Vitamin D Status Does Not Affect Disability Progression of Patients with Multiple Sclerosis over Three Year Follow-Up
Publication Date
June 08, 2016
Journal
PLOS ONE
Authors
Anne Hilde Muris, Joost Smolders, Linda Rolf, Lieke J. J. Klinkenberg, et al
Volume
11
Issue
6
Pages
e0156122
DOI
https://dx.plos.org/10.1371/journal.pone.0156122
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0156122
Web of Science
000377561700017
Scopus
84974808938
Mendeley
http://www.mendeley.com/research/vitamin-d-status-not-affect-disability-progression-patients-multiple-sclerosis-three-year-followup-2
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Mendeley | Further Information

{"title"=>"Vitamin D Status Does Not Affect Disability Progression of Patients with Multiple Sclerosis over Three Year Follow-Up", "type"=>"journal", "authors"=>[{"first_name"=>"Anne-Hilde", "last_name"=>"Muris"}, {"first_name"=>"Joost", "last_name"=>"Smolders"}, {"first_name"=>"Linda", "last_name"=>"Rolf"}, {"first_name"=>"Lieke J. J.", "last_name"=>"Klinkenberg"}, {"first_name"=>"Noreen", "last_name"=>"van der Linden"}, {"first_name"=>"Steven", "last_name"=>"Meex"}, {"first_name"=>"Jan", "last_name"=>"Damoiseaux"}, {"first_name"=>"Raymond", "last_name"=>"Hupperts"}], "year"=>2016, "source"=>"PLOS ONE", "identifiers"=>{"pmid"=>"27276080", "issn"=>"1932-6203", "doi"=>"10.1371/journal.pone.0156122"}, "id"=>"a749f594-72d1-3724-90ff-028525caaae7", "abstract"=>"Background and Objective The risk of developing multiple sclerosis (MS) as well asMS disease activity is associated with vitamin D (25(OH)D) status. The relationship between themain functional disability hallmark of MS, disability progression, and 25(OH)D status is less well established though, especially not inMS patients with progressive disease. Methods This retrospective follow-up study included 554 MS patients with a serum baseline 25(OH) D level and Expanded Disability Status Scale (EDSS) with a minimum follow-up of three years. Logistic regressions were performed to assess the effect of baseline 25(OH)D status on relapse rate. Repeatedmeasures linear regression analyses were performed to assess the effect on disability and disability progression. Results Baseline deseasonalized 25(OH)D status was associated with subsequent relapse risk (yes/no), but only in the youngerMS patients ( 37.5 years; OR= 0.872, per 10 nmol/L 25 (OH)D, p = 0.041). Baseline 25(OH)D status was not significantly associated with either dis- ability or disability progression, irrespective ofMS phenotype. Conclusion Within the physiological range, 25(OH)D status is just significantly associated with the occurrence of relapses in younger MS patients, but is not associated with disability or dis- ability progression over three years follow-up. Whether high dose supplementation to supra physiological 25(OH)D levels prevents disability progression in MSshould become clear from long term follow-up of supplementation studies.", "link"=>"http://www.mendeley.com/research/vitamin-d-status-not-affect-disability-progression-patients-multiple-sclerosis-three-year-followup-2", "reader_count"=>21, "reader_count_by_academic_status"=>{"Researcher"=>2, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>4, "Other"=>2, "Student > Master"=>1, "Student > Bachelor"=>5, "Lecturer"=>1}, "reader_count_by_user_role"=>{"Researcher"=>2, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>4, "Other"=>2, "Student > Master"=>1, "Student > Bachelor"=>5, "Lecturer"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Environmental Science"=>1, "Nursing and Health Professions"=>3, "Medicine and Dentistry"=>10, "Agricultural and Biological Sciences"=>2, "Neuroscience"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Social Sciences"=>1, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>10}, "Neuroscience"=>{"Neuroscience"=>1}, "Social Sciences"=>{"Social Sciences"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>3}, "Unspecified"=>{"Unspecified"=>1}, "Environmental Science"=>{"Environmental Science"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"Mexico"=>1}, "group_count"=>0}

Scopus | Further Information

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