Systemic and Pulmonary Vascular Remodelling in Chronic Obstructive Pulmonary Disease
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{"title"=>"Systemic and pulmonary vascular remodelling in chronic obstructive pulmonary disease", "type"=>"journal", "authors"=>[{"first_name"=>"Mariana", "last_name"=>"Muñoz-Esquerre", "scopus_author_id"=>"56049777300"}, {"first_name"=>"Marta", "last_name"=>"López-Sánchez", "scopus_author_id"=>"56049347400"}, {"first_name"=>"Ignacio", "last_name"=>"Escobar", "scopus_author_id"=>"14041410200"}, {"first_name"=>"Daniel", "last_name"=>"Huertas", "scopus_author_id"=>"55777337400"}, {"first_name"=>"Rosa", "last_name"=>"Penín", "scopus_author_id"=>"55181392600"}, {"first_name"=>"María", "last_name"=>"Molina-Molina", "scopus_author_id"=>"6507158798"}, {"first_name"=>"Frederic", "last_name"=>"Manresa", "scopus_author_id"=>"7006407624"}, {"first_name"=>"Jordi", "last_name"=>"Dorca", "scopus_author_id"=>"7003615567"}, {"first_name"=>"Salud", "last_name"=>"Santos", "scopus_author_id"=>"57146421200"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84963638740", "doi"=>"10.1371/journal.pone.0152987", "pui"=>"609632873", "issn"=>"19326203", "pmid"=>"27046203", "scopus"=>"2-s2.0-84963638740"}, "id"=>"a58b08db-11c9-3355-91da-c91adc5ce49b", "abstract"=>"BACKGROUND Chronic Obstructive Pulmonary Disease (COPD) is associated with subclinical systemic atherosclerosis and pulmonary vascular remodelling characterized by intimal hyperplasia and luminal narrowing. We aimed to determine differences in the intimal thickening of systemic and pulmonary arteries in COPD subjects and smokers. Secondary aims include comparisons with a non-smokers group; determining the clinical variables associated with systemic and pulmonary intimal thickening, and the correlations between systemic and pulmonary remodelling changes. METHODS All consecutive subjects undergoing lung resection were included and divided into 3 groups: 1) COPD, 2) smokers, and 3) non-smokers. Sections of the 5th intercostal artery and muscular pulmonary arteries were measured by histo-morphometry. Four parameters of intimal thickening were evaluated: 1) percentage of intimal area (%IA), 2) percentage of luminal narrowing, 3) intimal thickness index, and 4) intima-to-media ratio. RESULTS In the adjusted analysis, the systemic arteries of COPD subjects showed greater intimal thickening (%IA) than those of smokers (15.6±1.5% vs. 14.2±1.6%, p = 0.038). In the pulmonary arteries, significant differences were observed for %IA between the 2 groups (37.3±2.2% vs. 29.3±2.3%, p = 0.016). Among clinical factors, metabolic syndrome, gender and COPD status were associated with the systemic intimal thickening, while only COPD status was associated with pulmonary intimal thickening. A correlation between the %IA of the systemic and pulmonary arteries was observed (Spearman's rho = 0.46, p = 0.008). CONCLUSIONS Greater intimal thickening in systemic and pulmonary arteries is observed in COPD patients than in smokers. There is a correlation between systemic and pulmonary vascular remodelling in the overall population.", "link"=>"http://www.mendeley.com/research/systemic-pulmonary-vascular-remodelling-chronic-obstructive-pulmonary-disease-1", "reader_count"=>6, "reader_count_by_academic_status"=>{"Researcher"=>2, "Student > Doctoral Student"=>1, "Student > Master"=>1, "Other"=>1, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_user_role"=>{"Researcher"=>2, "Student > Doctoral Student"=>1, "Student > Master"=>1, "Other"=>1, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>2, "Medicine and Dentistry"=>2, "Agricultural and Biological Sciences"=>1, "Design"=>1}, "reader_count_by_subdiscipline"=>{"Design"=>{"Design"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}}, "reader_count_by_country"=>{"Germany"=>1}, "group_count"=>0}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/4919140"], "description"=>"<p>Images from A to C represent intercostal arteries sections. The intima in <b>A</b> (COPD) is thicker than in the smokers (<b>B</b>) and the non-smokers (<b>C</b>) group. Images from D to F show the muscular pulmonary arteries sections of COPD (<b>D</b>), smokers (<b>E</b>), and non-smokers (<b>F</b>). Vessel remodelling, characterized by thickening of the intima layer, is more evident in the COPD group. Elastin-orcein stain, scale bar = 100μm.</p>", "links"=>[], "tags"=>["COPD status", "COPD subjects", "artery", "remodelling", "IA", "Pulmonary Vascular Remodelling", "Chronic Obstructive Pulmonary Disease Background Chronic Obstructive Pulmonary Disease", "smoker", "correlation"], "article_id"=>3157858, "categories"=>["Medicine", "Cell Biology", "Genetics", "Biotechnology", "Cancer", "Infectious Diseases", "Virology"], "users"=>["Mariana Muñoz-Esquerre", "Marta López-Sánchez", "Ignacio Escobar", "Daniel Huertas", "Rosa Penín", "María Molina-Molina", "Frederic Manresa", "Jordi Dorca", "Salud Santos"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0152987.g003", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Representative_photomicrographs_of_orcein_stained_elastin_fiber_in_cross_sections_of_intercostal_and_muscular_pulmonary_arteries_/3157858", "title"=>"Representative photomicrographs of orcein stained elastin fiber in cross sections of intercostal and muscular pulmonary arteries.", "pos_in_sequence"=>4, "defined_type"=>1, "published_date"=>"2016-04-05 08:32:48"}
  • {"files"=>["https://ndownloader.figshare.com/files/4919119"], "description"=>"<p><b>A-D</b> represents individual data of systemic intimal thickening parameters: intimal area, luminal narrowing, intimal thickness index and intima-to-media ratio, respectively. <b>E-H</b> represents individual data of pulmonary intimal thickening parameters: intimal area, luminal narrowing, intimal thickness index and intima-to-media ratio, respectively. Horizontal bars indicate least squares mean values. P values for the pairwise comparisons using the least significant difference method with general linear model. P1: P-value for unadjusted analysis, P2: P-value for adjusted analysis using as covariables: gender, MetS, cHDL and circulating leukocytes.</p>", "links"=>[], "tags"=>["COPD status", "COPD subjects", "artery", "remodelling", "IA", "Pulmonary Vascular Remodelling", "Chronic Obstructive Pulmonary Disease Background Chronic Obstructive Pulmonary Disease", "smoker", "correlation"], "article_id"=>3157834, "categories"=>["Medicine", "Cell Biology", "Genetics", "Biotechnology", "Cancer", "Infectious Diseases", "Virology"], "users"=>["Mariana Muñoz-Esquerre", "Marta López-Sánchez", "Ignacio Escobar", "Daniel Huertas", "Rosa Penín", "María Molina-Molina", "Frederic Manresa", "Jordi Dorca", "Salud Santos"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0152987.g002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Severity_indices_of_intimal_thickening_in_systemic_and_pulmonary_vessels_by_groups_/3157834", "title"=>"Severity indices of intimal thickening in systemic and pulmonary vessels, by groups.", "pos_in_sequence"=>3, "defined_type"=>1, "published_date"=>"2016-04-05 08:32:48"}
  • {"files"=>["https://ndownloader.figshare.com/files/4919026"], "description"=>"<div><p>Background</p><p>Chronic Obstructive Pulmonary Disease (COPD) is associated with subclinical systemic atherosclerosis and pulmonary vascular remodelling characterized by intimal hyperplasia and luminal narrowing. We aimed to determine differences in the intimal thickening of systemic and pulmonary arteries in COPD subjects and smokers. Secondary aims include comparisons with a non-smokers group; determining the clinical variables associated with systemic and pulmonary intimal thickening, and the correlations between systemic and pulmonary remodelling changes.</p><p>Methods</p><p>All consecutive subjects undergoing lung resection were included and divided into 3 groups: 1) COPD, 2) smokers, and 3) non-smokers. Sections of the 5th intercostal artery and muscular pulmonary arteries were measured by histo-morphometry. Four parameters of intimal thickening were evaluated: 1) percentage of intimal area (%IA), 2) percentage of luminal narrowing, 3) intimal thickness index, and 4) intima-to-media ratio.</p><p>Results</p><p>In the adjusted analysis, the systemic arteries of COPD subjects showed greater intimal thickening (%IA) than those of smokers (15.6±1.5% vs. 14.2±1.6%, p = 0.038). In the pulmonary arteries, significant differences were observed for %IA between the 2 groups (37.3±2.2% vs. 29.3±2.3%, p = 0.016). Among clinical factors, metabolic syndrome, gender and COPD status were associated with the systemic intimal thickening, while only COPD status was associated with pulmonary intimal thickening. A correlation between the %IA of the systemic and pulmonary arteries was observed (Spearman’s rho = 0.46, p = 0.008).</p><p>Conclusions</p><p>Greater intimal thickening in systemic and pulmonary arteries is observed in COPD patients than in smokers. There is a correlation between systemic and pulmonary vascular remodelling in the overall population.</p></div>", "links"=>[], "tags"=>["COPD status", "COPD subjects", "artery", "remodelling", "IA", "Pulmonary Vascular Remodelling", "Chronic Obstructive Pulmonary Disease Background Chronic Obstructive Pulmonary Disease", "smoker", "correlation"], "article_id"=>3157771, "categories"=>["Medicine", "Cell Biology", "Genetics", "Biotechnology", "Cancer", "Infectious Diseases", "Virology"], "users"=>["Mariana Muñoz-Esquerre", "Marta López-Sánchez", "Ignacio Escobar", "Daniel Huertas", "Rosa Penín", "María Molina-Molina", "Frederic Manresa", "Jordi Dorca", "Salud Santos"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0152987", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Systemic_and_Pulmonary_Vascular_Remodelling_in_Chronic_Obstructive_Pulmonary_Disease/3157771", "title"=>"Systemic and Pulmonary Vascular Remodelling in Chronic Obstructive Pulmonary Disease", "pos_in_sequence"=>1, "defined_type"=>6, "published_date"=>"2016-04-05 08:32:48"}
  • {"files"=>["https://ndownloader.figshare.com/files/4919089"], "description"=>"<p><b>A.</b> Fifth intercostal artery showing almost no intimal thickness and muscular media layer. Note also the absence of elastic laminas except for the internal elastic lamina (IEL) and external elastic lamina (EEL). <b>B</b>. Methods used for morphometric analyses as described in the text. A solid white line represents the IEL and the discontinuous black line shows the EEL. The area enclosed by the solid black line is the lumen area (LA), the area enclosed by the solid white line is the combined lumen + intima area (IA) and the area enclosed by the discontinuous black line is the lumen + intima + media area (MA). A double-headed black arrow represents maximal intimal thickness (Max.It). The double-headed white arrow shows the medial thickening (Mt) at maximal intimal thickness. Elastin-orcein stain, scale bar = 100μm.</p>", "links"=>[], "tags"=>["COPD status", "COPD subjects", "artery", "remodelling", "IA", "Pulmonary Vascular Remodelling", "Chronic Obstructive Pulmonary Disease Background Chronic Obstructive Pulmonary Disease", "smoker", "correlation"], "article_id"=>3157804, "categories"=>["Medicine", "Cell Biology", "Genetics", "Biotechnology", "Cancer", "Infectious Diseases", "Virology"], "users"=>["Mariana Muñoz-Esquerre", "Marta López-Sánchez", "Ignacio Escobar", "Daniel Huertas", "Rosa Penín", "María Molina-Molina", "Frederic Manresa", "Jordi Dorca", "Salud Santos"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0152987.g001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Histologic_and_morphometric_analyses_/3157804", "title"=>"Histologic and morphometric analyses.", "pos_in_sequence"=>2, "defined_type"=>1, "published_date"=>"2016-04-05 08:32:48"}
  • {"files"=>["https://ndownloader.figshare.com/files/4919263"], "description"=>"<p>Linear regression analyses for associations between clinical variables and the intimal thickening (%IA) of pulmonary arteries in the overall population.</p>", "links"=>[], "tags"=>["COPD status", "COPD subjects", "artery", "remodelling", "IA", "Pulmonary Vascular Remodelling", "Chronic Obstructive Pulmonary Disease Background Chronic Obstructive Pulmonary Disease", "smoker", "correlation"], "article_id"=>3157969, "categories"=>["Medicine", "Cell Biology", "Genetics", "Biotechnology", "Cancer", "Infectious Diseases", "Virology"], "users"=>["Mariana Muñoz-Esquerre", "Marta López-Sánchez", "Ignacio Escobar", "Daniel Huertas", "Rosa Penín", "María Molina-Molina", "Frederic Manresa", "Jordi Dorca", "Salud Santos"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0152987.t004", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Linear_regression_analyses_for_associations_between_clinical_variables_and_the_intimal_thickening_IA_of_pulmonary_arteries_in_the_overall_population_/3157969", "title"=>"Linear regression analyses for associations between clinical variables and the intimal thickening (%IA) of pulmonary arteries in the overall population.", "pos_in_sequence"=>8, "defined_type"=>3, "published_date"=>"2016-04-05 08:32:48"}
  • {"files"=>["https://ndownloader.figshare.com/files/4919230"], "description"=>"<p>Linear regression analyses for associations between clinical variables and the intimal thickening (%IA) of systemic arteries in the overall population.</p>", "links"=>[], "tags"=>["COPD status", "COPD subjects", "artery", "remodelling", "IA", "Pulmonary Vascular Remodelling", "Chronic Obstructive Pulmonary Disease Background Chronic Obstructive Pulmonary Disease", "smoker", "correlation"], "article_id"=>3157939, "categories"=>["Medicine", "Cell Biology", "Genetics", "Biotechnology", "Cancer", "Infectious Diseases", "Virology"], "users"=>["Mariana Muñoz-Esquerre", "Marta López-Sánchez", "Ignacio Escobar", "Daniel Huertas", "Rosa Penín", "María Molina-Molina", "Frederic Manresa", "Jordi Dorca", "Salud Santos"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0152987.t003", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Linear_regression_analyses_for_associations_between_clinical_variables_and_the_intimal_thickening_IA_of_systemic_arteries_in_the_overall_population_/3157939", "title"=>"Linear regression analyses for associations between clinical variables and the intimal thickening (%IA) of systemic arteries in the overall population.", "pos_in_sequence"=>7, "defined_type"=>3, "published_date"=>"2016-04-05 08:32:48"}
  • {"files"=>["https://ndownloader.figshare.com/files/4919200"], "description"=>"<p>Morphometric measurements and severity indices of intimal thickening in systemic and pulmonary arteries by groups.</p>", "links"=>[], "tags"=>["COPD status", "COPD subjects", "artery", "remodelling", "IA", "Pulmonary Vascular Remodelling", "Chronic Obstructive Pulmonary Disease Background Chronic Obstructive Pulmonary Disease", "smoker", "correlation"], "article_id"=>3157915, "categories"=>["Medicine", "Cell Biology", "Genetics", "Biotechnology", "Cancer", "Infectious Diseases", "Virology"], "users"=>["Mariana Muñoz-Esquerre", "Marta López-Sánchez", "Ignacio Escobar", "Daniel Huertas", "Rosa Penín", "María Molina-Molina", "Frederic Manresa", "Jordi Dorca", "Salud Santos"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0152987.t002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Morphometric_measurements_and_severity_indices_of_intimal_thickening_in_systemic_and_pulmonary_arteries_by_groups_/3157915", "title"=>"Morphometric measurements and severity indices of intimal thickening in systemic and pulmonary arteries by groups.", "pos_in_sequence"=>6, "defined_type"=>3, "published_date"=>"2016-04-05 08:32:48"}
  • {"files"=>["https://ndownloader.figshare.com/files/4919173"], "description"=>"<p>Baseline demographics by groups.</p>", "links"=>[], "tags"=>["COPD status", "COPD subjects", "artery", "remodelling", "IA", "Pulmonary Vascular Remodelling", "Chronic Obstructive Pulmonary Disease Background Chronic Obstructive Pulmonary Disease", "smoker", "correlation"], "article_id"=>3157885, "categories"=>["Medicine", "Cell Biology", "Genetics", "Biotechnology", "Cancer", "Infectious Diseases", "Virology"], "users"=>["Mariana Muñoz-Esquerre", "Marta López-Sánchez", "Ignacio Escobar", "Daniel Huertas", "Rosa Penín", "María Molina-Molina", "Frederic Manresa", "Jordi Dorca", "Salud Santos"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0152987.t001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Baseline_demographics_by_groups_/3157885", "title"=>"Baseline demographics by groups.", "pos_in_sequence"=>5, "defined_type"=>3, "published_date"=>"2016-04-05 08:32:48"}

PMC Usage Stats | Further Information

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  • {"unique-ip"=>"10", "full-text"=>"7", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"13", "full-text"=>"12", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
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Relative Metric

{"start_date"=>"2016-01-01T00:00:00Z", "end_date"=>"2016-12-31T00:00:00Z", "subject_areas"=>[]}
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