Do Low Molecular Weight Agents Cause More Severe Asthma than High Molecular Weight Agents?
Publication Date
June 09, 2016
Journal
PLOS ONE
Authors
Olga Meca, María Jesús Cruz, Mónica Sánchez Ortiz, Francisco Javier González Barcala, et al
Volume
11
Issue
6
Pages
e0156141
DOI
https://dx.plos.org/10.1371/journal.pone.0156141
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0156141
Web of Science
000377563000016
Scopus
84976332528
Mendeley
http://www.mendeley.com/research/low-molecular-weight-agents-cause-more-severe-asthma-high-molecular-weight-agents-1
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Mendeley | Further Information

{"title"=>"Do Low Molecular Weight Agents Cause More Severe Asthma than High Molecular Weight Agents?", "type"=>"journal", "authors"=>[{"first_name"=>"Olga", "last_name"=>"Meca"}, {"first_name"=>"María-Jesús", "last_name"=>"Cruz"}, {"first_name"=>"Mónica", "last_name"=>"Sánchez-Ortiz"}, {"first_name"=>"Francisco-Javier", "last_name"=>"González-Barcala"}, {"first_name"=>"Iñigo", "last_name"=>"Ojanguren"}, {"first_name"=>"Xavier", "last_name"=>"Munoz"}], "year"=>2016, "source"=>"PloS one", "identifiers"=>{"issn"=>"1932-6203", "doi"=>"10.1371/journal.pone.0156141", "pmid"=>"27280473"}, "id"=>"1f868eda-b708-390f-b52e-13b8b4887eb7", "abstract"=>"INTRODUCTION The aim of this study was to analyse whether patients with occupational asthma (OA) caused by low molecular weight (LMW) agents differed from patients with OA caused by high molecular weight (HMW) with regard to risk factors, asthma presentation and severity, and response to various diagnostic tests. METHODS Seventy-eight patients with OA diagnosed by positive specific inhalation challenge (SIC) were included. Anthropometric characteristics, atopic status, occupation, latency periods, asthma severity according to the Global Initiative for Asthma (GINA) control classification, lung function tests and SIC results were analysed. RESULTS OA was induced by an HMW agent in 23 patients (29%) and by an LMW agent in 55 (71%). A logistic regression analysis confirmed that patients with OA caused by LMW agents had a significantly higher risk of severity according to the GINA classification after adjusting for potential confounders (OR = 3.579, 95% CI 1.136-11.280; p = 0.029). During the SIC, most patients with OA caused by HMW agents presented an early reaction (82%), while in patients with OA caused by LMW agents the response was mainly late (73%) (p = 0.0001). Similarly, patients with OA caused by LMW agents experienced a greater degree of bronchial hyperresponsiveness, measured as the difference in the methacholine dose-response ratio (DRR) before and after SIC (1.77, range 0-16), compared with patients with OA caused by HMW agents (0.87, range 0-72), (p = 0.024). CONCLUSIONS OA caused by LMW agents may be more severe than that caused by HMW agents. The severity of the condition may be determined by the different mechanisms of action of these agents.", "link"=>"http://www.mendeley.com/research/low-molecular-weight-agents-cause-more-severe-asthma-high-molecular-weight-agents-1", "reader_count"=>2, "reader_count_by_academic_status"=>{"Researcher"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Researcher"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Medicine and Dentistry"=>1, "Agricultural and Biological Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}}, "group_count"=>0}

Scopus | Further Information

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