High Persister Mutants in Mycobacterium tuberculosis
Publication Date
May 13, 2016
Journal
PLOS ONE
Authors
Heather L. Torrey, Iris Keren, Laura E. Via, Jong Seok Lee, et al
Volume
11
Issue
5
Pages
e0155127
DOI
https://dx.plos.org/10.1371/journal.pone.0155127
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0155127
Web of Science
000376589400043
Scopus
84969753024
Mendeley
http://www.mendeley.com/research/high-persister-mutants-mycobacterium-tuberculosis
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Mendeley | Further Information

{"title"=>"High persister mutants in mycobacterium tuberculosis", "type"=>"journal", "authors"=>[{"first_name"=>"Heather L.", "last_name"=>"Torrey", "scopus_author_id"=>"56076206900"}, {"first_name"=>"Iris", "last_name"=>"Keren", "scopus_author_id"=>"6508196429"}, {"first_name"=>"Laura E.", "last_name"=>"Via", "scopus_author_id"=>"6701534033"}, {"first_name"=>"Jong Seok", "last_name"=>"Lee", "scopus_author_id"=>"56236245300"}, {"first_name"=>"Kim", "last_name"=>"Lewis", "scopus_author_id"=>"7201597161"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"doi"=>"10.1371/journal.pone.0155127", "sgr"=>"84969753024", "pmid"=>"27176494", "issn"=>"19326203", "scopus"=>"2-s2.0-84969753024", "pui"=>"610397689"}, "id"=>"4035c679-cd2d-3f9d-9695-b1e34a51cd86", "abstract"=>"Mycobacterium tuberculosis forms drug-tolerant persister cells that are the probable cause of its recalcitrance to antibiotic therapy. While genetically identical to the rest of the population, persisters are dormant, which protects them from killing by bactericidal antibiotics. The mechanism of persister formation in M. tuberculosis is not well understood. In this study, we selected for high persister (hip) mutants and characterized them by whole genome sequencing and transcriptome analysis. In parallel, we identified and characterized clinical isolates that naturally produce high levels of persisters. We compared the hip mutants obtained in vitro with clinical isolates to identify candidate persister genes. Genes involved in lipid biosynthesis, carbon metabolism, toxin-antitoxin systems, and transcriptional regulators were among those identified. We also found that clinical hip isolates exhibited greater ex vivo survival than the low persister isolates. Our data suggest that M. tuberculosis persister formation involves multiple pathways, and hip mutants may contribute to the recalcitrance of the infection.", "link"=>"http://www.mendeley.com/research/high-persister-mutants-mycobacterium-tuberculosis", "reader_count"=>86, "reader_count_by_academic_status"=>{"Unspecified"=>3, "Professor > Associate Professor"=>4, "Librarian"=>1, "Researcher"=>15, "Student > Doctoral Student"=>5, "Student > Ph. D. Student"=>29, "Student > Postgraduate"=>1, "Student > Master"=>17, "Student > Bachelor"=>7, "Lecturer"=>1, "Professor"=>3}, "reader_count_by_user_role"=>{"Unspecified"=>3, "Professor > Associate Professor"=>4, "Librarian"=>1, "Researcher"=>15, "Student > Doctoral Student"=>5, "Student > Ph. D. Student"=>29, "Student > Postgraduate"=>1, "Student > Master"=>17, "Student > Bachelor"=>7, "Lecturer"=>1, "Professor"=>3}, "reader_count_by_subject_area"=>{"Engineering"=>1, "Unspecified"=>4, "Environmental Science"=>1, "Biochemistry, Genetics and Molecular Biology"=>23, "Agricultural and Biological Sciences"=>31, "Medicine and Dentistry"=>5, "Pharmacology, Toxicology and Pharmaceutical Science"=>2, "Physics and Astronomy"=>1, "Computer Science"=>1, "Immunology and Microbiology"=>17}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>5}, "Physics and Astronomy"=>{"Physics and Astronomy"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>17}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>31}, "Computer Science"=>{"Computer Science"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>23}, "Unspecified"=>{"Unspecified"=>4}, "Environmental Science"=>{"Environmental Science"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>2}}, "reader_count_by_country"=>{"South Africa"=>1, "Israel"=>1}, "group_count"=>2}

Scopus | Further Information

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