Bile Acids and Dysbiosis in Non-Alcoholic Fatty Liver Disease
Publication Date
May 20, 2016
Journal
PLOS ONE
Authors
Marialena Mouzaki, Alice Y. Wang, Robert Bandsma, Elena M. Comelli, et al
Volume
11
Issue
5
Pages
e0151829
DOI
https://dx.plos.org/10.1371/journal.pone.0151829
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0151829
Web of Science
000376291500001
Scopus
84991519034
Mendeley
http://www.mendeley.com/research/bile-acids-dysbiosis-nonalcoholic-fatty-liver-disease-2
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Mendeley | Further Information

{"title"=>"Bile acids and dysbiosis in non-alcoholic fatty liver disease", "type"=>"journal", "authors"=>[{"first_name"=>"Marialena", "last_name"=>"Mouzaki", "scopus_author_id"=>"26534586100"}, {"first_name"=>"Alice Y.", "last_name"=>"Wang", "scopus_author_id"=>"57189304060"}, {"first_name"=>"Robert", "last_name"=>"Bandsma", "scopus_author_id"=>"6603486766"}, {"first_name"=>"Elena M.", "last_name"=>"Comelli", "scopus_author_id"=>"6603054937"}, {"first_name"=>"Bianca M.", "last_name"=>"Arendt", "scopus_author_id"=>"10046095900"}, {"first_name"=>"Ling", "last_name"=>"Zhang", "scopus_author_id"=>"57189302964"}, {"first_name"=>"Scott", "last_name"=>"Fung", "scopus_author_id"=>"7201970083"}, {"first_name"=>"Sandra E.", "last_name"=>"Fischer", "scopus_author_id"=>"55861302800"}, {"first_name"=>"Ian G.", "last_name"=>"McGilvray", "scopus_author_id"=>"35430719100"}, {"first_name"=>"Johane P.", "last_name"=>"Allard", "scopus_author_id"=>"7103067646"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "doi"=>"10.1371/journal.pone.0151829", "sgr"=>"84991519034", "scopus"=>"2-s2.0-84991519034", "isbn"=>"1932-6203", "pmid"=>"27203081", "pui"=>"610470978"}, "id"=>"15343459-e72f-382c-b1fa-313252b8a224", "abstract"=>"BACKGROUND & AIMS: Non-alcoholic fatty liver disease (NAFLD) is characterized by dysbiosis. The bidirectional effects between intestinal microbiota (IM) and bile acids (BA) suggest that dysbiosis may be accompanied by an altered bile acid (BA) homeostasis, which in turn can contribute to the metabolic dysregulation seen in NAFLD. This study sought to examine BA homeostasis in patients with NAFLD and to relate that with IM data. METHODS: This was a prospective, cross-sectional study of adults with biopsy-confirmed NAFLD (non-alcoholic fatty liver: NAFL or non-alcoholic steatohepatitis: NASH) and healthy controls (HC). Clinical and laboratory data, stool samples and 7-day food records were collected. Fecal BA profiles, serum markers of BA synthesis 7-alpha-hydroxy-4-cholesten-3-one (C4) and intestinal BA signalling, as well as IM composition were assessed. RESULTS: 53 subjects were included: 25 HC, 12 NAFL and 16 NASH. Levels of total fecal BA, cholic acid (CA), chenodeoxycholic acid (CDCA) and BA synthesis were higher in patients with NASH compared to HC (p<0.05 for all comparisons). The primary to secondary BA ratio was higher in NASH compared to HC (p = 0.004), but ratio of conjugated to unconjugated BAs was not different between the groups. Bacteroidetes and Clostridium leptum counts were decreased in in a subset of 16 patients with NASH compared to 25 HC, after adjusting for body mass index and weight-adjusted calorie intake (p = 0.028 and p = 0.030, respectively). C. leptum was positively correlated with fecal unconjugated lithocholic acid (LCA) (r = 0.526, p = 0.003) and inversely with unconjugated CA (r = -0.669, p<0.0001) and unconjugated CDCA (r = - 0.630, p<0.0001). FGF19 levels were not different between the groups (p = 0.114). CONCLUSIONS: In adults with NAFLD, dysbiosis is associated with altered BA homeostasis, which renders them at increased risk of hepatic injury.", "link"=>"http://www.mendeley.com/research/bile-acids-dysbiosis-nonalcoholic-fatty-liver-disease-2", "reader_count"=>55, "reader_count_by_academic_status"=>{"Unspecified"=>8, "Professor > Associate Professor"=>1, "Researcher"=>5, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>12, "Student > Postgraduate"=>3, "Other"=>4, "Student > Master"=>6, "Student > Bachelor"=>10, "Lecturer > Senior Lecturer"=>2, "Professor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>8, "Professor > Associate Professor"=>1, "Researcher"=>5, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>12, "Student > Postgraduate"=>3, "Other"=>4, "Student > Master"=>6, "Student > Bachelor"=>10, "Lecturer > Senior Lecturer"=>2, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>11, "Biochemistry, Genetics and Molecular Biology"=>6, "Nursing and Health Professions"=>4, "Medicine and Dentistry"=>15, "Agricultural and Biological Sciences"=>13, "Sports and Recreations"=>1, "Business, Management and Accounting"=>1, "Chemistry"=>1, "Social Sciences"=>1, "Immunology and Microbiology"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>15}, "Chemistry"=>{"Chemistry"=>1}, "Social Sciences"=>{"Social Sciences"=>1}, "Sports and Recreations"=>{"Sports and Recreations"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>13}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>4}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>6}, "Unspecified"=>{"Unspecified"=>11}}, "reader_count_by_country"=>{"United Kingdom"=>2, "France"=>1}, "group_count"=>3}

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