Mouse and Human CD1d-Self-Lipid Complexes Are Recognized Differently by Murine Invariant Natural Killer T Cell Receptors
Publication Date
May 23, 2016
Journal
PLOS ONE
Authors
Tingxi Guo, Kenji Chamoto, Munehide Nakatsugawa, Toshiki Ochi, et al
Volume
11
Issue
5
Pages
e0156114
DOI
https://dx.plos.org/10.1371/journal.pone.0156114
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0156114
Web of Science
000376880200056
Scopus
84971277781
Mendeley
http://www.mendeley.com/research/mouse-human-cd1dselflipid-complexes-recognized-differently-murine-invariant-natural-killer-t-cell-re
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Mendeley | Further Information

{"title"=>"Mouse and human CD1d-self-lipid complexes are recognized differently by murine invariant natural killer T cell receptors", "type"=>"journal", "authors"=>[{"first_name"=>"Tingxi", "last_name"=>"Guo", "scopus_author_id"=>"56574654900"}, {"first_name"=>"Kenji", "last_name"=>"Chamoto", "scopus_author_id"=>"6602781210"}, {"first_name"=>"Munehide", "last_name"=>"Nakatsugawa", "scopus_author_id"=>"8569813100"}, {"first_name"=>"Toshiki", "last_name"=>"Ochi", "scopus_author_id"=>"24335514100"}, {"first_name"=>"Yuki", "last_name"=>"Yamashita", "scopus_author_id"=>"54796249000"}, {"first_name"=>"Mark", "last_name"=>"Anczurowski", "scopus_author_id"=>"57188760513"}, {"first_name"=>"Marcus O.", "last_name"=>"Butler", "scopus_author_id"=>"7402210938"}, {"first_name"=>"Naoto", "last_name"=>"Hirano", "scopus_author_id"=>"7101604261"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84971277781", "doi"=>"10.1371/journal.pone.0156114", "pui"=>"610471052", "sgr"=>"84971277781"}, "id"=>"5cb468df-4a76-30e6-903d-7a41f8e4db29", "abstract"=>"© 2016 Guo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Invariant natural killer T (iNKT) cells recognize self-lipids presented by CD1d through characteristic TCRs, which mainly consist of the invariant Vα14-Jα18 TCRα chain and Vβ8.2, 7 or 2 TCRβ chains with hypervariable CDR3β sequences in mice. The iNKT cell-CD1d axis is conserved between humans and mice, and human CD1d reactivity of murine iNKT cells have been described. However, the detailed differences between the recognition of human and mouse CD1d bound to various self-lipids by mouse iNKT TCRs are largely unknown. In this study, we generated a de novo murine iNKT TCR repertoire with a wider range of autoreactivity compared with that of naturally occurring peripheral iNKT TCRs. Vβ8.2 mouse iNKT TCRs capable of recognizing the human CD1d-self-lipid tetramer were identified, although such clones were not detectable in the Vβ7 or Vβ2 iNKT TCR repertoire. In line with previously reports, clonotypic Vβ8.2 iNKT TCRs with unique CDR3β loops did not discriminate among lipids presented by mouse CD1d. Unexpectedly, however, these iNKT TCRs showed greater ligand selectivity toward human CD1d presenting the same lipids. Our findings demonstrated that the recognition of mouse and human CD1d-self-lipid complexes by murine iNKT TCRs is not conserved, thereby further elucidating the differences between cognate and cross-species reactivity of self-antigens by mouse iNKT TCRs.", "link"=>"http://www.mendeley.com/research/mouse-human-cd1dselflipid-complexes-recognized-differently-murine-invariant-natural-killer-t-cell-re", "reader_count"=>8, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Student > Ph. D. Student"=>2, "Other"=>1, "Student > Bachelor"=>4}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Student > Ph. D. Student"=>2, "Other"=>1, "Student > Bachelor"=>4}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>2, "Agricultural and Biological Sciences"=>2, "Medicine and Dentistry"=>1, "Immunology and Microbiology"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"United States"=>1}, "group_count"=>2}

Scopus | Further Information

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