Impact of Wild Loci on the Allergenic Potential of Cultivated Tomato Fruits
Publication Date
May 16, 2016
Journal
PLOS ONE
Authors
Alessandra Ghiani, Nunzio D’agostino, Sandra Citterio, Assunta Raiola, et al
Volume
11
Issue
5
Pages
e0155803
DOI
https://dx.plos.org/10.1371/journal.pone.0155803
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0155803
Scopus
84969848955
Mendeley
http://www.mendeley.com/research/impact-wild-loci-allergenic-potential-cultivated-tomato-fruits
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Mendeley | Further Information

{"title"=>"Impact of Wild Loci on the Allergenic Potential of Cultivated Tomato Fruits", "type"=>"journal", "authors"=>[{"first_name"=>"Alessandra", "last_name"=>"Ghiani", "scopus_author_id"=>"6602380013"}, {"first_name"=>"Nunzio", "last_name"=>"D'Agostino", "scopus_author_id"=>"57192701625"}, {"first_name"=>"Sandra", "last_name"=>"Citterio", "scopus_author_id"=>"7004015314"}, {"first_name"=>"Assunta", "last_name"=>"Raiola", "scopus_author_id"=>"37051446200"}, {"first_name"=>"Riccardo", "last_name"=>"Asero", "scopus_author_id"=>"7005364192"}, {"first_name"=>"Amalia", "last_name"=>"Barone", "scopus_author_id"=>"16071412900"}, {"first_name"=>"Maria Manuela", "last_name"=>"Rigano", "scopus_author_id"=>"6603034553"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"610397906", "scopus"=>"2-s2.0-84969848955", "doi"=>"10.1371/journal.pone.0155803", "sgr"=>"84969848955", "issn"=>"19326203"}, "id"=>"64309f76-3882-3f47-8d10-3527fc020f79", "abstract"=>"© 2016 Ghiani et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Tomato (Solanum lycopersicum) is one of the most extensively consumed vegetables but, unfortunately, it is also able to induce allergic reactions. In the past, it has been shown that the choice of tomato cultivar significantly influenced the allergic reaction of tomato allergic subjects. In this study we investigated the allergenic potential of the cultivated tomato line M82 and of two selected lines carrying small chromosome regions from the wild species Solanum pennellii (i.e. IL7-3 and IL12-4). We evaluated the positive interactions of IgEs of allergic subjects in order to investigate the different allergenic potential of the lines under investigation. We used proteomic analyses in order to identify putative tomato allergens. In addition, bioinformatic and transcriptomic approaches were applied in order to analyse the structure and the expression profiles of the identified allergen-encoding genes. These analyses demonstrated that fruits harvested from the two selected introgression lines harbour a different allergenic potential as those from the cultivated genotype M82. The different allergenicity found within the three lines was mostly due to differences in the IgE recognition of a polygalacturonase enzyme (46 kDa), one of the major tomato allergens, and of a pectin methylesterase (34 kDa); both the proteins were more immunoreactive in IL7-3 compared to IL12-4 and M82. The observed differences in the allergenic potential were mostly due to line-dependent translational control or post-translational modifications of the allergens. We demonstrated, for the first time, that the introgression from a wild species (S. pennellii) in the genomic background of a cultivated tomato line influences the allergenic properties of the fruits. Our findings could support the isolation of favorable wild loci promoting low allergenic potential in tomato.", "link"=>"http://www.mendeley.com/research/impact-wild-loci-allergenic-potential-cultivated-tomato-fruits", "reader_count"=>6, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Researcher"=>2, "Student > Bachelor"=>1, "Student > Master"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Researcher"=>2, "Student > Bachelor"=>1, "Student > Master"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Environmental Science"=>1, "Nursing and Health Professions"=>1, "Agricultural and Biological Sciences"=>3}, "reader_count_by_subdiscipline"=>{"Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Unspecified"=>{"Unspecified"=>1}, "Environmental Science"=>{"Environmental Science"=>1}}, "reader_count_by_country"=>{"Hungary"=>1}, "group_count"=>0}

Scopus | Further Information

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