Evaluation of the Interaction between the Poincianella pyramidalis (Tul.) LP Queiroz Extract and Antimicrobials Using Biological and Analytical Models
Publication Date
May 18, 2016
Journal
PLOS ONE
Authors
Thiago P. Chaves, Felipe Hugo A. Fernandes, Cleildo P. Santana, Jocimar S. Santos, et al
Volume
11
Issue
5
Pages
e0155532
DOI
https://dx.plos.org/10.1371/journal.pone.0155532
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0155532
Scopus
84971414807
Mendeley
http://www.mendeley.com/research/evaluation-interaction-between-poincianella-pyramidalis-tul-lp-queiroz-extract-antimicrobials-using
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Mendeley | Further Information

{"title"=>"Evaluation of the interaction between the Poincianella pyramidalis (Tul.) LP Queiroz extract and antimicrobials using biological and analytical models", "type"=>"journal", "authors"=>[{"first_name"=>"Thiago P.", "last_name"=>"Chaves", "scopus_author_id"=>"55307783200"}, {"first_name"=>"Felipe Hugo A.", "last_name"=>"Fernandes", "scopus_author_id"=>"55512698700"}, {"first_name"=>"Cleildo P.", "last_name"=>"Santana", "scopus_author_id"=>"55511980600"}, {"first_name"=>"Jocimar S.", "last_name"=>"Santos", "scopus_author_id"=>"57189493763"}, {"first_name"=>"Francinalva D.", "last_name"=>"Medeiros", "scopus_author_id"=>"57189494819"}, {"first_name"=>"Délcio C.", "last_name"=>"Felismino", "scopus_author_id"=>"55963211600"}, {"first_name"=>"Vanda L.", "last_name"=>"Santos", "scopus_author_id"=>"55308843200"}, {"first_name"=>"Raïssa Mayer R.", "last_name"=>"Catão", "scopus_author_id"=>"6506611023"}, {"first_name"=>"Henrique Douglas M.", "last_name"=>"Coutinho", "scopus_author_id"=>"35236795400"}, {"first_name"=>"Ana Cláudia D.", "last_name"=>"Medeiros", "scopus_author_id"=>"7005447976"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84971414807", "sgr"=>"84971414807", "pui"=>"610472262", "doi"=>"10.1371/journal.pone.0155532"}, "id"=>"36901c48-0dde-3092-9cc8-c03477fd0ef8", "abstract"=>"© 2016 Chaves et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Poincianella pyramidalis (Tul.) LP Queiroz (Fabaceae) is an endemic tree of northeastern Brazil, occurring mainly in the Caatinga. Its medicinal use is widespread and is an important therapeutic option against diarrhea, dysentery, and respiratory and urinary infections, among other diseases. In this study we determined the chemical marker and evaluated the interaction between P. pyramidalis extract and a commercial antimicrobial through the use of biological and analytical models. To obtain the extract, an ethanol-water mixture (50:50 v/v) was used as solvent. It was nebulized in a spray dryer using colloidal silicon dioxide as a drying adjuvant. The extract (ENPp) was subjected to HPLC analysis to verify the presence of certain secondary metabolites. The Minimum Inhibitory Concentration (MIC) of the extract against Gram-negative bacteria was determined by broth microdilution and the MIC of synthetic antimicrobial drugs in the presence and absence of the extract. The antioxidant activity of ENPp was evaluated by the DPPH method. The compatibility between the antimicrobial and the extract was evaluated by thermal analysis (TG/DTA). The acute toxicity of the extract was evaluated in vivo in rodents. The results indicate significant additive action of the extract on synthetic antibiotics, considerable antioxidant activity and absence of toxicity. This extract shows high potential for the development of formulations for antimicrobial therapy when used with a vegetable-active ingredient.", "link"=>"http://www.mendeley.com/research/evaluation-interaction-between-poincianella-pyramidalis-tul-lp-queiroz-extract-antimicrobials-using", "reader_count"=>11, "reader_count_by_academic_status"=>{"Researcher"=>3, "Student > Ph. D. Student"=>2, "Other"=>1, "Student > Master"=>5}, "reader_count_by_user_role"=>{"Researcher"=>3, "Student > Ph. D. Student"=>2, "Other"=>1, "Student > Master"=>5}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>1, "Materials Science"=>2, "Agricultural and Biological Sciences"=>2, "Chemistry"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>5}, "reader_count_by_subdiscipline"=>{"Materials Science"=>{"Materials Science"=>2}, "Chemistry"=>{"Chemistry"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>5}}, "group_count"=>0}

Scopus | Further Information

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https://api.elsevier.com/content/search/index:SCOPUS?query=DOI(10.1371%2Fjournal.pone.0155532)
Trace

/app/models/concerns/networkable.rb:21:in `get_result'
/app/models/source.rb:165:in `get_data'
/app/models/retrieval_status.rb:47:in `perform_get_data'
/app/jobs/source_job.rb:52:in `block (2 levels) in perform'
/app/jobs/source_job.rb:51:in `block in perform'
/app/jobs/source_job.rb:35:in `each'
/app/jobs/source_job.rb:35:in `perform'