Assessment of Free Radical Scavenging Activity of Dimethylglycine Sodium Salt and Its Role in Providing Protection against Lipopolysaccharide-Induced Oxidative Stress in Mice
Publication Date
May 12, 2016
Journal
PLOS ONE
Authors
Kaiwen Bai, Wen Xu, Jingfei Zhang, Tao Kou, et al
Volume
11
Issue
5
Pages
e0155393
DOI
https://dx.plos.org/10.1371/journal.pone.0155393
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0155393
Web of Science
000376588600015
Scopus
84969922366
Mendeley
http://www.mendeley.com/research/assessment-free-radical-scavenging-activity-dimethylglycine-sodium-salt-role-providing-protection-ag
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Mendeley | Further Information

{"title"=>"Assessment of free radical scavenging activity of dimethylglycine sodium salt and its role in providing protection against lipopolysaccharide-induced oxidative stress in mice", "type"=>"journal", "authors"=>[{"first_name"=>"Kaiwen", "last_name"=>"Bai", "scopus_author_id"=>"56600035600"}, {"first_name"=>"Wen", "last_name"=>"Xu", "scopus_author_id"=>"56688815400"}, {"first_name"=>"Jingfei", "last_name"=>"Zhang", "scopus_author_id"=>"8977175700"}, {"first_name"=>"Tao", "last_name"=>"Kou", "scopus_author_id"=>"56033409900"}, {"first_name"=>"Yu", "last_name"=>"Niu", "scopus_author_id"=>"57189391245"}, {"first_name"=>"Xiaoli", "last_name"=>"Wan", "scopus_author_id"=>"57189388187"}, {"first_name"=>"Lili", "last_name"=>"Zhang", "scopus_author_id"=>"55866693900"}, {"first_name"=>"Chao", "last_name"=>"Wang", "scopus_author_id"=>"56707962700"}, {"first_name"=>"Tian", "last_name"=>"Wang", "scopus_author_id"=>"7405564454"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"27171376", "sgr"=>"84969922366", "doi"=>"10.1371/journal.pone.0155393", "scopus"=>"2-s2.0-84969922366", "pui"=>"610397947", "isbn"=>"1932-6203 (Electronic); 1932-6203 (Linking)", "issn"=>"19326203"}, "id"=>"fa3764fc-44ad-3171-9136-c1dbbbbcd071", "abstract"=>"In the present study, the free radical scavenging activities (against 1,1-diphenyl-2-pierylhydrazy (DPPH), 2,2'-Azinobis-(3-ethylbenzthiazoline-6- sulphonate) (ABTS+), Hydrogen peroxide (H2O2)) of dimethylglycine sodium salt (DMG-Na) were measured and compared with those of Trolox (6-hydroxy-2, 5, 7, 8-tetramethylchroman-2-carboxylic acid), a commonly used antioxidant. The radical scavenging activities of DMG-Na were found to be the highest at 40 mg/ml. In Experiment 2, gastric intubation in mice with 12 mg DMG-Na/0.3 ml sterile saline solution significantly increased (P < 0.05) the body weight (BW) (28 d), organ proportion (liver and spleen), and antioxidant capacity in serum and the liver (Superoxide dismutase (SOD), Hydrogen peroxidase (CAT), Glutathione peroxidase (GPx), and Total antioxidant capacity (T-AOC)), and significantly decreased (P < 0.05) the activities of serum Glutamic-pyruvic transaminase (ALT) and Glutamic oxalacetic transaminase (AST) and Methane Dicarboxylic Aldehyde (MDA) contents in the serum and liver. Specifically, the effect of 12 mg DMG-Na/0.3 ml sterile saline solution, which showed the highest antioxidant capacity, was further studied using a mice model. In Experiment 3, the mice CL (CON+ lipopolysaccharide (LPS)) group showed a significant decrease (P < 0.05) in the serum ALT and AST content; hepatic mitochondrial antioxidant capacity (Manganese Superoxide dismutase (MnSOD), Glutathione reductase (GR), GPx, Glutathione (GSH)); MDA and Protein carbonyl (PC) content; Reactive oxygen species (ROS) level, Mitochondrial membrane potential (MMP) level, and expression of liver antioxidant genes (Nuclear factor erythroid 2-related factor 2 (Nrf2), Heme oxygenase 1 (HO-1), Manganese superoxide dismutase (MnSOD), Glutathione peroxidase 1 (Gpx1), Sirtuin 1 (Sirt1)) relative to the mice CS (CON+ sterile saline) group. The DL (DMG+LPS) group showed a significant decrease (P < 0.05) in serum ALT and AST content, ROS level, and expression of liver antioxidant gene MnSOD, Gpx1, Sirt1 and a significant increase (P < 0.05) in the hepatic mitochondrial antioxidant capacity (MnSOD, GSH, GPx, GR) and MMP level relative to the CL group. These results indicate that DMG-Na could protect against the LPS-induced oxidative stress by enhancing the free radical scavenging capacity, and increasing the activity of antioxidant defense system.", "link"=>"http://www.mendeley.com/research/assessment-free-radical-scavenging-activity-dimethylglycine-sodium-salt-role-providing-protection-ag", "reader_count"=>12, "reader_count_by_academic_status"=>{"Unspecified"=>3, "Professor > Associate Professor"=>1, "Researcher"=>3, "Student > Postgraduate"=>1, "Other"=>1, "Student > Master"=>1, "Student > Bachelor"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>3, "Professor > Associate Professor"=>1, "Researcher"=>3, "Student > Postgraduate"=>1, "Other"=>1, "Student > Master"=>1, "Student > Bachelor"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Biochemistry, Genetics and Molecular Biology"=>2, "Agricultural and Biological Sciences"=>6, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>6}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>3}}, "group_count"=>1}

Scopus | Further Information

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  • {"unique-ip"=>"32", "full-text"=>"30", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"32", "full-text"=>"33", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"44", "full-text"=>"40", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
  • {"unique-ip"=>"31", "full-text"=>"30", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}

Relative Metric

{"start_date"=>"2016-01-01T00:00:00Z", "end_date"=>"2016-12-31T00:00:00Z", "subject_areas"=>[]}
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