/10.1371/journal.pone.0150438.s004", "https://dx.doi.org/10.1371/journal.pone.0150438.s005", "https://dx.doi.org/10.1371/journal.pone.0150438.s006"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Deformability_Assessment_of_Waterborne_Protozoa_Using_a_Microfluidic_Enabled_Force_Microscopy_Probe/3098644", "title"=>"Deformability Assessment of Waterborne Protozoa Using a Microfluidic-Enabled Force Microscopy Probe", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2016-03-03 08:25:53"}
  • {"files"=>["https://ndownloader.figshare.com/files/4814530"], "description"=>"<p>Oocyst measurement process <b>(a)</b> Schematic of FluidFM setup. <b>(b)</b> Typical force-distance curve showing zero (no contact), exponential (initial contact), and linear (hard contact) increase of force. <b>(c-e)</b> An oocyst (indicated by dashed blue oval) is selected, measured and released.</p>", "links"=>[], "tags"=>["oocyst", "species", "deformability properties", "parvum", "Cryptosporidium", "novel force spectroscopy method", "FluidFM"], "article_id"=>3098653, "categories"=>["Space Science", "Physical Sciences not elsewhere classified", "Microbiology", "Cell Biology", "Biotechnology", "Environmental Sciences not elsewhere classified", "Biological Sciences not elsewhere classified", "Hematology"], "users"=>["John S. McGrath", "Jos Quist", "James R. T. Seddon", "Stanley C. S. Lai", "Serge G. Lemay", "Helen L. Bridle"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0150438.g001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Deformability_Assessment_of_Waterborne_Protozoa_Using_a_Microfluidic_Enabled_Force_Microscopy_Probe_Fig_1/3098653", "title"=>"Deformability Assessment of Waterborne Protozoa Using a Microfluidic-Enabled Force Microscopy Probe - Fig 1", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-03-03 08:25:53"}
  • {"files"=>["https://ndownloader.figshare.com/files/4814563"], "description"=>"<p>Height <b>(a)</b> and spring constant <b>(b)</b> data for untreated (<i>n</i> = 184), heat-treated (<i>n</i> = 224) and freeze-thawed <i>C</i>. <i>parvum</i> oocysts (<i>n</i> = 131) are represented by boxplots which display medians and quartiles for the respective distributions; the upper and lower error bar caps are indicative of the maximum and minimum recorded values. *** Significantly different from untreated group (<i>p</i> < 0.001). <sup>##</sup> Significantly different from heat-treated group (<i>p</i> < 0.01). The distributions of height <b>(c)</b> and spring constant <b>(d)</b> are presented using histograms.</p>", "links"=>[], "tags"=>["oocyst", "species", "deformability properties", "parvum", "Cryptosporidium", "novel force spectroscopy method", "FluidFM"], "article_id"=>3098686, "categories"=>["Space Science", "Physical Sciences not elsewhere classified", "Microbiology", "Cell Biology", "Biotechnology", "Environmental Sciences not elsewhere classified", "Biological Sciences not elsewhere classified", "Hematology"], "users"=>["John S. McGrath", "Jos Quist", "James R. T. Seddon", "Stanley C. S. Lai", "Serge G. Lemay", "Helen L. Bridle"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0150438.g004", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Height_and_spring_constant_data_for_untreated_heat_treated_and_freeze_thawed_i_C_i_i_parvum_i_oocysts_obtained_using_FluidFM_/3098686", "title"=>"Height and spring constant data for untreated, heat-treated and freeze-thawed <i>C</i>. <i>parvum</i> oocysts obtained using FluidFM.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-03-03 08:25:53"}
  • {"files"=>["https://ndownloader.figshare.com/files/4814551"], "description"=>"<p><b>(a)</b> Height and spring constant data that were obtained for each single assayed oocyst of <i>C</i>. <i>muris</i> (<i>n</i> = 56) and <i>C</i>. <i>parvum</i> (<i>n</i> = 71) are plotted together in a scatterplot and are accompanied by side histograms, which show the distributions of the spring constant <b>(b)</b> and height <b>(c)</b> independently. The human pathogenic <i>C</i>. <i>parvum</i> is indicated by grey and <i>C</i>. <i>muris</i> is indicated by black.</p>", "links"=>[], "tags"=>["oocyst", "species", "deformability properties", "parvum", "Cryptosporidium", "novel force spectroscopy method", "FluidFM"], "article_id"=>3098677, "categories"=>["Space Science", "Physical Sciences not elsewhere classified", "Microbiology", "Cell Biology", "Biotechnology", "Environmental Sciences not elsewhere classified", "Biological Sciences not elsewhere classified", "Hematology"], "users"=>["John S. McGrath", "Jos Quist", "James R. T. Seddon", "Stanley C. S. Lai", "Serge G. Lemay", "Helen L. Bridle"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0150438.g003", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Height_and_deformability_properties_of_untreated_i_C_i_i_muris_i_and_i_C_i_i_parvum_i_oocysts_/3098677", "title"=>"Height and deformability properties of untreated <i>C</i>. <i>muris</i> and <i>C</i>. <i>parvum</i> oocysts.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-03-03 08:25:53"}

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  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"1", "full-text"=>"0", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}

Relative Metric

{"start_date"=>"2016-01-01T00:00:00Z", "end_date"=>"2016-12-31T00:00:00Z", "subject_areas"=>[]}
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