Self-Administered Domiciliary tDCS Treatment for Tinnitus: A Double-Blind Sham-Controlled Study
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Mendeley | Further Information

{"title"=>"Self-Administered Domiciliary tDCS Treatment for Tinnitus: A Double-Blind Sham-Controlled Study", "type"=>"journal", "authors"=>[{"first_name"=>"Petteri", "last_name"=>"Hyvärinen", "scopus_author_id"=>"55915531800"}, {"first_name"=>"Antti", "last_name"=>"Mäkitie", "scopus_author_id"=>"7003415318"}, {"first_name"=>"Antti A.", "last_name"=>"Aarnisalo", "scopus_author_id"=>"6603771218"}], "year"=>2016, "source"=>"PloS one", "identifiers"=>{"isbn"=>"1932-6203 (Electronic)\r1932-6203 (Linking)", "sgr"=>"85015603273", "scopus"=>"2-s2.0-85015603273", "issn"=>"19326203", "pui"=>"614910052", "doi"=>"10.1371/journal.pone.0154286", "pmid"=>"27124116"}, "id"=>"fd05901c-a773-3914-ae9d-c562ad5b85a7", "abstract"=>"Transcranial direct current stimulation (tDCS) has shown potential for providing tinnitus relief, although positive effects have usually been observed only during a short time period after treatment. In recent studies the focus has turned from one-session experiments towards multi-session treatment studies investigating long-term outcomes with double-blinded and sham-controlled study designs. Traditionally, tDCS has been administered in a clinical setting by a healthcare professional but in studies involving multiple treatment sessions, often a trade-off has to be made between sample size and the amount of labor needed to run the trial. Also, as the number of required visits to the clinic increases, the dropout rate is likely to rise proportionally.The aim of the current study was to find out if tDCS treatment for tinnitus could be patient-administered in a domiciliary setting and whether the results would be comparable to those from in-hospital treatment studies. Forty-three patients with chronic (> 6 months) tinnitus were involved in the study, and data on 35 out of these patients were included in final analysis. Patients received 20 minutes of left temporal area anodal (LTA) or bifrontal tDCS stimulation (2 mA) or sham stimulation (0.3 mA) for ten consecutive days. An overall reduction in the main outcome measure, Tinnitus Handicap Inventory (THI), was found (mean change -5.0 points, p < 0.05), but there was no significant difference between active and sham treatment outcomes. Patients found the tDCS treatment easy to administer and they all tolerated it well. In conclusion, self-administered domiciliary tDCS treatment for tinnitus was found safe and feasible and gave outcome results similar to recent randomized controlled long-term treatment trials. The results suggest better overall treatment response-as measured by THI-with domiciliary treatment than with in-hospital treatment, but this advantage is not related to the tDCS variant. The study protocol demonstrated in the current study is not restricted to tinnitus only.", "link"=>"http://www.mendeley.com/research/selfadministered-domiciliary-tdcs-treatment-tinnitus-doubleblind-shamcontrolled-study", "reader_count"=>36, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Librarian"=>2, "Researcher"=>11, "Student > Ph. D. Student"=>6, "Student > Postgraduate"=>1, "Student > Master"=>5, "Other"=>1, "Student > Bachelor"=>4, "Lecturer"=>2, "Professor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Librarian"=>2, "Researcher"=>11, "Student > Ph. D. Student"=>6, "Student > Postgraduate"=>1, "Student > Master"=>5, "Other"=>1, "Student > Bachelor"=>4, "Lecturer"=>2, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Engineering"=>1, "Nursing and Health Professions"=>1, "Medicine and Dentistry"=>11, "Agricultural and Biological Sciences"=>1, "Neuroscience"=>9, "Sports and Recreations"=>1, "Psychology"=>2, "Social Sciences"=>5, "Computer Science"=>2, "Economics, Econometrics and Finance"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>11}, "Neuroscience"=>{"Neuroscience"=>9}, "Social Sciences"=>{"Social Sciences"=>5}, "Sports and Recreations"=>{"Sports and Recreations"=>1}, "Psychology"=>{"Psychology"=>2}, "Economics, Econometrics and Finance"=>{"Economics, Econometrics and Finance"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Computer Science"=>{"Computer Science"=>2}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Unspecified"=>{"Unspecified"=>2}}, "reader_count_by_country"=>{"Canada"=>1, "Finland"=>1, "United Kingdom"=>1}, "group_count"=>6}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/5046322"], "description"=>"<p>Individual mTQ scores pre- and post-treatment shown group-wise.</p>", "links"=>[], "tags"=>["tDCS treatment", "Tinnitus Handicap Inventory", "THI", "sham treatment outcomes", "LTA", "tinnitu", "rise proportionally.The aim"], "article_id"=>3214966, "categories"=>["Medicine", "Pharmacology", "Biotechnology", "Ecology", "Immunology", "Biological Sciences not elsewhere classified", "Science Policy"], "users"=>["Petteri Hyvärinen", "Antti Mäkitie", "Antti A. Aarnisalo"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0154286.g003", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Individual_mTQ_scores_pre-_and_post-treatment_shown_group-wise_/3214966", "title"=>"Individual mTQ scores pre- and post-treatment shown group-wise.", "pos_in_sequence"=>3, "defined_type"=>1, "published_date"=>"2016-04-28 08:43:52"}
  • {"files"=>["https://ndownloader.figshare.com/files/5046283"], "description"=>"<p>Individual THI scores pre- and post-treatment shown group-wise.</p>", "links"=>[], "tags"=>["tDCS treatment", "Tinnitus Handicap Inventory", "THI", "sham treatment outcomes", "LTA", "tinnitu", "rise proportionally.The aim"], "article_id"=>3214936, "categories"=>["Medicine", "Pharmacology", "Biotechnology", "Ecology", "Immunology", "Biological Sciences not elsewhere classified", "Science Policy"], "users"=>["Petteri Hyvärinen", "Antti Mäkitie", "Antti A. Aarnisalo"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0154286.g002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Individual_THI_scores_pre-_and_post-treatment_shown_group-wise_/3214936", "title"=>"Individual THI scores pre- and post-treatment shown group-wise.", "pos_in_sequence"=>2, "defined_type"=>1, "published_date"=>"2016-04-28 08:43:52"}
  • {"files"=>["https://ndownloader.figshare.com/files/5046406"], "description"=>"<p>Group-wise average (± standard deviation) tinnitus scores.</p>", "links"=>[], "tags"=>["tDCS treatment", "Tinnitus Handicap Inventory", "THI", "sham treatment outcomes", "LTA", "tinnitu", "rise proportionally.The aim"], "article_id"=>3215017, "categories"=>["Medicine", "Pharmacology", "Biotechnology", "Ecology", "Immunology", "Biological Sciences not elsewhere classified", "Science Policy"], "users"=>["Petteri Hyvärinen", "Antti Mäkitie", "Antti A. Aarnisalo"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0154286.t002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Group-wise_average_standard_deviation_tinnitus_scores_/3215017", "title"=>"Group-wise average (± standard deviation) tinnitus scores.", "pos_in_sequence"=>6, "defined_type"=>3, "published_date"=>"2016-04-28 08:43:52"}
  • {"files"=>["https://ndownloader.figshare.com/files/5046253"], "description"=>"<p>Figure shows the cap for the bifrontal electrode montage. A different cap was used for the LTA montage.</p>", "links"=>[], "tags"=>["tDCS treatment", "Tinnitus Handicap Inventory", "THI", "sham treatment outcomes", "LTA", "tinnitu", "rise proportionally.The aim"], "article_id"=>3214906, "categories"=>["Medicine", "Pharmacology", "Biotechnology", "Ecology", "Immunology", "Biological Sciences not elsewhere classified", "Science Policy"], "users"=>["Petteri Hyvärinen", "Antti Mäkitie", "Antti A. Aarnisalo"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0154286.g001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Custom-made_tDCS_electrode_cap_with_sewn-on_electrode_positioning_guides_/3214906", "title"=>"Custom-made tDCS electrode cap with sewn-on electrode positioning guides.", "pos_in_sequence"=>1, "defined_type"=>1, "published_date"=>"2016-04-28 08:43:52"}
  • {"files"=>["https://ndownloader.figshare.com/files/5046430"], "description"=>"<p>The Δ-column shows the average intra-individual change from pre- to post-treatment. The F-test compares scores between the LTA, bifrontal and sham groups.</p>", "links"=>[], "tags"=>["tDCS treatment", "Tinnitus Handicap Inventory", "THI", "sham treatment outcomes", "LTA", "tinnitu", "rise proportionally.The aim"], "article_id"=>3215035, "categories"=>["Medicine", "Pharmacology", "Biotechnology", "Ecology", "Immunology", "Biological Sciences not elsewhere classified", "Science Policy"], "users"=>["Petteri Hyvärinen", "Antti Mäkitie", "Antti A. Aarnisalo"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0154286.t003", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Group-wise_average_standard_deviation_depression_BDI_and_anxiety_BAI_scores_/3215035", "title"=>"Group-wise average (± standard deviation) depression (BDI) and anxiety (BAI) scores.", "pos_in_sequence"=>7, "defined_type"=>3, "published_date"=>"2016-04-28 08:43:52"}
  • {"files"=>["https://ndownloader.figshare.com/files/5046379"], "description"=>"<p>T is short for tinnitus. Tinnitus side is marked with the following logic: L: left, R: right, R = L: bilateral with no lateralization, R>L: bilateral lateralizing more to the right side, L>R: bilateral lateralizing more to the left side. Italicized rows represent patients who were excluded from final analysis (see <i><a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0154286#sec007\" target=\"_blank\">Results</a></i> section).</p>", "links"=>[], "tags"=>["tDCS treatment", "Tinnitus Handicap Inventory", "THI", "sham treatment outcomes", "LTA", "tinnitu", "rise proportionally.The aim"], "article_id"=>3215005, "categories"=>["Medicine", "Pharmacology", "Biotechnology", "Ecology", "Immunology", "Biological Sciences not elsewhere classified", "Science Policy"], "users"=>["Petteri Hyvärinen", "Antti Mäkitie", "Antti A. Aarnisalo"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0154286.t001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Patient_characteristics_of_the_participating_subjects_/3215005", "title"=>"Patient characteristics of the participating subjects.", "pos_in_sequence"=>5, "defined_type"=>3, "published_date"=>"2016-04-28 08:43:52"}
  • {"files"=>["https://ndownloader.figshare.com/files/5046358"], "description"=>"<p>Individual VAS scores pre- and post-treatment shown group-wise.</p>", "links"=>[], "tags"=>["tDCS treatment", "Tinnitus Handicap Inventory", "THI", "sham treatment outcomes", "LTA", "tinnitu", "rise proportionally.The aim"], "article_id"=>3214990, "categories"=>["Medicine", "Pharmacology", "Biotechnology", "Ecology", "Immunology", "Biological Sciences not elsewhere classified", "Science Policy"], "users"=>["Petteri Hyvärinen", "Antti Mäkitie", "Antti A. Aarnisalo"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0154286.g004", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Individual_VAS_scores_pre-_and_post-treatment_shown_group-wise_/3214990", "title"=>"Individual VAS scores pre- and post-treatment shown group-wise.", "pos_in_sequence"=>4, "defined_type"=>1, "published_date"=>"2016-04-28 08:43:52"}

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Relative Metric

{"start_date"=>"2016-01-01T00:00:00Z", "end_date"=>"2016-12-31T00:00:00Z", "subject_areas"=>[]}
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