The Long Noncoding RNA MALAT-1 Is Highly Expressed in Ovarian Cancer and Induces Cell Growth and Migration
Publication Date
May 26, 2016
Journal
PLOS ONE
Authors
Yanqing Zhou, Xiaying Xu, Huabing Lv, Qirong Wen, et al
Volume
11
Issue
5
Pages
e0155250
DOI
https://dx.plos.org/10.1371/journal.pone.0155250
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0155250
Web of Science
000376882500012
Scopus
84973484066
Mendeley
http://www.mendeley.com/research/long-noncoding-rna-malat1-highly-expressed-ovarian-cancer-induces-cell-growth-migration-1
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Mendeley | Further Information

{"title"=>"The long noncoding RNA MALAT-1 is highly expressed in ovarian cancer and induces cell growth and migration", "type"=>"journal", "authors"=>[{"first_name"=>"Yanqing", "last_name"=>"Zhou", "scopus_author_id"=>"56226101100"}, {"first_name"=>"Xiaying", "last_name"=>"Xu", "scopus_author_id"=>"57001513200"}, {"first_name"=>"Huabing", "last_name"=>"Lv", "scopus_author_id"=>"57189620519"}, {"first_name"=>"Qirong", "last_name"=>"Wen", "scopus_author_id"=>"57002320300"}, {"first_name"=>"Juan", "last_name"=>"Li", "scopus_author_id"=>"56227679200"}, {"first_name"=>"Linyu", "last_name"=>"Tan", "scopus_author_id"=>"56227286600"}, {"first_name"=>"Jianqi", "last_name"=>"Li", "scopus_author_id"=>"56204178000"}, {"first_name"=>"Xiujie", "last_name"=>"Sheng", "scopus_author_id"=>"23101311700"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84973484066", "pmid"=>"27227769", "sgr"=>"84973484066", "pui"=>"610523019", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0155250"}, "id"=>"9580acbb-a321-3153-b26d-abdb4da3110f", "abstract"=>"BACKGROUND: Metastasis associated in lung adenocarcinoma transcript-1 (MALAT-1) is overexpressed during cancer progression and promotes cell migration and invasion in many solid tumors. However, its role in ovarian cancer remains poorly understood.\\n\\nMETHODS: Expressions of MALAT-1 were detected in 37 normal ovarian tissues and 45 ovarian cancer tissues by reverse transcription polymerase chain reaction (RT-PCR). Cell proliferation was observed by CCK-8 assay; Flow cytometry was used to measure cell cycle and apoptosis; Cell migration was detected by transwell migration and invasion assay. In order to evaluate the function of MALAT-1, shRNA combined with DNA microarray and Functional enrichment analysis were performed to determine the transcriptional effects of MALAT-1 silencing in OVCAR3 cells. RNA and protein expression were measured by qRT-PCR and Western blotting, respectively.\\n\\nRESULTS: We found that upregulation of MALAT-1 mRNA in ovarian cancer tissues and enhanced MALAT-1 expression was associated with FIGO stage. Knockdown of MALAT-1 expression in OVCAR3 cells inhibited cell proliferation, migration, and invasion, leading to G0/G1 cell cycle arrest and apoptosis. Overexpressed MALAT-1 expression in SKOV3 cells promoted cell proliferation, migration and invasion. Downregulation of MALAT-1 resulted in significant change of gene expression (at least 2-fold) in 449 genes, which regulate proliferation, cell cycle, and adhesion. As a consequence of MALAT-1 knockdown, MMP13 protein expression decreased, while the expression of MMP19 and ADAMTS1 was increased.\\n\\nCONCLUSIONS: The present study found that MALAT-1 is highly expressed in ovarian tumors. MALAT-1 promotes the growth and migration of ovarian cancer cells, suggesting that MALAT-1 may be an important contributor to ovarian cancer development.", "link"=>"http://www.mendeley.com/research/long-noncoding-rna-malat1-highly-expressed-ovarian-cancer-induces-cell-growth-migration-1", "reader_count"=>13, "reader_count_by_academic_status"=>{"Student > Doctoral Student"=>1, "Researcher"=>2, "Student > Ph. D. Student"=>6, "Student > Postgraduate"=>1, "Student > Master"=>2, "Student > Bachelor"=>1}, "reader_count_by_user_role"=>{"Student > Doctoral Student"=>1, "Researcher"=>2, "Student > Ph. D. Student"=>6, "Student > Postgraduate"=>1, "Student > Master"=>2, "Student > Bachelor"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>7, "Medicine and Dentistry"=>2, "Agricultural and Biological Sciences"=>4}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>4}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>7}}, "group_count"=>1}

Scopus | Further Information

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