Beneficial Effect of Covalently Grafted α-MSH on Endothelial Release of Inflammatory Mediators for Applications in Implantable Devices
Publication Date
March 03, 2016
Journal
PLOS ONE
Authors
Guillaume Le Saux, Laurent Plawinski, Sylvain Nlate, Jean Ripoche, et al
Volume
11
Issue
3
Pages
e0150706
DOI
https://dx.plos.org/10.1371/journal.pone.0150706
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0150706
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/26939131
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777356
Europe PMC
http://europepmc.org/abstract/MED/26939131
Scopus
84961150296
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Scopus | Further Information

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Figshare

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  • {"files"=>["https://ndownloader.figshare.com/files/4813102"], "description"=>"<p>Experimental atomic composition (%) obtained by XPS.</p>", "links"=>[], "tags"=>["Beneficial Effect", "MSH", "Implantable Devices Intravascular devices", "Inflammatory Mediators", "gold surfaces covalently derivatized", "quantifiable surface density", "Endothelial Release", "glucose monitoring"], "article_id"=>3097540, "categories"=>["Space Science", "Biotechnology", "Chemical Sciences not elsewhere classified", "Immunology", "Biological Sciences not elsewhere classified", "Infectious Diseases"], "users"=>["Guillaume Le Saux", "Laurent Plawinski", "Sylvain Nlate", "Jean Ripoche", "Thierry Buffeteau", "Marie-Christine Durrieu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0150706.t001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Experimental_atomic_composition_obtained_by_XPS_/3097540", "title"=>"Experimental atomic composition (%) obtained by XPS.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2016-03-03 08:17:19"}
  • {"files"=>["https://ndownloader.figshare.com/files/4813030"], "description"=>"<p>C1s and N1s high resolution spectra of the EO<sub>7</sub>-maleimide and EO<sub>7</sub>-MSH surfaces.</p>", "links"=>[], "tags"=>["Beneficial Effect", "MSH", "Implantable Devices Intravascular devices", "Inflammatory Mediators", "gold surfaces covalently derivatized", "quantifiable surface density", "Endothelial Release", "glucose monitoring"], "article_id"=>3097483, "categories"=>["Space Science", "Biotechnology", "Chemical Sciences not elsewhere classified", "Immunology", "Biological Sciences not elsewhere classified", "Infectious Diseases"], "users"=>["Guillaume Le Saux", "Laurent Plawinski", "Sylvain Nlate", "Jean Ripoche", "Thierry Buffeteau", "Marie-Christine Durrieu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0150706.g002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/XPS_analysis_of_maleimide_linker_and_peptide_modified_surfaces_/3097483", "title"=>"XPS analysis of maleimide linker and peptide modified surfaces.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-03-03 08:17:19"}
  • {"files"=>["https://ndownloader.figshare.com/files/4813072"], "description"=>"<p>(A) Epifluorescence images of Endothelial cells that were re-plated onto bare gold, EO<sub>7</sub>-COOH, EO<sub>7</sub>-MSH surfaces and culture dish (control) in culture medium containing 1μg/mL lipopolysaccharide (LPS+) or normal culture medium (LPS-). Cell were stained for actin (green) and nuclei (blue). (B) The fluorescence images were analyzed to determine the average number of adherent cells per mm<sup>2</sup> after cells were adhered for 24h. Error bars represent standard deviations. A Bonferroni test relative to EO<sub>7</sub>-MSH LPS+ vs. other surfaces was performed. Differences were considered significant for p<0.01 and marked with an asterisk. The number of replicates is n = 5.</p>", "links"=>[], "tags"=>["Beneficial Effect", "MSH", "Implantable Devices Intravascular devices", "Inflammatory Mediators", "gold surfaces covalently derivatized", "quantifiable surface density", "Endothelial Release", "glucose monitoring"], "article_id"=>3097519, "categories"=>["Space Science", "Biotechnology", "Chemical Sciences not elsewhere classified", "Immunology", "Biological Sciences not elsewhere classified", "Infectious Diseases"], "users"=>["Guillaume Le Saux", "Laurent Plawinski", "Sylvain Nlate", "Jean Ripoche", "Thierry Buffeteau", "Marie-Christine Durrieu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0150706.g005", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/HUVEC_adhesion_/3097519", "title"=>"HUVEC adhesion.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-03-03 08:17:19"}
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  • {"files"=>["https://ndownloader.figshare.com/files/4813042"], "description"=>"<p>Spectra, expressed in IRRAS units, of (A) EO<sub>7</sub>-MSH surface and (B) compact monolayer of α-MSH.</p>", "links"=>[], "tags"=>["Beneficial Effect", "MSH", "Implantable Devices Intravascular devices", "Inflammatory Mediators", "gold surfaces covalently derivatized", "quantifiable surface density", "Endothelial Release", "glucose monitoring"], "article_id"=>3097495, "categories"=>["Space Science", "Biotechnology", "Chemical Sciences not elsewhere classified", "Immunology", "Biological Sciences not elsewhere classified", "Infectious Diseases"], "users"=>["Guillaume Le Saux", "Laurent Plawinski", "Sylvain Nlate", "Jean Ripoche", "Thierry Buffeteau", "Marie-Christine Durrieu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0150706.g003", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/PM_IRRAS_analysis_/3097495", "title"=>"PM-IRRAS analysis.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-03-03 08:17:19"}
  • {"files"=>["https://ndownloader.figshare.com/files/4813090"], "description"=>"<p>IL-6 production of endothelial cells that were re-plated onto bare gold, EO<sub>7</sub>-COOH, EO<sub>7</sub>-MSH surfaces and culture dish (control) in culture medium containing 1μg/mL lipopolysaccharide (LPS+) or normal culture medium (LPS-). Error bars represent standard deviations. A Bonferroni test relative to EO<sub>7</sub>-MSH LPS+ vs. other LPS+ surfaces was performed. Differences were considered significant for p<0.05 and marked with an asterisk. Another post-hoc test comparing EO7-MSH LPS- to other LPS- surfaces was performed. Differences were considered significant for p<0.05 and marked with a section sign. The number of replicates is n = 5.</p>", "links"=>[], "tags"=>["Beneficial Effect", "MSH", "Implantable Devices Intravascular devices", "Inflammatory Mediators", "gold surfaces covalently derivatized", "quantifiable surface density", "Endothelial Release", "glucose monitoring"], "article_id"=>3097534, "categories"=>["Space Science", "Biotechnology", "Chemical Sciences not elsewhere classified", "Immunology", "Biological Sciences not elsewhere classified", "Infectious Diseases"], "users"=>["Guillaume Le Saux", "Laurent Plawinski", "Sylvain Nlate", "Jean Ripoche", "Thierry Buffeteau", "Marie-Christine Durrieu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0150706.g006", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Surface_bound_MSH_i_versus_i_other_surfaces_/3097534", "title"=>"Surface bound α-MSH <i>versus</i> other surfaces.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-03-03 08:17:19"}
  • {"files"=>["https://ndownloader.figshare.com/files/4813015"], "description"=>"<p>Schematic depiction of bare gold (A) before and (B) after modification with HS-EO<sub>7</sub>-COOH; “EO<sub>7</sub>-COOH” surface. After (C) activation of the carboxyl moieties with EDC/NHS, (D) the surface is functionalized with maleimide; “EO<sub>7</sub>-maleimide” surface. Finally, (E) α-MSH is immobilized on the surface via thiol-maleimide chemistry; “EO<sub>7</sub>-MSH” surface.</p>", "links"=>[], "tags"=>["Beneficial Effect", "MSH", "Implantable Devices Intravascular devices", "Inflammatory Mediators", "gold surfaces covalently derivatized", "quantifiable surface density", "Endothelial Release", "glucose monitoring"], "article_id"=>3097471, "categories"=>["Space Science", "Biotechnology", "Chemical Sciences not elsewhere classified", "Immunology", "Biological Sciences not elsewhere classified", "Infectious Diseases"], "users"=>["Guillaume Le Saux", "Laurent Plawinski", "Sylvain Nlate", "Jean Ripoche", "Thierry Buffeteau", "Marie-Christine Durrieu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0150706.g001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/The_surfaces_used_in_this_study_/3097471", "title"=>"The surfaces used in this study.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2016-03-03 08:17:19"}

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  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
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  • {"unique-ip"=>"7", "full-text"=>"14", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}

Relative Metric

{"start_date"=>"2016-01-01T00:00:00Z", "end_date"=>"2016-12-31T00:00:00Z", "subject_areas"=>[]}
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