East Coast Fever Caused by Theileria parva Is Characterized by Macrophage Activation Associated with Vasculitis and Respiratory Failure
Publication Date
May 19, 2016
Journal
PLOS ONE
Authors
Lindsay M. Fry, David A. Schneider, Charles W. Frevert, Danielle D. Nelson, et al
Volume
11
Issue
5
Pages
e0156004
DOI
https://dx.plos.org/10.1371/journal.pone.0156004
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0156004
Web of Science
000376291100148
Scopus
84970963449
Mendeley
http://www.mendeley.com/research/east-coast-fever-caused-theileria-parva-characterized-macrophage-activation-associated-vasculitis-re
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Mendeley | Further Information

{"title"=>"East coast fever caused by Theileria parva is characterized by macrophage activation associated with vasculitis and respiratory failure", "type"=>"journal", "authors"=>[{"first_name"=>"Lindsay M.", "last_name"=>"Fry", "scopus_author_id"=>"56806463200"}, {"first_name"=>"David A.", "last_name"=>"Schneider", "scopus_author_id"=>"55153675000"}, {"first_name"=>"Charles W.", "last_name"=>"Frevert", "scopus_author_id"=>"7004592935"}, {"first_name"=>"Danielle D.", "last_name"=>"Nelson", "scopus_author_id"=>"18936383200"}, {"first_name"=>"W. Ivan", "last_name"=>"Morrison", "scopus_author_id"=>"7202131346"}, {"first_name"=>"Donald P.", "last_name"=>"Knowles", "scopus_author_id"=>"7202057474"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84970963449", "pmid"=>"27195791", "pui"=>"610471076", "isbn"=>"1932-6203 (Electronic) 1932-6203 (Linking)", "scopus"=>"2-s2.0-84970963449", "doi"=>"10.1371/journal.pone.0156004", "issn"=>"19326203"}, "id"=>"6bde8c3a-2ff7-3ccc-bc84-1050310d4cf7", "abstract"=>"Respiratory failure and death in East Coast Fever (ECF), a clinical syndrome of African cattle caused by the apicomplexan parasite Theileria parva, has historically been attributed to pulmonary infiltration by infected lymphocytes. However, immunohistochemical staining of tissue from T. parva infected cattle revealed large numbers of CD3- and CD20-negative intralesional mononuclear cells. Due to this finding, we hypothesized that macrophages play an important role in Theileria parva disease pathogenesis. Data presented here demonstrates that terminal ECF in both Holstein and Boran cattle is largely due to multisystemic histiocytic responses and resultant tissue damage. Furthermore, the combination of these histologic changes with the clinical findings, including lymphadenopathy, prolonged pyrexia, multi-lineage leukopenia, and thrombocytopenia is consistent with macrophage activation syndrome. All animals that succumbed to infection exhibited lymphohistiocytic vasculitis of small to medium caliber blood and lymphatic vessels. In pulmonary, lymphoid, splenic and hepatic tissues from Holstein cattle, the majority of intralesional macrophages were positive for CD163, and often expressed large amounts of IL-17. These data define a terminal ECF pathogenesis in which parasite-driven lymphoproliferation leads to secondary systemic macrophage activation syndrome, mononuclear vasculitis, pulmonary edema, respiratory failure and death. The accompanying macrophage phenotype defined by CD163 and IL-17 is presented in the context of this pathogenesis.", "link"=>"http://www.mendeley.com/research/east-coast-fever-caused-theileria-parva-characterized-macrophage-activation-associated-vasculitis-re", "reader_count"=>24, "reader_count_by_academic_status"=>{"Researcher"=>7, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>2, "Student > Master"=>7, "Student > Bachelor"=>3, "Lecturer > Senior Lecturer"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Researcher"=>7, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>2, "Student > Master"=>7, "Student > Bachelor"=>3, "Lecturer > Senior Lecturer"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>4, "Agricultural and Biological Sciences"=>6, "Medicine and Dentistry"=>5, "Veterinary Science and Veterinary Medicine"=>7, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Computer Science"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>5}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>6}, "Computer Science"=>{"Computer Science"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>4}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>7}}, "reader_count_by_country"=>{"Japan"=>1}, "group_count"=>0}

Scopus | Further Information

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