Efficacy and Safety of the Collagenase of the Bacterium Clostridium Histolyticum for the Treatment of Capsular Contracture after Silicone Implants: Ex-Vivo Study on Human Tissue
Publication Date
May 27, 2016
Journal
PLOS ONE
Authors
Sebastian Fischer, Christoph Hirche, Yannick Diehm, Kristo Nuutila, et al
Volume
11
Issue
5
Pages
e0156428
DOI
https://dx.plos.org/10.1371/journal.pone.0156428
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0156428
Scopus
84971611829
Mendeley
http://www.mendeley.com/research/efficacy-safety-collagenase-bacterium-clostridium-histolyticum-treatment-capsular-contracture-after
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Mendeley | Further Information

{"title"=>"Efficacy and safety of the collagenase of the bacterium clostridium histolyticum for the treatment of capsular contracture after silicone implants: Ex-vivo study on human tissue", "type"=>"journal", "authors"=>[{"first_name"=>"Sebastian", "last_name"=>"Fischer", "scopus_author_id"=>"56435266800"}, {"first_name"=>"Christoph", "last_name"=>"Hirche", "scopus_author_id"=>"35203295600"}, {"first_name"=>"Yannick", "last_name"=>"Diehm", "scopus_author_id"=>"56690533800"}, {"first_name"=>"Kristo", "last_name"=>"Nuutila", "scopus_author_id"=>"55445058500"}, {"first_name"=>"Jurij", "last_name"=>"Kiefer", "scopus_author_id"=>"55119627900"}, {"first_name"=>"Emre", "last_name"=>"Gazyakan", "scopus_author_id"=>"8986499400"}, {"first_name"=>"Ericka M.", "last_name"=>"Bueno", "scopus_author_id"=>"37120055200"}, {"first_name"=>"Thomas", "last_name"=>"Kremer", "scopus_author_id"=>"6603028310"}, {"first_name"=>"Ulrich", "last_name"=>"Kneser", "scopus_author_id"=>"26643400800"}, {"first_name"=>"Bohdan", "last_name"=>"Pomahac", "scopus_author_id"=>"6602461627"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"isbn"=>"1932-6203", "issn"=>"19326203", "pmid"=>"27232716", "sgr"=>"84971611829", "pui"=>"610575932", "scopus"=>"2-s2.0-84971611829", "doi"=>"10.1371/journal.pone.0156428"}, "id"=>"e0864224-803a-37e7-bba1-814d1c0cadae", "abstract"=>"BACKGROUND: The fibrotic capsule that surrounds silicone implants consists mainly of collagen. The FDA-approved collagenase of the bacterium clostridium histolyticum provides a reasonable treatment option. Safety and efficacy at the female breast site must be evaluated before clinical utilization.\\n\\nMATERIALS AND METHODS: We incubated 20 samples of fibrotic capsule as well as 12 full thickness skin grafts harvested from the female breast site for 24 hours with different doses of collagenase. Outcome measures involved histological assessment of thickness and density of the capsule tissue as well as the skin grafts. Furthermore, we performed a collagen assay and immunohistochemistry staining for collagen subtypes.\\n\\nRESULTS: Collagenase treatment was able to degrade human capsule contracture tissue ex-vivo. The remaining collagen subtype after degradation was type 4 only. 0.3 mg/ml of collagenase was most effective in reducing capsule thickness when compared with higher concentrations. Of note, effectiveness was inversely related to capsule density, such that there was less reduction in thickness with higher capsule densities and vice versa. Furthermore, the application of 0.3mg/ml collagenase did not lead to thinning or perforation of full thickness skin grafts.\\n\\nCONCLUSION: Adjustment of collagenase dose will depend on thickness and density of the contracted capsule. A concentration of 0.3mg/ml seems to be safe and effective in an ex-vivo setting. The remaining collagen subtype 4 is suitable to serve as a neo-capsule/acellular tissue matrix. Collagenase treatment for capsular contracture may soon become a clinical reality.", "link"=>"http://www.mendeley.com/research/efficacy-safety-collagenase-bacterium-clostridium-histolyticum-treatment-capsular-contracture-after", "reader_count"=>16, "reader_count_by_academic_status"=>{"Unspecified"=>3, "Professor > Associate Professor"=>2, "Researcher"=>2, "Student > Master"=>2, "Other"=>3, "Student > Bachelor"=>3, "Lecturer"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>3, "Professor > Associate Professor"=>2, "Researcher"=>2, "Student > Master"=>2, "Other"=>3, "Student > Bachelor"=>3, "Lecturer"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>4, "Medicine and Dentistry"=>9, "Agricultural and Biological Sciences"=>3}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>9}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Unspecified"=>{"Unspecified"=>4}}, "group_count"=>1}

Scopus | Further Information

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