Phase-Sensitive Inversion-Recovery MRI Improves Longitudinal Cortical Lesion Detection in Progressive MS
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{"title"=>"Phase-sensitive inversion-recovery MRI improves longitudinal cortical lesion detection in progressive MS", "type"=>"journal", "authors"=>[{"first_name"=>"Asaff", "last_name"=>"Harel", "scopus_author_id"=>"57061918600"}, {"first_name"=>"Antonia", "last_name"=>"Ceccarelli", "scopus_author_id"=>"14038607500"}, {"first_name"=>"Colleen", "last_name"=>"Farrell", "scopus_author_id"=>"56415884800"}, {"first_name"=>"Michelle", "last_name"=>"Fabian", "scopus_author_id"=>"56586623800"}, {"first_name"=>"Jonathan", "last_name"=>"Howard", "scopus_author_id"=>"55607086400"}, {"first_name"=>"Claire", "last_name"=>"Riley", "scopus_author_id"=>"55069094000"}, {"first_name"=>"Aaron", "last_name"=>"Miller", "scopus_author_id"=>"7406233627"}, {"first_name"=>"Fred", "last_name"=>"Lublin", "scopus_author_id"=>"7006694709"}, {"first_name"=>"Matilde", "last_name"=>"Inglese", "scopus_author_id"=>"7004371136"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "doi"=>"10.1371/journal.pone.0152180", "sgr"=>"84962050595", "scopus"=>"2-s2.0-84962050595", "pmid"=>"27002529", "pui"=>"609296671"}, "id"=>"16492623-1d2a-32eb-a88f-57e12bf8486f", "abstract"=>"Previous studies comparing phase sensitive inversion recovery (PSIR) to double inversion recovery (DIR) have demonstrated that use of PSIR improves cross-sectional in vivo detection of cortical lesions (CL) in multiple sclerosis. We studied the utility of PSIR in detection/characterization of accrual of CL over time in a 1-year longitudinal study in primary progressive multiple sclerosis (PPMS) compared to DIR. PSIR and DIR images were acquired with 3T magnetic resonance imaging (MRI) in 25 patients with PPMS and 19 healthy controls at baseline, and after 1 year in 20 patients with PPMS. CL were classified as intracortical, leucocortical or juxtacortical. Lesion counts and volumes were calculated for both time points from both sequences and compared. Correlations with measures of physical and cognitive disability were determined as well as new CL counts and volumes. Compared to DIR, PSIR led to detection of a higher number of CL involving a larger proportion of patients with PPMS both cross-sectionally (p = 0.006, 88%) and longitudinally (p = 0.007, 95%), and led to the reclassification of a third of CL seen on DIR at each time point. Interestingly, PSIR was more sensitive to new CL accumulation over time compared to DIR. PSIR is a promising technique to monitor cortical damage and disease progression in patients with PPMS over a short-term follow-up.", "link"=>"http://www.mendeley.com/research/phasesensitive-inversionrecovery-mri-improves-longitudinal-cortical-lesion-detection-progressive-ms", "reader_count"=>18, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Researcher"=>3, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>1, "Student > Master"=>4, "Professor"=>3}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Researcher"=>3, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>1, "Student > Master"=>4, "Professor"=>3}, "reader_count_by_subject_area"=>{"Engineering"=>1, "Unspecified"=>2, "Nursing and Health Professions"=>1, "Biochemistry, Genetics and Molecular Biology"=>1, "Medicine and Dentistry"=>8, "Agricultural and Biological Sciences"=>1, "Neuroscience"=>4}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>8}, "Neuroscience"=>{"Neuroscience"=>4}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>2}}, "group_count"=>1}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/4878142"], "description"=>"<p>Baseline and follow-up cortical lesion volumes and counts in patients with primary progressive multiple sclerosis.</p>", "links"=>[], "tags"=>["PPMS", "MRI", "Longitudinal Cortical Lesion Detection", "MS", "inversion recovery", "CL", "detection", "DIR", "PSIR"], "article_id"=>3136888, "categories"=>["Space Science", "Medicine", "Cell Biology", "Physiology", "Chemical Sciences not elsewhere classified", "Biological Sciences not elsewhere classified"], "users"=>["Asaff Harel", "Antonia Ceccarelli", "Colleen Farrell", "Michelle Fabian", "Jonathan Howard", "Claire Riley", "Aaron Miller", "Fred Lublin", "Matilde Inglese"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0152180.t002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Baseline_and_follow_up_cortical_lesion_volumes_and_counts_in_patients_with_primary_progressive_multiple_sclerosis_/3136888", "title"=>"Baseline and follow-up cortical lesion volumes and counts in patients with primary progressive multiple sclerosis.", "pos_in_sequence"=>5, "defined_type"=>3, "published_date"=>"2016-03-22 06:32:08"}
  • {"files"=>["https://ndownloader.figshare.com/files/4878157"], "description"=>"<p>Significant baseline and follow-up correlations between CL counts and volumes and clinical variables (without correction for age and gender).</p>", "links"=>[], "tags"=>["PPMS", "MRI", "Longitudinal Cortical Lesion Detection", "MS", "inversion recovery", "CL", "detection", "DIR", "PSIR"], "article_id"=>3136900, "categories"=>["Space Science", "Medicine", "Cell Biology", "Physiology", "Chemical Sciences not elsewhere classified", "Biological Sciences not elsewhere classified"], "users"=>["Asaff Harel", "Antonia Ceccarelli", "Colleen Farrell", "Michelle Fabian", "Jonathan Howard", "Claire Riley", "Aaron Miller", "Fred Lublin", "Matilde Inglese"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0152180.t003", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Significant_baseline_and_follow_up_correlations_between_CL_counts_and_volumes_and_clinical_variables_without_correction_for_age_and_gender_/3136900", "title"=>"Significant baseline and follow-up correlations between CL counts and volumes and clinical variables (without correction for age and gender).", "pos_in_sequence"=>6, "defined_type"=>3, "published_date"=>"2016-03-22 06:32:08"}
  • {"files"=>["https://ndownloader.figshare.com/files/4878124"], "description"=>"<p>Baseline and follow-up demographics and clinical characteristics of patients with primary progressive multiple sclerosis.</p>", "links"=>[], "tags"=>["PPMS", "MRI", "Longitudinal Cortical Lesion Detection", "MS", "inversion recovery", "CL", "detection", "DIR", "PSIR"], "article_id"=>3136870, "categories"=>["Space Science", "Medicine", "Cell Biology", "Physiology", "Chemical Sciences not elsewhere classified", "Biological Sciences not elsewhere classified"], "users"=>["Asaff Harel", "Antonia Ceccarelli", "Colleen Farrell", "Michelle Fabian", "Jonathan Howard", "Claire Riley", "Aaron Miller", "Fred Lublin", "Matilde Inglese"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0152180.t001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Baseline_and_follow_up_demographics_and_clinical_characteristics_of_patients_with_primary_progressive_multiple_sclerosis_/3136870", "title"=>"Baseline and follow-up demographics and clinical characteristics of patients with primary progressive multiple sclerosis.", "pos_in_sequence"=>4, "defined_type"=>3, "published_date"=>"2016-03-22 06:32:08"}
  • {"files"=>["https://ndownloader.figshare.com/files/4878106"], "description"=>"<p>Baseline and follow-up axial PSIR images of different patients with primary progressive MS demonstrating focal lesions in the cortical grey matter. Intracortical lesion that was too small to be counted at baseline (a, white arrow), but that enlarged and was counted on follow-up scan (b, white arrow). New LC lesion (d, white arrow) noted at follow-up but not at baseline (c).</p>", "links"=>[], "tags"=>["PPMS", "MRI", "Longitudinal Cortical Lesion Detection", "MS", "inversion recovery", "CL", "detection", "DIR", "PSIR"], "article_id"=>3136855, "categories"=>["Space Science", "Medicine", "Cell Biology", "Physiology", "Chemical Sciences not elsewhere classified", "Biological Sciences not elsewhere classified"], "users"=>["Asaff Harel", "Antonia Ceccarelli", "Colleen Farrell", "Michelle Fabian", "Jonathan Howard", "Claire Riley", "Aaron Miller", "Fred Lublin", "Matilde Inglese"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0152180.g003", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Retrospective_analysis_of_new_PSIR_cortical_lesions_/3136855", "title"=>"Retrospective analysis of new PSIR cortical lesions.", "pos_in_sequence"=>3, "defined_type"=>1, "published_date"=>"2016-03-22 06:32:08"}
  • {"files"=>["https://ndownloader.figshare.com/files/4878091"], "description"=>"<p>Baseline and follow up axial DIR (a, b) of the brain of a patient with primary progressive multiple sclerosis (PPMS) demonstrating a new focal lesion in the cortical grey matter (white-arrows) at follow-up. Corresponding baseline and follow-up axial PSIR (c, d) of the same patient with PPMS demonstrating focal lesions in the cortical grey matter (white-arrows) at both baseline and follow-up.</p>", "links"=>[], "tags"=>["PPMS", "MRI", "Longitudinal Cortical Lesion Detection", "MS", "inversion recovery", "CL", "detection", "DIR", "PSIR"], "article_id"=>3136840, "categories"=>["Space Science", "Medicine", "Cell Biology", "Physiology", "Chemical Sciences not elsewhere classified", "Biological Sciences not elsewhere classified"], "users"=>["Asaff Harel", "Antonia Ceccarelli", "Colleen Farrell", "Michelle Fabian", "Jonathan Howard", "Claire Riley", "Aaron Miller", "Fred Lublin", "Matilde Inglese"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0152180.g002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Reclassification_of_new_cortical_lesions_/3136840", "title"=>"Reclassification of new cortical lesions.", "pos_in_sequence"=>2, "defined_type"=>1, "published_date"=>"2016-03-22 06:32:08"}
  • {"files"=>["https://ndownloader.figshare.com/files/4878073"], "description"=>"<p>At baseline (B) no statistically significant differences were detected between DIR and PSIR cortical lesion volumes while differences were found in cortical lesion numbers. PSIR detected a higher number of cortical lesions and leucocortical lesions compared to DIR. Similarly; at follow-up (FU) no statistically significant differences were detected between DIR and PSIR cortical lesion volumes, while differences were found in cortical lesion counts. PSIR detected a higher number of cortical lesions and leucocortical lesions compared to DIR. Furthermore, PSIR at both time points detected juxtacortical lesions.</p>", "links"=>[], "tags"=>["PPMS", "MRI", "Longitudinal Cortical Lesion Detection", "MS", "inversion recovery", "CL", "detection", "DIR", "PSIR"], "article_id"=>3136825, "categories"=>["Space Science", "Medicine", "Cell Biology", "Physiology", "Chemical Sciences not elsewhere classified", "Biological Sciences not elsewhere classified"], "users"=>["Asaff Harel", "Antonia Ceccarelli", "Colleen Farrell", "Michelle Fabian", "Jonathan Howard", "Claire Riley", "Aaron Miller", "Fred Lublin", "Matilde Inglese"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0152180.g001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Baseline_and_follow_up_DIR_and_PSIR_cortical_lesion_volumes_and_numbers_/3136825", "title"=>"Baseline and follow-up DIR and PSIR cortical lesion volumes and numbers.", "pos_in_sequence"=>1, "defined_type"=>1, "published_date"=>"2016-03-22 06:32:08"}

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Relative Metric

{"start_date"=>"2016-01-01T00:00:00Z", "end_date"=>"2016-12-31T00:00:00Z", "subject_areas"=>[]}
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