Vitamin D and Risk of Neuroimaging Abnormalities
Publication Date
May 11, 2016
Journal
PLOS ONE
Authors
Thomas J. Littlejohns, Katarina Kos, William E. Henley, Iain A. Lang, et al
Volume
11
Issue
5
Pages
e0154896
DOI
https://dx.plos.org/10.1371/journal.pone.0154896
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0154896
Scopus
84969785482
Mendeley
http://www.mendeley.com/research/vitamin-d-risk-neuroimaging-abnormalities
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Mendeley | Further Information

{"title"=>"Vitamin D and risk of neuroimaging abnormalities", "type"=>"journal", "authors"=>[{"first_name"=>"Thomas J.", "last_name"=>"Littlejohns", "scopus_author_id"=>"55611804500"}, {"first_name"=>"Katarina", "last_name"=>"Kos", "scopus_author_id"=>"9638839100"}, {"first_name"=>"William E.", "last_name"=>"Henley", "scopus_author_id"=>"8860721500"}, {"first_name"=>"Iain A.", "last_name"=>"Lang", "scopus_author_id"=>"15757789400"}, {"first_name"=>"Cedric", "last_name"=>"Annweiler", "scopus_author_id"=>"23059252800"}, {"first_name"=>"Olivier", "last_name"=>"Beauchet", "scopus_author_id"=>"26643319200"}, {"first_name"=>"Paulo H.M.", "last_name"=>"Chaves", "scopus_author_id"=>"7003558869"}, {"first_name"=>"Bryan R.", "last_name"=>"Kestenbaum", "scopus_author_id"=>"35482488400"}, {"first_name"=>"Lewis H.", "last_name"=>"Kuller", "scopus_author_id"=>"7202315657"}, {"first_name"=>"Kenneth M.", "last_name"=>"Langa", "scopus_author_id"=>"35500660200"}, {"first_name"=>"Oscar L.", "last_name"=>"Lopez", "scopus_author_id"=>"35351200500"}, {"first_name"=>"David J.", "last_name"=>"Llewellyn", "scopus_author_id"=>"23477831700"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"27166613", "sgr"=>"84969785482", "doi"=>"10.1371/journal.pone.0154896", "scopus"=>"2-s2.0-84969785482", "pui"=>"610398126", "isbn"=>"2682012000", "issn"=>"19326203"}, "id"=>"e24d54b9-24ca-3a99-a699-b1245c03c81a", "abstract"=>"Vitamin D deficiency has been linked with an increased risk of incident all-cause dementia and Alzheimer's disease. The aim of the current study was to explore the potential mechanisms underlying these associations by determining whether low vitamin D concentrations are associated with the development of incident cerebrovascular and neurodegenerative neuroimaging abnormalities. The population consisted of 1,658 participants aged ≥65 years from the US-based Cardiovascular Health Study who were free from prevalent cardiovascular disease, stroke and dementia at baseline in 1992-93. Serum 25-hydroxyvitamin D (25(OH)D) concentrations were determined by liquid chromatography-tandem mass spectrometry from blood samples collected at baseline. The first MRI scan was conducted between 1991-1994 and the second MRI scan was conducted between 1997-1999. Change in white matter grade, ventricular grade and presence of infarcts between MRI scan one and two were used to define neuroimaging abnormalities. During a mean follow-up of 5.0 years, serum 25(OH)D status was not significantly associated with the development of any neuroimaging abnormalities. Using logistic regression models, the multivariate adjusted odds ratios (95% confidence interval) for worsening white matter grade in participants who were severely 25(OH)D deficient (<25 nmol/L) and deficient (≥25-50 nmol/L) were 0.76 (0.35-1.66) and 1.09 (0.76-1.55) compared to participants with sufficient concentrations (≥50 nmol/L). The multivariate adjusted odds ratios for ventricular grade in participants who were severely 25(OH)D deficient and deficient were 0.49 (0.20-1.19) and 1.12 (0.79-1.59) compared to those sufficient. The multivariate adjusted odds ratios for incident infarcts in participants who were severely 25(OH)D deficient and deficient were 1.95 (0.84-4.54) and 0.73 (0.47-1.95) compared to those sufficient. Overall, serum vitamin D concentrations could not be shown to be associated with the development of cerebrovascular or neurodegenerative neuroimaging abnormalities in Cardiovascular Health Study participants.; ", "link"=>"http://www.mendeley.com/research/vitamin-d-risk-neuroimaging-abnormalities", "reader_count"=>10, "reader_count_by_academic_status"=>{"Researcher"=>3, "Student > Ph. D. Student"=>3, "Student > Bachelor"=>4}, "reader_count_by_user_role"=>{"Researcher"=>3, "Student > Ph. D. Student"=>3, "Student > Bachelor"=>4}, "reader_count_by_subject_area"=>{"Nursing and Health Professions"=>2, "Medicine and Dentistry"=>5, "Neuroscience"=>2, "Unspecified"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>5}, "Neuroscience"=>{"Neuroscience"=>2}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>2}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"Portugal"=>1}, "group_count"=>0}

Scopus | Further Information

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Relative Metric

{"start_date"=>"2016-01-01T00:00:00Z", "end_date"=>"2016-12-31T00:00:00Z", "subject_areas"=>[]}
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