Prescribing of Antidiabetic Medicines before, during and after Pregnancy: A Study in Seven European Regions
Publication Date
May 18, 2016
Journal
PLOS ONE
Authors
Rachel A. Charlton, Kari Klungsøyr, Amanda J. Neville, Sue Jordan, et al
Volume
11
Issue
5
Pages
e0155737
DOI
https://dx.plos.org/10.1371/journal.pone.0155737
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0155737
Scopus
84971477048
Mendeley
http://www.mendeley.com/research/prescribing-antidiabetic-medicines-before-during-after-pregnancy-study-seven-european-regions-3
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Mendeley | Further Information

{"title"=>"Prescribing of antidiabetic medicines before, during and after pregnancy: A study in seven European regions", "type"=>"journal", "authors"=>[{"first_name"=>"Rachel A.", "last_name"=>"Charlton", "scopus_author_id"=>"23099230100"}, {"first_name"=>"Kari", "last_name"=>"Klungsøyr", "scopus_author_id"=>"54787707700"}, {"first_name"=>"Amanda J.", "last_name"=>"Neville", "scopus_author_id"=>"7103205645"}, {"first_name"=>"Sue", "last_name"=>"Jordan", "scopus_author_id"=>"36484678300"}, {"first_name"=>"Anna", "last_name"=>"Pierini", "scopus_author_id"=>"7006392523"}, {"first_name"=>"Lolkje T.W.", "last_name"=>"De Jong-Van Den Berg", "scopus_author_id"=>"7102440197"}, {"first_name"=>"H. Jens", "last_name"=>"Bos", "scopus_author_id"=>"37761069000"}, {"first_name"=>"Aurora", "last_name"=>"Puccini", "scopus_author_id"=>"37361461600"}, {"first_name"=>"Anders", "last_name"=>"Engeland", "scopus_author_id"=>"7003614018"}, {"first_name"=>"Rosa", "last_name"=>"Gini", "scopus_author_id"=>"18433997300"}, {"first_name"=>"Gareth", "last_name"=>"Davies", "scopus_author_id"=>"7402854905"}, {"first_name"=>"Daniel", "last_name"=>"Thayer", "scopus_author_id"=>"56011372000"}, {"first_name"=>"Anne V.", "last_name"=>"Hansen", "scopus_author_id"=>"55855433200"}, {"first_name"=>"Margery", "last_name"=>"Morgan", "scopus_author_id"=>"55245450200"}, {"first_name"=>"Hao", "last_name"=>"Wang", "scopus_author_id"=>"56227652800"}, {"first_name"=>"Anita", "last_name"=>"McGrogan", "scopus_author_id"=>"25422461400"}, {"first_name"=>"Anne Marie Nybo", "last_name"=>"Andersen", "scopus_author_id"=>"55042290500"}, {"first_name"=>"Helen", "last_name"=>"Dolk", "scopus_author_id"=>"55522682000"}, {"first_name"=>"Ester", "last_name"=>"Garne", "scopus_author_id"=>"7003909015"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84971477048", "pmid"=>"27192491", "pui"=>"610472356", "scopus"=>"2-s2.0-84971477048", "doi"=>"10.1371/journal.pone.0155737", "issn"=>"19326203"}, "id"=>"b2b5f546-1688-3a03-a64c-15158a1d5dd1", "abstract"=>"AIM: To explore antidiabetic medicine prescribing to women before, during and after pregnancy in different regions of Europe. METHODS: A common protocol was implemented across seven databases in Denmark, Norway, The Netherlands, Italy (Emilia Romagna/Tuscany), Wales and the rest of the UK. Women with a pregnancy starting and ending between 2004 and 2010, (Denmark, 2004-2009; Norway, 2005-2010; Emilia Romagna, 2008-2010), which ended in a live or stillbirth, were identified. Prescriptions for antidiabetic medicines issued (UK) or dispensed (non-UK) during pregnancy and/or the year before or year after pregnancy were identified. Prescribing patterns were compared across databases and over calendar time. RESULTS: 1,082,673 live/stillbirths were identified. Pregestational insulin prescribing during the year before pregnancy ranged from 0.27% (CI95 0.25-0.30) in Tuscany to 0.45% (CI95 0.43-0.47) in Norway, and increased between 2004 and 2009 in all countries. During pregnancy, insulin prescribing peaked during the third trimester and increased over time; third trimester prescribing was highest in Tuscany (2.2%) and lowest in Denmark (0.5%). Of those prescribed an insulin during pregnancy, between 50.5% in Denmark and 88.8% in the Netherlands received an insulin analogue alone or in combination with human insulin, this proportion increasing over time. Oral products were mainly metformin and prescribing was highest in the 3 months before pregnancy. Metformin use during pregnancy increased in some countries. CONCLUSION: Pregestational diabetes is increasing in many areas of Europe. There is considerable variation between and within countries in the choice of medication for treating pregestational diabetes in pregnancy, including choice of insulin analogues and oral antidiabetics, and very large variation in the treatment of gestational diabetes despite international guidelines.", "link"=>"http://www.mendeley.com/research/prescribing-antidiabetic-medicines-before-during-after-pregnancy-study-seven-european-regions-3", "reader_count"=>9, "reader_count_by_academic_status"=>{"Researcher"=>2, "Student > Postgraduate"=>2, "Student > Bachelor"=>3, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_user_role"=>{"Researcher"=>2, "Student > Postgraduate"=>2, "Student > Bachelor"=>3, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Medicine and Dentistry"=>4, "Pharmacology, Toxicology and Pharmaceutical Science"=>3, "Psychology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>4}, "Psychology"=>{"Psychology"=>1}, "Unspecified"=>{"Unspecified"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>3}}, "reader_count_by_country"=>{"Netherlands"=>1}, "group_count"=>0}

Scopus | Further Information

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