TGF-β Neutralization Enhances AngII-Induced Aortic Rupture and Aneurysm in Both Thoracic and Abdominal Regions
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{"title"=>"TGF-β neutralization enhances angii-induced aortic rupture and aneurysm in both thoracic and abdominal regions", "type"=>"journal", "authors"=>[{"first_name"=>"Xiaofeng", "last_name"=>"Chen", "scopus_author_id"=>"57005615300"}, {"first_name"=>"Debra L.", "last_name"=>"Rateri", "scopus_author_id"=>"6602349481"}, {"first_name"=>"Deborah A.", "last_name"=>"Howatt", "scopus_author_id"=>"8323169000"}, {"first_name"=>"Anju", "last_name"=>"Balakrishnan", "scopus_author_id"=>"35214522700"}, {"first_name"=>"Jessica J.", "last_name"=>"Moorleghen", "scopus_author_id"=>"13404668100"}, {"first_name"=>"Lisa A.", "last_name"=>"Cassis", "scopus_author_id"=>"7004179074"}, {"first_name"=>"Alan", "last_name"=>"Daugherty", "scopus_author_id"=>"36924112700"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"611092715", "sgr"=>"84977656346", "issn"=>"19326203", "pmid"=>"27104863", "scopus"=>"2-s2.0-84977656346", "doi"=>"10.1371/journal.pone.0153811", "isbn"=>"1932-6203 (Electronic)\r1932-6203 (Linking)"}, "id"=>"3b82bc3d-a6fe-31fa-9baf-9a450a67b1e0", "abstract"=>"AngII and TGF-β interact in development of thoracic and abdominal aortic diseases, although there are many facets of this interaction that have not been clearly defined. The aim of the present study was to determine the effects of TGF-β neutralization on AngII induced-aortic pathologies. Male C57BL/6J mice were administered with either a rabbit or mouse TGF-β neutralizing antibody and then infused with AngII. The rabbit TGF-β antibody modestly reduced serum TGF-β concentrations, with no significant enhancements to AngII-induced aneurysm or rupture. Administration of this rabbit TGF-β antibody in mice led to high serum titers against rabbit IgG that may have attenuated the neutralization. In contrast, a mouse TGF-β antibody (1D11) significantly increased rupture in both the ascending and suprarenal aortic regions, but only at doses that markedly decreased serum TGF-β concentrations. High doses of 1D11 antibody significantly increased AngII-induced ascending and suprarenal aortic dilatation. To determine whether TGF-β neutralization had effects in mice previously infused with AngII, the 1D11 antibody was injected into mice that had been infused with AngII for 28 days and were observed during continued infusion for a further 28 days. Despite near ablations of serum TGF-β concentrations, the mouse TGF-β antibody had no effect on aortic rupture or dimensions in either ascending or suprarenal region. These data provide further evidence that AngII-induced aortic rupture is enhanced greatly by TGF-β neutralization when initiated before pathogenesis.", "link"=>"http://www.mendeley.com/research/tgf%CE%B2-neutralization-enhances-angiiinduced-aortic-rupture-aneurysm-both-thoracic-abdominal-regions", "reader_count"=>20, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Researcher"=>6, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>1, "Other"=>3, "Student > Master"=>1, "Student > Bachelor"=>3, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Researcher"=>6, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>1, "Other"=>3, "Student > Master"=>1, "Student > Bachelor"=>3, "Professor"=>1}, "reader_count_by_subject_area"=>{"Engineering"=>2, "Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>3, "Agricultural and Biological Sciences"=>5, "Medicine and Dentistry"=>9}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>2}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>9}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>5}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Unspecified"=>{"Unspecified"=>1}}, "group_count"=>0}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/5003752"], "description"=>"<p>(A) Serum TGF-β concentration was measured at termination. * denotes P<0.05 by Student’s t-test. (B) Kaplan-Meier curves of survival. (C) Ascending aortic area and (D) suprarenal aortic diameter were measured at termination. For (A), (C) and (D) circles are individual measurements, diamonds are means, and error bars are SEM. (N = 9 for IgG control group and N = 8 for TGF-β Ab group).</p>", "links"=>[], "tags"=>["suprarenal aortic regions", "1 D 11 antibody", "suprarenal aortic dilatation", "TGF", "Abdominal Regions AngII", "Male C 57BL mice", "28 days"], "article_id"=>3197731, "categories"=>["Medicine", "Cell Biology", "Molecular Biology", "Ecology", "Immunology", "Developmental Biology", "Marine Biology", "Cancer", "Hematology", "Infectious Diseases"], "users"=>["Xiaofeng Chen", "Debra L. Rateri", "Deborah A. Howatt", "Anju Balakrishnan", "Jessica J. Moorleghen", "Lisa A. Cassis", "Alan Daugherty"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0153811.g005", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/TGF_neutralization_had_no_effect_on_progression_of_aortic_dilation_and_rupture_/3197731", "title"=>"TGF-β neutralization had no effect on progression of aortic dilation and rupture.", "pos_in_sequence"=>6, "defined_type"=>1, "published_date"=>"2016-04-22 06:19:27"}
  • {"files"=>["https://ndownloader.figshare.com/files/5003686"], "description"=>"<p>(A) Serum TGF-β concentration was measured at termination in mice (N = 5/group) injected with different concentrations of TGF-β antibody. Triangles are means of the groups, and error bars are SEM. (B) Serum TGF-β concentration was measured at termination of study using 5 mg/kg, 3 times/week dose of antibody (Saline + IgG control, n = 5; Saline + TGF-β Ab, n = 5; AngII + IgG control, n = 10; AngII + TGF-β Ab, n = 5). * denotes P<0.05 by two way ANOVA. (C) Kaplan-Meier curves of survival. (D) Incidence of aortic rupture in the ascending and suprarenal aortas of AngII-infused mice injected with TGF-β antibody (n = 20 per group; * = P<0.05; # P<0.01). (E) Ascending aortic area and (F) suprarenal aortic diameter measured at experimental termination. * in denotes P = 0.017 in (E) and P = 0.002 in (F) when comparing TGF- β IgG versus control IgG groups within AngII by two way ANOVA. For (C), (E) and (F): Saline + IgG control, n = 10; Saline + TGF-β Ab, n = 10; AngII + IgG control, n = 19; AngII + TGF-β Ab, n = 8). For (B), (E), (F), circles are individual measurements, diamonds are means, and error bars are SEM.</p>", "links"=>[], "tags"=>["suprarenal aortic regions", "1 D 11 antibody", "suprarenal aortic dilatation", "TGF", "Abdominal Regions AngII", "Male C 57BL mice", "28 days"], "article_id"=>3197668, "categories"=>["Medicine", "Cell Biology", "Molecular Biology", "Ecology", "Immunology", "Developmental Biology", "Marine Biology", "Cancer", "Hematology", "Infectious Diseases"], "users"=>["Xiaofeng Chen", "Debra L. Rateri", "Deborah A. Howatt", "Anju Balakrishnan", "Jessica J. Moorleghen", "Lisa A. Cassis", "Alan Daugherty"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0153811.g002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Mouse_TGF_neutralizing_antibody_promotes_aortic_rupture_and_aneurysm_/3197668", "title"=>"Mouse TGF-β neutralizing antibody promotes aortic rupture and aneurysm.", "pos_in_sequence"=>3, "defined_type"=>1, "published_date"=>"2016-04-22 06:19:27"}
  • {"files"=>["https://ndownloader.figshare.com/files/5003731"], "description"=>"<p>(A) Serum TGF-β concentration was measured at termination (N = 10 per group). * denotes P<0.05 by one way ANOVA. (B) Kaplan-Meier curves of survival. (C) Incidence of aortic rupture in the thoracic and abdominal aorta. (D) Ascending aortic area and (E) suprarenal aortic diameter was measured at termination. For (A), (D) and (E) circles are individual measurements, diamonds are means and error bars are SEM.</p>", "links"=>[], "tags"=>["suprarenal aortic regions", "1 D 11 antibody", "suprarenal aortic dilatation", "TGF", "Abdominal Regions AngII", "Male C 57BL mice", "28 days"], "article_id"=>3197707, "categories"=>["Medicine", "Cell Biology", "Molecular Biology", "Ecology", "Immunology", "Developmental Biology", "Marine Biology", "Cancer", "Hematology", "Infectious Diseases"], "users"=>["Xiaofeng Chen", "Debra L. Rateri", "Deborah A. Howatt", "Anju Balakrishnan", "Jessica J. Moorleghen", "Lisa A. Cassis", "Alan Daugherty"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0153811.g004", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/No_divergent_effect_of_low_dose_versus_high_dose_of_mouse_TGF_neutralizing_antibody_on_aortic_aneurysm_and_rupture_/3197707", "title"=>"No divergent effect of low dose versus high dose of mouse TGF-β neutralizing antibody on aortic aneurysm and rupture.", "pos_in_sequence"=>5, "defined_type"=>1, "published_date"=>"2016-04-22 06:19:27"}
  • {"files"=>["https://ndownloader.figshare.com/files/5003815"], "description"=>"<p>Characteristics of mice after 28 days of AngII infusion.</p>", "links"=>[], "tags"=>["suprarenal aortic regions", "1 D 11 antibody", "suprarenal aortic dilatation", "TGF", "Abdominal Regions AngII", "Male C 57BL mice", "28 days"], "article_id"=>3197776, "categories"=>["Medicine", "Cell Biology", "Molecular Biology", "Ecology", "Immunology", "Developmental Biology", "Marine Biology", "Cancer", "Hematology", "Infectious Diseases"], "users"=>["Xiaofeng Chen", "Debra L. Rateri", "Deborah A. Howatt", "Anju Balakrishnan", "Jessica J. Moorleghen", "Lisa A. Cassis", "Alan Daugherty"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0153811.t002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Characteristics_of_mice_after_28_days_of_AngII_infusion_/3197776", "title"=>"Characteristics of mice after 28 days of AngII infusion.", "pos_in_sequence"=>8, "defined_type"=>3, "published_date"=>"2016-04-22 06:19:27"}
  • {"files"=>["https://ndownloader.figshare.com/files/5003662"], "description"=>"<p>(A) Serum TGF-β concentration was measured at termination; N = 9 in control group and n = 9–10 in TGF- β group; *denotes P<0.05 by Mann-Whitney Rank Sum Test. (B) Kaplan-Meier curves of survival. (C) Ascending aortic area and (D) suprarenal aortic diameter were measured at termination. * denotes P< 0.05 by Student’s t-test. For (A), (C) and (D) circles are individual measurements, diamonds are means, and error bars are SEM,. (E) Serum mouse anti-rabbit titers in plasma were measured at termination in mice injected with Rabbit IgG control, TGF-β antibody or vehicle (No Ab Control). Triangles are means and error bars are SEM. * denotes P<0.05, compared to no antibody control by one way ANOVA on Ranks using Student-Newman-Keuls Method.</p>", "links"=>[], "tags"=>["suprarenal aortic regions", "1 D 11 antibody", "suprarenal aortic dilatation", "TGF", "Abdominal Regions AngII", "Male C 57BL mice", "28 days"], "article_id"=>3197656, "categories"=>["Medicine", "Cell Biology", "Molecular Biology", "Ecology", "Immunology", "Developmental Biology", "Marine Biology", "Cancer", "Hematology", "Infectious Diseases"], "users"=>["Xiaofeng Chen", "Debra L. Rateri", "Deborah A. Howatt", "Anju Balakrishnan", "Jessica J. Moorleghen", "Lisa A. Cassis", "Alan Daugherty"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0153811.g001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Minimal_effects_of_rabbit_TGF_neutralizing_antibody_on_aortic_aneurysm_/3197656", "title"=>"Minimal effects of rabbit TGF-β neutralizing antibody on aortic aneurysm.", "pos_in_sequence"=>2, "defined_type"=>1, "published_date"=>"2016-04-22 06:19:27"}
  • {"files"=>["https://ndownloader.figshare.com/files/5003773"], "description"=>"<p>Characteristics of the mice.</p>", "links"=>[], "tags"=>["suprarenal aortic regions", "1 D 11 antibody", "suprarenal aortic dilatation", "TGF", "Abdominal Regions AngII", "Male C 57BL mice", "28 days"], "article_id"=>3197752, "categories"=>["Medicine", "Cell Biology", "Molecular Biology", "Ecology", "Immunology", "Developmental Biology", "Marine Biology", "Cancer", "Hematology", "Infectious Diseases"], "users"=>["Xiaofeng Chen", "Debra L. Rateri", "Deborah A. Howatt", "Anju Balakrishnan", "Jessica J. Moorleghen", "Lisa A. Cassis", "Alan Daugherty"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0153811.t001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Characteristics_of_the_mice_/3197752", "title"=>"Characteristics of the mice.", "pos_in_sequence"=>7, "defined_type"=>3, "published_date"=>"2016-04-22 06:19:27"}
  • {"files"=>["https://ndownloader.figshare.com/files/5003527", "https://ndownloader.figshare.com/files/5003632", "https://ndownloader.figshare.com/files/5003626", "https://ndownloader.figshare.com/files/5003620", "https://ndownloader.figshare.com/files/5003611", "https://ndownloader.figshare.com/files/5003605", "https://ndownloader.figshare.com/files/5003602", "https://ndownloader.figshare.com/files/5003596", "https://ndownloader.figshare.com/files/5003590", "https://ndownloader.figshare.com/files/5003587", "https://ndownloader.figshare.com/files/5003581", "https://ndownloader.figshare.com/files/5003575", "https://ndownloader.figshare.com/files/5003563", "https://ndownloader.figshare.com/files/5003557", "https://ndownloader.figshare.com/files/5003551", "https://ndownloader.figshare.com/files/5003542", "https://ndownloader.figshare.com/files/5003638"], "description"=>"<div><p>AngII and TGF-β interact in development of thoracic and abdominal aortic diseases, although there are many facets of this interaction that have not been clearly defined. The aim of the present study was to determine the effects of TGF-β neutralization on AngII induced-aortic pathologies. Male C57BL/6J mice were administered with either a rabbit or mouse TGF-β neutralizing antibody and then infused with AngII. The rabbit TGF-β antibody modestly reduced serum TGF-β concentrations, with no significant enhancements to AngII-induced aneurysm or rupture. Administration of this rabbit TGF-β antibody in mice led to high serum titers against rabbit IgG that may have attenuated the neutralization. In contrast, a mouse TGF-β antibody (1D11) significantly increased rupture in both the ascending and suprarenal aortic regions, but only at doses that markedly decreased serum TGF-β concentrations. High doses of 1D11 antibody significantly increased AngII-induced ascending and suprarenal aortic dilatation. To determine whether TGF-β neutralization had effects in mice previously infused with AngII, the 1D11 antibody was injected into mice that had been infused with AngII for 28 days and were observed during continued infusion for a further 28 days. Despite near ablations of serum TGF-β concentrations, the mouse TGF-β antibody had no effect on aortic rupture or dimensions in either ascending or suprarenal region. These data provide further evidence that AngII-induced aortic rupture is enhanced greatly by TGF-β neutralization when initiated before pathogenesis.</p></div>", "links"=>[], "tags"=>["suprarenal aortic regions", "1 D 11 antibody", "suprarenal aortic dilatation", "TGF", "Abdominal Regions AngII", "Male C 57BL mice", "28 days"], "article_id"=>3197593, "categories"=>["Medicine", "Cell Biology", "Molecular Biology", "Ecology", "Immunology", "Developmental Biology", "Marine Biology", "Cancer", "Hematology", "Infectious Diseases"], "users"=>["Xiaofeng Chen", "Debra L. Rateri", "Deborah A. Howatt", "Anju Balakrishnan", "Jessica J. Moorleghen", "Lisa A. Cassis", "Alan Daugherty"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0153811.s001", "https://dx.doi.org/10.1371/journal.pone.0153811.s016", "https://dx.doi.org/10.1371/journal.pone.0153811.s015", "https://dx.doi.org/10.1371/journal.pone.0153811.s014", "https://dx.doi.org/10.1371/journal.pone.0153811.s013", "https://dx.doi.org/10.1371/journal.pone.0153811.s012", "https://dx.doi.org/10.1371/journal.pone.0153811.s011", "https://dx.doi.org/10.1371/journal.pone.0153811.s010", "https://dx.doi.org/10.1371/journal.pone.0153811.s009", "https://dx.doi.org/10.1371/journal.pone.0153811.s008", "https://dx.doi.org/10.1371/journal.pone.0153811.s007", "https://dx.doi.org/10.1371/journal.pone.0153811.s006", "https://dx.doi.org/10.1371/journal.pone.0153811.s005", "https://dx.doi.org/10.1371/journal.pone.0153811.s004", "https://dx.doi.org/10.1371/journal.pone.0153811.s003", "https://dx.doi.org/10.1371/journal.pone.0153811.s002", "https://dx.doi.org/10.1371/journal.pone.0153811.s017"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/TGF_Neutralization_Enhances_AngII_Induced_Aortic_Rupture_and_Aneurysm_in_Both_Thoracic_and_Abdominal_Regions/3197593", "title"=>"TGF-β Neutralization Enhances AngII-Induced Aortic Rupture and Aneurysm in Both Thoracic and Abdominal Regions", "pos_in_sequence"=>1, "defined_type"=>4, "published_date"=>"2016-04-22 06:19:27"}
  • {"files"=>["https://ndownloader.figshare.com/files/5003713"], "description"=>"<p>Aortas of infused mice were ultrasonically scanned at day 4 of infusion. (A) Aortas were imaged in the parasternal long axis view to obtain the measurements of ascending aortas. (B) Two-dimensional images (B mode) of short-axis scans were acquired to determine the maximal diameters of suprarenal aortas. Histobars represent mean ± SEM.</p>", "links"=>[], "tags"=>["suprarenal aortic regions", "1 D 11 antibody", "suprarenal aortic dilatation", "TGF", "Abdominal Regions AngII", "Male C 57BL mice", "28 days"], "article_id"=>3197695, "categories"=>["Medicine", "Cell Biology", "Molecular Biology", "Ecology", "Immunology", "Developmental Biology", "Marine Biology", "Cancer", "Hematology", "Infectious Diseases"], "users"=>["Xiaofeng Chen", "Debra L. Rateri", "Deborah A. Howatt", "Anju Balakrishnan", "Jessica J. Moorleghen", "Lisa A. Cassis", "Alan Daugherty"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0153811.g003", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/TGF_neutralization_5_mg_kg_3_week_had_no_effect_on_early_ascending_and_suprarenal_aortic_dilation_confirmed_by_i_in_vivo_i_ultrasonography_/3197695", "title"=>"TGF-β neutralization (5 mg/kg, 3/week) had no effect on early ascending and suprarenal aortic dilation confirmed by <i>in vivo</i> ultrasonography.", "pos_in_sequence"=>4, "defined_type"=>1, "published_date"=>"2016-04-22 06:19:27"}

PMC Usage Stats | Further Information

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Relative Metric

{"start_date"=>"2016-01-01T00:00:00Z", "end_date"=>"2016-12-31T00:00:00Z", "subject_areas"=>[]}
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