Animal Models of Rheumatoid Arthritis (I): Pristane-Induced Arthritis in the Rat
Publication Date
May 26, 2016
Journal
PLOS ONE
Authors
Jonatan Tuncel, Sabrina Haag, Markus H. Hoffmann, Anthony C. Y. Yau, et al
Volume
11
Issue
5
Pages
e0155936
DOI
https://dx.plos.org/10.1371/journal.pone.0155936
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0155936
Web of Science
000376882500043
Scopus
84973469340
Mendeley
http://www.mendeley.com/research/animal-models-rheumatoid-arthritis-i-pristaneinduced-arthritis-rat
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Mendeley | Further Information

{"title"=>"Animal models of rheumatoid arthritis (I): Pristane-induced arthritis in the rat", "type"=>"journal", "authors"=>[{"first_name"=>"Jonatan", "last_name"=>"Tuncel", "scopus_author_id"=>"11440272600"}, {"first_name"=>"Sabrina", "last_name"=>"Haag", "scopus_author_id"=>"36096647100"}, {"first_name"=>"Markus H.", "last_name"=>"Hoffmann", "scopus_author_id"=>"57192114601"}, {"first_name"=>"Anthony C.Y.", "last_name"=>"Yau", "scopus_author_id"=>"55325389300"}, {"first_name"=>"Malin", "last_name"=>"Hultqvist", "scopus_author_id"=>"8662948600"}, {"first_name"=>"Peter", "last_name"=>"Olofsson", "scopus_author_id"=>"7006629340"}, {"first_name"=>"Johan", "last_name"=>"B�cklund", "scopus_author_id"=>"57201179707"}, {"first_name"=>"Kutty Selva", "last_name"=>"Nandakumar", "scopus_author_id"=>"35564710600"}, {"first_name"=>"Daniela", "last_name"=>"Weidner", "scopus_author_id"=>"35312919800"}, {"first_name"=>"Anita", "last_name"=>"Fischer", "scopus_author_id"=>"56585211500"}, {"first_name"=>"Anna", "last_name"=>"Leichsenring", "scopus_author_id"=>"24741180900"}, {"first_name"=>"Franziska", "last_name"=>"Lange", "scopus_author_id"=>"8924626200"}, {"first_name"=>"Claus", "last_name"=>"Haase", "scopus_author_id"=>"57143969800"}, {"first_name"=>"Shemin", "last_name"=>"Lu", "scopus_author_id"=>"7404227747"}, {"first_name"=>"Percio S.", "last_name"=>"Gulko", "scopus_author_id"=>"6603093891"}, {"first_name"=>"G�nter", "last_name"=>"Steiner", "scopus_author_id"=>"56903702400"}, {"first_name"=>"Rikard", "last_name"=>"Holmdahl", "scopus_author_id"=>"7103259084"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "sgr"=>"84973469340", "doi"=>"10.1371/journal.pone.0155936", "scopus"=>"2-s2.0-84973469340", "pmid"=>"27227821", "pui"=>"610522983"}, "id"=>"ecd4576f-deae-3a31-bc9b-ef5307e0b8ba", "abstract"=>"BACKGROUND: To facilitate the development of therapies for rheumatoid arthritis (RA), the Innovative Medicines Initiative BTCure has combined the experience from several laboratories worldwide to establish a series of protocols for different animal models of arthritis that reflect the pathogenesis of RA. Here, we describe chronic pristane-induced arthritis (PIA) model in DA rats, and provide detailed instructions to set up and evaluate the model and for reporting data. METHODS: We optimized dose of pristane and immunization procedures and determined the effect of age, gender, and housing conditions. We further assessed cage-effects, reproducibility, and frequency of chronic arthritis, disease markers, and efficacy of standard and novel therapies. RESULTS: Out of 271 rats, 99.6% developed arthritis after pristane-administration. Mean values for day of onset, day of maximum arthritis severity and maximum clinical scores were 11.8+/-2.0 days, 20.3+/-5.1 days and 34.2+/-11 points on a 60-point scale, respectively. The mean frequency of chronic arthritis was 86% but approached 100% in long-term experiments over 110 days. Pristane was arthritogenic even at 5 microliters dose but needed to be administrated intradermally to induce robust disease with minimal variation. The development of arthritis was age-dependent but independent of gender and whether the rats were housed in conventional or barrier facilities. PIA correlated well with weight loss and acute phase reactants, and was ameliorated by etanercept, dexamethasone, cyclosporine A and fingolimod treatment. CONCLUSIONS: PIA has high incidence and excellent reproducibility. The chronic relapsing-remitting disease and limited systemic manifestations make it more suitable than adjuvant arthritis for long-term studies of joint-inflammation and screening and validation of new therapeutics.", "link"=>"http://www.mendeley.com/research/animal-models-rheumatoid-arthritis-i-pristaneinduced-arthritis-rat", "reader_count"=>31, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>4, "Researcher"=>4, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>9, "Student > Master"=>5, "Other"=>2, "Student > Bachelor"=>2, "Professor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>4, "Researcher"=>4, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>9, "Student > Master"=>5, "Other"=>2, "Student > Bachelor"=>2, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>4, "Medicine and Dentistry"=>13, "Agricultural and Biological Sciences"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>4, "Physics and Astronomy"=>1, "Chemistry"=>2, "Immunology and Microbiology"=>5}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>13}, "Chemistry"=>{"Chemistry"=>2}, "Physics and Astronomy"=>{"Physics and Astronomy"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>5}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>4}, "Unspecified"=>{"Unspecified"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>4}}, "reader_count_by_country"=>{"Peru"=>1}, "group_count"=>0}

Scopus | Further Information

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