Reporting of Positive Results in Randomized Controlled Trials of Mindfulness-Based Mental Health Interventions
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{"title"=>"Reporting of positive results in randomized controlled trials of mindfulness-based mental health interventions", "type"=>"journal", "authors"=>[{"first_name"=>"Stephanie", "last_name"=>"Coronado-Montoya", "scopus_author_id"=>"55636396800"}, {"first_name"=>"Alexander W.", "last_name"=>"Levis", "scopus_author_id"=>"56406152800"}, {"first_name"=>"Linda", "last_name"=>"Kwakkenbos", "scopus_author_id"=>"36163217500"}, {"first_name"=>"Russell J.", "last_name"=>"Steele", "scopus_author_id"=>"14834633400"}, {"first_name"=>"Erick H.", "last_name"=>"Turner", "scopus_author_id"=>"7202447855"}, {"first_name"=>"Brett D.", "last_name"=>"Thombs", "scopus_author_id"=>"8209639200"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84963776240", "pui"=>"609727103", "doi"=>"10.1371/journal.pone.0153220", "isbn"=>"1932-6203", "sgr"=>"84963776240", "pmid"=>"27058355"}, "id"=>"119c4152-2c9e-3ffa-890f-433bf1b18ece", "abstract"=>"BACKGROUND: A large proportion of mindfulness-based therapy trials report statistically significant results, even in the context of very low statistical power. The objective of the present study was to characterize the reporting of \"positive\" results in randomized controlled trials of mindfulness-based therapy. We also assessed mindfulness-based therapy trial registrations for indications of possible reporting bias and reviewed recent systematic reviews and meta-analyses to determine whether reporting biases were identified.\\n\\nMETHODS: CINAHL, Cochrane CENTRAL, EMBASE, ISI, MEDLINE, PsycInfo, and SCOPUS databases were searched for randomized controlled trials of mindfulness-based therapy. The number of positive trials was described and compared to the number that might be expected if mindfulness-based therapy were similarly effective compared to individual therapy for depression. Trial registries were searched for mindfulness-based therapy registrations. CINAHL, Cochrane CENTRAL, EMBASE, ISI, MEDLINE, PsycInfo, and SCOPUS were also searched for mindfulness-based therapy systematic reviews and meta-analyses.\\n\\nRESULTS: 108 (87%) of 124 published trials reported ≥1 positive outcome in the abstract, and 109 (88%) concluded that mindfulness-based therapy was effective, 1.6 times greater than the expected number of positive trials based on effect size d = 0.55 (expected number positive trials = 65.7). Of 21 trial registrations, 13 (62%) remained unpublished 30 months post-trial completion. No trial registrations adequately specified a single primary outcome measure with time of assessment. None of 36 systematic reviews and meta-analyses concluded that effect estimates were overestimated due to reporting biases.\\n\\nCONCLUSIONS: The proportion of mindfulness-based therapy trials with statistically significant results may overstate what would occur in practice.", "link"=>"http://www.mendeley.com/research/reporting-positive-results-randomized-controlled-trials-mindfulnessbased-mental-health-interventions-8", "reader_count"=>157, "reader_count_by_academic_status"=>{"Unspecified"=>4, "Professor > Associate Professor"=>6, "Researcher"=>27, "Student > Doctoral Student"=>20, "Student > Ph. D. Student"=>27, "Student > Postgraduate"=>11, "Other"=>13, "Student > Master"=>21, "Student > Bachelor"=>14, "Lecturer"=>2, "Lecturer > Senior Lecturer"=>3, "Professor"=>9}, "reader_count_by_user_role"=>{"Unspecified"=>4, "Professor > Associate Professor"=>6, "Researcher"=>27, "Student > Doctoral Student"=>20, "Student > Ph. D. Student"=>27, "Student > Postgraduate"=>11, "Other"=>13, "Student > Master"=>21, "Student > Bachelor"=>14, "Lecturer"=>2, "Lecturer > Senior Lecturer"=>3, "Professor"=>9}, "reader_count_by_subject_area"=>{"Unspecified"=>20, "Agricultural and Biological Sciences"=>3, "Arts and Humanities"=>3, "Business, Management and Accounting"=>1, "Economics, Econometrics and Finance"=>2, "Engineering"=>1, "Environmental Science"=>1, "Nursing and Health Professions"=>13, "Biochemistry, Genetics and Molecular Biology"=>1, "Materials Science"=>1, "Mathematics"=>1, "Medicine and Dentistry"=>13, "Neuroscience"=>3, "Psychology"=>81, "Social Sciences"=>13}, "reader_count_by_subdiscipline"=>{"Materials Science"=>{"Materials Science"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>13}, "Social Sciences"=>{"Social Sciences"=>13}, "Psychology"=>{"Psychology"=>81}, "Mathematics"=>{"Mathematics"=>1}, "Unspecified"=>{"Unspecified"=>20}, "Environmental Science"=>{"Environmental Science"=>1}, "Arts and Humanities"=>{"Arts and Humanities"=>3}, "Engineering"=>{"Engineering"=>1}, "Neuroscience"=>{"Neuroscience"=>3}, "Economics, Econometrics and Finance"=>{"Economics, Econometrics and Finance"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>13}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}}, "reader_count_by_country"=>{"Canada"=>1, "Sweden"=>2, "Netherlands"=>1, "Argentina"=>1, "United States"=>4, "Brazil"=>1, "United Kingdom"=>1, "Chile"=>1, "Australia"=>1, "Spain"=>2}, "group_count"=>3}

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Figshare

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  • {"files"=>["https://ndownloader.figshare.com/files/4935037"], "description"=>"<p>Summary of Observed and Expected number of Positive Studies for Key Subgroups with Power Calculation Based on Effect Size d = 0.55<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0153220#t002fn002\" target=\"_blank\"><sup>a</sup></a>.</p>", "links"=>[], "tags"=>["21 trial registrations", "MEDLINE", "therapy", "Randomized Controlled Trials", "EMBASE", "Cochrane CENTRAL", "ISI", "CINAHL", "SCOPUS"], "article_id"=>3169846, "categories"=>["Medicine", "Biotechnology", "Sociology", "Cancer", "Science Policy", "Infectious Diseases"], "users"=>["Stephanie Coronado-Montoya", "Alexander W. Levis", "Linda Kwakkenbos", "Russell J. Steele", "Erick H. Turner", "Brett D. Thombs"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0153220.t002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Summary_of_Observed_and_Expected_number_of_Positive_Studies_for_Key_Subgroups_with_Power_Calculation_Based_on_Effect_Size_d_0_55_sup_a_sup_/3169846", "title"=>"Summary of Observed and Expected number of Positive Studies for Key Subgroups with Power Calculation Based on Effect Size d = 0.55<sup>a</sup>.", "pos_in_sequence"=>6, "defined_type"=>3, "published_date"=>"2016-04-08 07:45:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/4934878", "https://ndownloader.figshare.com/files/4934884", "https://ndownloader.figshare.com/files/4934893", "https://ndownloader.figshare.com/files/4934902", "https://ndownloader.figshare.com/files/4934905", "https://ndownloader.figshare.com/files/4934917", "https://ndownloader.figshare.com/files/4934926"], "description"=>"<div><p>Background</p><p>A large proportion of mindfulness-based therapy trials report statistically significant results, even in the context of very low statistical power. The objective of the present study was to characterize the reporting of “positive” results in randomized controlled trials of mindfulness-based therapy. We also assessed mindfulness-based therapy trial registrations for indications of possible reporting bias and reviewed recent systematic reviews and meta-analyses to determine whether reporting biases were identified.</p><p>Methods</p><p>CINAHL, Cochrane CENTRAL, EMBASE, ISI, MEDLINE, PsycInfo, and SCOPUS databases were searched for randomized controlled trials of mindfulness-based therapy. The number of positive trials was described and compared to the number that might be expected if mindfulness-based therapy were similarly effective compared to individual therapy for depression. Trial registries were searched for mindfulness-based therapy registrations. CINAHL, Cochrane CENTRAL, EMBASE, ISI, MEDLINE, PsycInfo, and SCOPUS were also searched for mindfulness-based therapy systematic reviews and meta-analyses.</p><p>Results</p><p>108 (87%) of 124 published trials reported ≥1 positive outcome in the abstract, and 109 (88%) concluded that mindfulness-based therapy was effective, 1.6 times greater than the expected number of positive trials based on effect size d = 0.55 (expected number positive trials = 65.7). Of 21 trial registrations, 13 (62%) remained unpublished 30 months post-trial completion. No trial registrations adequately specified a single primary outcome measure with time of assessment. None of 36 systematic reviews and meta-analyses concluded that effect estimates were overestimated due to reporting biases.</p><p>Conclusions</p><p>The proportion of mindfulness-based therapy trials with statistically significant results may overstate what would occur in practice.</p></div>", "links"=>[], "tags"=>["21 trial registrations", "MEDLINE", "therapy", "Randomized Controlled Trials", "EMBASE", "Cochrane CENTRAL", "ISI", "CINAHL", "SCOPUS"], "article_id"=>3169756, "categories"=>["Medicine", "Biotechnology", "Sociology", "Cancer", "Science Policy", "Infectious Diseases"], "users"=>["Stephanie Coronado-Montoya", "Alexander W. Levis", "Linda Kwakkenbos", "Russell J. Steele", "Erick H. Turner", "Brett D. Thombs"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0153220.s001", "https://dx.doi.org/10.1371/journal.pone.0153220.s002", "https://dx.doi.org/10.1371/journal.pone.0153220.s003", "https://dx.doi.org/10.1371/journal.pone.0153220.s004", "https://dx.doi.org/10.1371/journal.pone.0153220.s005", "https://dx.doi.org/10.1371/journal.pone.0153220.s006", "https://dx.doi.org/10.1371/journal.pone.0153220.s007"], "stats"=>{"downloads"=>9, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Reporting_of_Positive_Results_in_Randomized_Controlled_Trials_of_Mindfulness_Based_Mental_Health_Interventions/3169756", "title"=>"Reporting of Positive Results in Randomized Controlled Trials of Mindfulness-Based Mental Health Interventions", "pos_in_sequence"=>1, "defined_type"=>4, "published_date"=>"2016-04-08 07:45:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/4935004"], "description"=>"<p>Summary of Observed and Expected number of Positive Studies with Power Calculation Based on Effect Size d = 0.55<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0153220#t001fn002\" target=\"_blank\"><sup>a</sup></a>.</p>", "links"=>[], "tags"=>["21 trial registrations", "MEDLINE", "therapy", "Randomized Controlled Trials", "EMBASE", "Cochrane CENTRAL", "ISI", "CINAHL", "SCOPUS"], "article_id"=>3169837, "categories"=>["Medicine", "Biotechnology", "Sociology", "Cancer", "Science Policy", "Infectious Diseases"], "users"=>["Stephanie Coronado-Montoya", "Alexander W. Levis", "Linda Kwakkenbos", "Russell J. Steele", "Erick H. Turner", "Brett D. Thombs"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0153220.t001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Summary_of_Observed_and_Expected_number_of_Positive_Studies_with_Power_Calculation_Based_on_Effect_Size_d_0_55_sup_a_sup_/3169837", "title"=>"Summary of Observed and Expected number of Positive Studies with Power Calculation Based on Effect Size d = 0.55<sup>a</sup>.", "pos_in_sequence"=>5, "defined_type"=>3, "published_date"=>"2016-04-08 07:45:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/4934986"], "description"=>"<p>PRISMA flow diagram of recent meta-analyses and systematic reviews of mindfulness-based therapy on mental health outcomes, including reasons for and number of excluded reviews.</p>", "links"=>[], "tags"=>["21 trial registrations", "MEDLINE", "therapy", "Randomized Controlled Trials", "EMBASE", "Cochrane CENTRAL", "ISI", "CINAHL", "SCOPUS"], "article_id"=>3169822, "categories"=>["Medicine", "Biotechnology", "Sociology", "Cancer", "Science Policy", "Infectious Diseases"], "users"=>["Stephanie Coronado-Montoya", "Alexander W. Levis", "Linda Kwakkenbos", "Russell J. Steele", "Erick H. Turner", "Brett D. Thombs"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0153220.g003", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/PRISMA_Flow_Diagram_of_Meta_Analysis_and_Systematic_Review_Selection_Process_for_Study_/3169822", "title"=>"PRISMA Flow Diagram of Meta-Analysis and Systematic Review Selection Process for Study.", "pos_in_sequence"=>4, "defined_type"=>1, "published_date"=>"2016-04-08 07:45:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/4934965"], "description"=>"<p>PRISMA flow diagram of trial registrations of completed randomized controlled trials of mindfulness-based therapy on mental health outcomes, including reasons for and number of excluded trial registrations.</p>", "links"=>[], "tags"=>["21 trial registrations", "MEDLINE", "therapy", "Randomized Controlled Trials", "EMBASE", "Cochrane CENTRAL", "ISI", "CINAHL", "SCOPUS"], "article_id"=>3169807, "categories"=>["Medicine", "Biotechnology", "Sociology", "Cancer", "Science Policy", "Infectious Diseases"], "users"=>["Stephanie Coronado-Montoya", "Alexander W. Levis", "Linda Kwakkenbos", "Russell J. Steele", "Erick H. Turner", "Brett D. Thombs"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0153220.g002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/PRISMA_Flow_Diagram_of_Selection_of_Trial_Registrations_of_Completed_Randomized_Controlled_Trials_of_Mindfulness_based_Therapy_/3169807", "title"=>"PRISMA Flow Diagram of Selection of Trial Registrations of Completed Randomized Controlled Trials of Mindfulness-based Therapy.", "pos_in_sequence"=>3, "defined_type"=>1, "published_date"=>"2016-04-08 07:45:59"}

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Relative Metric

{"start_date"=>"2016-01-01T00:00:00Z", "end_date"=>"2016-12-31T00:00:00Z", "subject_areas"=>[]}
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