Expression Profile and Function Analysis of LncRNAs during Priming Phase of Rat Liver Regeneration
Publication Date
June 21, 2016
Journal
PLOS ONE
Authors
Jun Li, Wei Jin, Yanli Qin, Weiming Zhao, et al
Volume
11
Issue
6
Pages
e0156128
DOI
https://dx.plos.org/10.1371/journal.pone.0156128
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0156128
Web of Science
000378212400002
Scopus
84976892793
Mendeley
http://www.mendeley.com/research/expression-profile-function-analysis-lncrnas-during-priming-phase-rat-liver-regeneration
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Mendeley | Further Information

{"title"=>"Expression profile and function analysis of LncRNAs during priming phase of rat liver regeneration", "type"=>"journal", "authors"=>[{"first_name"=>"Jun", "last_name"=>"Li", "scopus_author_id"=>"57190047894"}, {"first_name"=>"Wei", "last_name"=>"Jin", "scopus_author_id"=>"57190045763"}, {"first_name"=>"Yanli", "last_name"=>"Qin", "scopus_author_id"=>"56768607300"}, {"first_name"=>"Weiming", "last_name"=>"Zhao", "scopus_author_id"=>"55545509600"}, {"first_name"=>"Cuifang", "last_name"=>"Chang", "scopus_author_id"=>"8776635900"}, {"first_name"=>"Cunshuan", "last_name"=>"Xu", "scopus_author_id"=>"7404181623"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84976892793", "scopus"=>"2-s2.0-84976892793", "pui"=>"610977599", "isbn"=>"1423004132", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0156128"}, "id"=>"0ef3bf99-cb39-3be5-954e-422713e79663", "abstract"=>"Emerging evidences have revealed that long non-coding RNAs (lncRNAs) functioned in a wide range of physiological and pathophysiological processes including rat liver regeneration, and could regulate gene expression in the transcriptional and post-transcriptional levels. However, the underlying mechanism for lncRNAs participation in liver regeneration is largely unknown. To define the mechanisms how the lncRNAs regulate LR, we performed bio-chip technology, high-throughput sequencing and RT-PCR to detect the expression of lncRNAs at 0, 2 and 6 h during LR after 2/3 hepatectomy (PH). The results indicated that 28 lncRNAs were involved in LR. Bioinformatics analysis predicated 465 co-expression target genes including 10 regulatory genes were related to these 28 lncRNAs. Ingenuity Pathway Analysis (IPA) was employed to analyze the signaling pathways and physiological activities that regulated by these genes, and the results suggested that these genes were potentially related to ILK, SAPK/JNK and ERK/MAPK signaling pathways, and possibly regulate many important physiological activities in LR in terms of cell proliferation, cell differentiation, cell survival, apoptosis and necrosis.", "link"=>"http://www.mendeley.com/research/expression-profile-function-analysis-lncrnas-during-priming-phase-rat-liver-regeneration", "reader_count"=>4, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Student > Ph. D. Student"=>2, "Student > Master"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Student > Ph. D. Student"=>2, "Student > Master"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Medicine and Dentistry"=>2, "Agricultural and Biological Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Unspecified"=>{"Unspecified"=>1}}, "group_count"=>0}

Scopus | Further Information

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