Nonhuman Primate IFITM Proteins Are Potent Inhibitors of HIV and SIV
Publication Date
June 03, 2016
Journal
PLOS ONE
Authors
Jordan Wilkins, Yi Min Zheng, Jingyou Yu, Chen Liang, et al
Volume
11
Issue
6
Pages
e0156739
DOI
https://dx.plos.org/10.1371/journal.pone.0156739
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0156739
Web of Science
000377369700118
Scopus
84974829708
Mendeley
http://www.mendeley.com/research/nonhuman-primate-ifitm-proteins-potent-inhibitors-hiv-siv
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Mendeley | Further Information

{"title"=>"Nonhuman primate IFITM proteins are potent inhibitors of HIV and SIV", "type"=>"journal", "authors"=>[{"first_name"=>"Jordan", "last_name"=>"Wilkins", "scopus_author_id"=>"56352483100"}, {"first_name"=>"Yi Min", "last_name"=>"Zheng", "scopus_author_id"=>"10638840400"}, {"first_name"=>"Jingyou", "last_name"=>"Yu", "scopus_author_id"=>"56849587500"}, {"first_name"=>"Chen", "last_name"=>"Liang", "scopus_author_id"=>"7403280493"}, {"first_name"=>"Shan Lu", "last_name"=>"Liu", "scopus_author_id"=>"7409461598"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84974829708", "sgr"=>"84974829708", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0156739", "pmid"=>"27257969", "pui"=>"610615493"}, "id"=>"151adb95-0308-3f3c-8fd8-04871c6230dd", "abstract"=>"Interferon-induced transmembrane (IFITM) proteins are potent antiviral factors shown to restrict the infection of many enveloped viruses, including HIV. Here we report cloning and characterization of a panel of nonhuman primate IFITMs. We show that, similar to human IFITM, nonhuman primate IFITM proteins inhibit HIV and other primate lentiviruses. While some nonhuman primate IFITM proteins are more potent than human counterparts to inhibit HIV-1, they are generally not effective against HIV-2 similar to that of human IFITMs. Nota-bly, depending on SIV strains and also IFITM species tested, nonhuman primate IFITM pro-teins exhibit distinct activities against SIVs; no correlation was found to support the notion that IFITM proteins are most active in non-natural primate hosts. Consistent with our recent findings for human IFITMs, nonhuman primate IFITM proteins interact with HIV-1 Env and strongly act in viral producer cells to impair viral infectivity and block cell-to-cell transmis-sion. Accordingly, knockdown of primate IFITM3 increases HIV-1 replication in nohuman primate cells. Interestingly, analysis of DNA sequences of human and nonhuman primate IFITMs suggest that IFITM proteins have been undergoing purifying selection, rather than positive selection typical for cellular restriction factors. Overall, our study reveals some new and unexpected features of IFITMs in restricting primate lentiviruses, which enhances our understanding of virus-host interaction and AIDS pathogenesis.", "link"=>"http://www.mendeley.com/research/nonhuman-primate-ifitm-proteins-potent-inhibitors-hiv-siv", "reader_count"=>16, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Researcher"=>3, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>1, "Student > Master"=>1, "Professor"=>1, "Other"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Researcher"=>3, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>1, "Student > Master"=>1, "Professor"=>1, "Other"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>2, "Agricultural and Biological Sciences"=>7, "Medicine and Dentistry"=>2, "Immunology and Microbiology"=>5}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>5}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>7}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}}, "group_count"=>0}

Scopus | Further Information

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