Based on Molecular Profiling of Gene Expression, Palmoplantar Pustulosis and Palmoplantar Pustular Psoriasis Are Highly Related Diseases that Appear to Be Distinct from Psoriasis Vulgaris
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{"title"=>"Based on molecular profiling of gene expression, palmoplantar pustulosis and palmoplantar pustular psoriasis are highly related diseases that appear to be distinct from psoriasis vulgaris", "type"=>"journal", "authors"=>[{"first_name"=>"Robert", "last_name"=>"Bissonnette", "scopus_author_id"=>"7004518096"}, {"first_name"=>"Mayte", "last_name"=>"Suárez-Fariñas", "scopus_author_id"=>"10140242800"}, {"first_name"=>"Xuan", "last_name"=>"Li", "scopus_author_id"=>"57184164500"}, {"first_name"=>"Kathleen M.", "last_name"=>"Bonifacio", "scopus_author_id"=>"56074849400"}, {"first_name"=>"Carrie", "last_name"=>"Brodmerkel", "scopus_author_id"=>"24173173000"}, {"first_name"=>"Judilyn", "last_name"=>"Fuentes-Duculan", "scopus_author_id"=>"14017956800"}, {"first_name"=>"James G.", "last_name"=>"Krueger", "scopus_author_id"=>"7201666842"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"27152848", "doi"=>"10.1371/journal.pone.0155215", "sgr"=>"84968690703", "scopus"=>"2-s2.0-84968690703", "issn"=>"19326203", "pui"=>"610342604"}, "id"=>"08dff84c-5529-3e45-82ed-f80369b774c4", "abstract"=>"INTRODUCTION There is a controversy surrounding the existence of palmoplantar pustulosis (PPP) and palmoplantar pustular psoriasis (PPPP) as separate clinical entities or as variants of the same clinical entity. We used gene expression microarray to compare gene expression in PPP and PPPP. METHODOLOGY/PRINCIPAL FINDINGS Skin biopsies from subjects with PPP (3), PPPP (6), psoriasis vulgaris (10) and acral skin from normal subjects (7) were analyzed using gene expression microarray. Principal component analysis showed that PPP and PPPP were different from psoriasis vulgaris and normal acral skin. However gene expression of PPP and PPPP clustered together and could not be used to differentiate PPP from PPPP. Gene-wise comparison between PPP and PPPP found no gene to be differentially expressed at a false discovery rate lower than 0.05. Surprisingly we found a higher expression of several genes involved in neural pathways (e.g. GPRIN and ADAM23) in PPP/PPPP as compared to psoriasis vulgaris and normal acral skin. Immunohistochemistry confirmed those findings and showed a keratinocyte localization for those proteins. CONCLUSION SIGNIFICANCE PPP and PPPP could not be differentiated using gene expression microarray suggesting that they are not distinct clinical entities. Increased expression of GPRIN1, and ADAM23 in keratinocytes suggests that these proteins could be new therapeutic targets for PPP/PPPP.", "link"=>"http://www.mendeley.com/research/based-molecular-profiling-gene-expression-palmoplantar-pustulosis-palmoplantar-pustular-psoriasis-hi", "reader_count"=>14, "reader_count_by_academic_status"=>{"Librarian"=>1, "Researcher"=>4, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>3, "Student > Master"=>2, "Other"=>2, "Student > Bachelor"=>1}, "reader_count_by_user_role"=>{"Librarian"=>1, "Researcher"=>4, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>3, "Student > Master"=>2, "Other"=>2, "Student > Bachelor"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>1, "Medicine and Dentistry"=>11, "Agricultural and Biological Sciences"=>1, "Energy"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>11}, "Energy"=>{"Energy"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}}, "group_count"=>1}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/5208034"], "description"=>"<p>Gene expression patterns from PPP/PPPP and normal acral skin are strikingly different. For DEG (FDR<0.05, FCH>2), the top 25 up and 25 down-regulated genes in terms of the fold change are presented according to an unsupervised cluster analysis. Yellow-red scale: red represents low gene expression and yellow high gene expression.</p>", "links"=>[], "tags"=>["psoriasis vulgaris", "Palmoplantar Pustular Psoriasis", "ADAM", "gene expression", "Psoriasis Vulgaris Introduction", "acral skin", "Conclusion significance PPP", "PPPP", "gene expression microarray", "GPRIN", "palmoplantar pustular psoriasis", "Principal component analysis"], "article_id"=>3366502, "categories"=>["Medicine", "Cell Biology", "Genetics", "Molecular Biology", "Neuroscience", "Physiology", "Biotechnology", "Evolutionary Biology", "Ecology", "Immunology", "Developmental Biology", "Marine Biology", "Cancer", "Mental Health", "Infectious Diseases", "Virology", "Computational Biology"], "users"=>["Robert Bissonnette", "Mayte Suárez-Fariñas", "Xuan Li", "Kathleen M. Bonifacio", "Carrie Brodmerkel", "Judilyn Fuentes-Duculan", "James G. Krueger"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0155215.g003", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Heat_map_representing_the_expression_profiles_of_the_top_50_differentially_expressed_genes_DEG_of_PPP_PPPP_versus_normal_acral_skin_/3366502", "title"=>"Heat map representing the expression profiles of the top 50 differentially expressed genes (DEG) of PPP/PPPP versus normal acral skin.", "pos_in_sequence"=>3, "defined_type"=>1, "published_date"=>"2016-05-06 05:34:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/5208016"], "description"=>"<p>Gene expression patterns from normal acral and non-acral skin are strikingly different. For DEG (FDR<0.05, FCH>2), the top 25 up and 25 down-regulated genes in terms of the fold change are presented according to an unsupervised cluster analysis. Yellow-red scale: red represents low gene expression and yellow high gene expression.</p>", "links"=>[], "tags"=>["psoriasis vulgaris", "Palmoplantar Pustular Psoriasis", "ADAM", "gene expression", "Psoriasis Vulgaris Introduction", "acral skin", "Conclusion significance PPP", "PPPP", "gene expression microarray", "GPRIN", "palmoplantar pustular psoriasis", "Principal component analysis"], "article_id"=>3366493, "categories"=>["Medicine", "Cell Biology", "Genetics", "Molecular Biology", "Neuroscience", "Physiology", "Biotechnology", "Evolutionary Biology", "Ecology", "Immunology", "Developmental Biology", "Marine Biology", "Cancer", "Mental Health", "Infectious Diseases", "Virology", "Computational Biology"], "users"=>["Robert Bissonnette", "Mayte Suárez-Fariñas", "Xuan Li", "Kathleen M. Bonifacio", "Carrie Brodmerkel", "Judilyn Fuentes-Duculan", "James G. Krueger"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0155215.g002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Heat_map_representing_the_expression_profiles_of_the_top_50_differentially_expressed_genes_DEG_of_normal_acral_versus_normal_non-acral_skin_/3366493", "title"=>"Heat map representing the expression profiles of the top 50 differentially expressed genes (DEG) of normal acral versus normal non-acral skin.", "pos_in_sequence"=>2, "defined_type"=>1, "published_date"=>"2016-05-06 05:34:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/5208046"], "description"=>"<p>There is an increase in expression of ADAM23 and GPRIN1 in PPPP as compared to psoriasis vulgaris and normal acral skin. There is absence of staining with a non-specific isotype antibody (negative control).</p>", "links"=>[], "tags"=>["psoriasis vulgaris", "Palmoplantar Pustular Psoriasis", "ADAM", "gene expression", "Psoriasis Vulgaris Introduction", "acral skin", "Conclusion significance PPP", "PPPP", "gene expression microarray", "GPRIN", "palmoplantar pustular psoriasis", "Principal component analysis"], "article_id"=>3366517, "categories"=>["Medicine", "Cell Biology", "Genetics", "Molecular Biology", "Neuroscience", "Physiology", "Biotechnology", "Evolutionary Biology", "Ecology", "Immunology", "Developmental Biology", "Marine Biology", "Cancer", "Mental Health", "Infectious Diseases", "Virology", "Computational Biology"], "users"=>["Robert Bissonnette", "Mayte Suárez-Fariñas", "Xuan Li", "Kathleen M. Bonifacio", "Carrie Brodmerkel", "Judilyn Fuentes-Duculan", "James G. Krueger"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0155215.g005", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Representative_images_of_ADAM23_and_GPRIN1_localization_in_normal_acral_skin_psoriasis_vulgaris_and_PPPP_as_shown_by_immunohistochemistry_/3366517", "title"=>"Representative images of ADAM23 and GPRIN1 localization in normal acral skin, psoriasis vulgaris and PPPP as shown by immunohistochemistry.", "pos_in_sequence"=>5, "defined_type"=>1, "published_date"=>"2016-05-06 05:34:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/5207995"], "description"=>"<p>(A) Principal component analysis comparing gene expression from PPPP, PPP normal acral skin, normal non-acral skin and non-acral psoriasis vulgaris; PPP and cluster together PPPP. (B) Dendogram with unsupervised clustering of the expression profiles for all samples shows no clear distinction between PPP and PPPP as they appear in the same cluster. (C) There is a strong correlation between comparison of Fold Change (FCH) for PPP vs Normal acral skin and PPPP vs Normal acral skin.</p>", "links"=>[], "tags"=>["psoriasis vulgaris", "Palmoplantar Pustular Psoriasis", "ADAM", "gene expression", "Psoriasis Vulgaris Introduction", "acral skin", "Conclusion significance PPP", "PPPP", "gene expression microarray", "GPRIN", "palmoplantar pustular psoriasis", "Principal component analysis"], "article_id"=>3366478, "categories"=>["Medicine", "Cell Biology", "Genetics", "Molecular Biology", "Neuroscience", "Physiology", "Biotechnology", "Evolutionary Biology", "Ecology", "Immunology", "Developmental Biology", "Marine Biology", "Cancer", "Mental Health", "Infectious Diseases", "Virology", "Computational Biology"], "users"=>["Robert Bissonnette", "Mayte Suárez-Fariñas", "Xuan Li", "Kathleen M. Bonifacio", "Carrie Brodmerkel", "Judilyn Fuentes-Duculan", "James G. Krueger"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0155215.g001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Based_on_Molecular_Profiling_of_Gene_Expression_Palmoplantar_Pustulosis_and_Palmoplantar_Pustular_Psoriasis_Are_Highly_Related_Diseases_that_Appear_to_Be_Distinct_from_Psoriasis_Vulgaris_-_Fig_1/3366478", "title"=>"Based on Molecular Profiling of Gene Expression, Palmoplantar Pustulosis and Palmoplantar Pustular Psoriasis Are Highly Related Diseases that Appear to Be Distinct from Psoriasis Vulgaris - Fig 1", "pos_in_sequence"=>1, "defined_type"=>1, "published_date"=>"2016-05-06 05:34:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/5208040"], "description"=>"<p><b>Heat map representing the expression profiles of the top 75 PPP/PPPP specific (A) and psoriasis specific (B) genes</b>. The psoriasis PPP (P) specific genes are those that are differentially expressed in the PPP/PPPP versus normal acral skin and not differentially expressed in the psoriasis versus normal non-acral skin (FDR<0.05; FCH>2 in both comparisons). Likewise psoriasis specific genes are those that are differentially expressed in psoriasis as compared with normal non-acral skin but are not differentially expressed in the PPP/PPPP versus normal acral skin comparisons. In both cases the top 75 are selected based on the largest differences observed between the log2FCH of the PPP/PPPP vs acral and the psoriasis versus non-acral skin comparison. The expression of several genes, including ADAM23 and GPRIN, is higher in PPP/PPPP (lower left portion of <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0155215#pone.0155215.g005\" target=\"_blank\">Fig 5A</a>) Genes are presented according to an unsupervised cluster analysis. Yellow-red scale: red represents low gene expression and yellow high gene expression.</p>", "links"=>[], "tags"=>["psoriasis vulgaris", "Palmoplantar Pustular Psoriasis", "ADAM", "gene expression", "Psoriasis Vulgaris Introduction", "acral skin", "Conclusion significance PPP", "PPPP", "gene expression microarray", "GPRIN", "palmoplantar pustular psoriasis", "Principal component analysis"], "article_id"=>3366511, "categories"=>["Medicine", "Cell Biology", "Genetics", "Molecular Biology", "Neuroscience", "Physiology", "Biotechnology", "Evolutionary Biology", "Ecology", "Immunology", "Developmental Biology", "Marine Biology", "Cancer", "Mental Health", "Infectious Diseases", "Virology", "Computational Biology"], "users"=>["Robert Bissonnette", "Mayte Suárez-Fariñas", "Xuan Li", "Kathleen M. Bonifacio", "Carrie Brodmerkel", "Judilyn Fuentes-Duculan", "James G. Krueger"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0155215.g004", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Based_on_Molecular_Profiling_of_Gene_Expression_Palmoplantar_Pustulosis_and_Palmoplantar_Pustular_Psoriasis_Are_Highly_Related_Diseases_that_Appear_to_Be_Distinct_from_Psoriasis_Vulgaris_-_Fig_4/3366511", "title"=>"Based on Molecular Profiling of Gene Expression, Palmoplantar Pustulosis and Palmoplantar Pustular Psoriasis Are Highly Related Diseases that Appear to Be Distinct from Psoriasis Vulgaris - Fig 4", "pos_in_sequence"=>4, "defined_type"=>1, "published_date"=>"2016-05-06 05:34:41"}

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Relative Metric

{"start_date"=>"2016-01-01T00:00:00Z", "end_date"=>"2016-12-31T00:00:00Z", "subject_areas"=>[]}
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