Ultrasound Microbubble Treatment Enhances Clathrin-Mediated Endocytosis and Fluid-Phase Uptake through Distinct Mechanisms
Publication Date
June 08, 2016
Journal
PLOS ONE
Authors
Farnaz Fekri, Ralph Christian Delos Santos, Raffi Karshafian & Costin N. Antonescu
Volume
11
Issue
6
Pages
e0156754
DOI
https://dx.plos.org/10.1371/journal.pone.0156754
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0156754
Scopus
84974777494
Mendeley
http://www.mendeley.com/research/ultrasound-microbubble-treatment-enhances-clathrinmediated-endocytosis-fluidphase-uptake-through-dis
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Mendeley | Further Information

{"title"=>"Ultrasound microbubble treatment enhances clathrin-mediated endocytosis and fluid-phase uptake through distinct mechanisms", "type"=>"journal", "authors"=>[{"first_name"=>"Farnaz", "last_name"=>"Fekri", "scopus_author_id"=>"57189712705"}, {"first_name"=>"Ralph Christian", "last_name"=>"Delos Santos", "scopus_author_id"=>"56725675900"}, {"first_name"=>"Raffi", "last_name"=>"Karshafian", "scopus_author_id"=>"6506027068"}, {"first_name"=>"Costin N.", "last_name"=>"Antonescu", "scopus_author_id"=>"8660899800"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84974777494", "pui"=>"610786587", "doi"=>"10.1371/journal.pone.0156754", "sgr"=>"84974777494", "pmid"=>"27275866"}, "id"=>"b4d326e4-6e6d-3abe-a0f2-aea73f726cc5", "abstract"=>"Drug delivery to tumors is limited by several factors, including drug permeability of the target cell plasma membrane. Ultrasound in combination with microbubbles (USMB) is a promising strategy to overcome these limitations. USMB treatment elicits enhanced cellular uptake of materials such as drugs, in part as a result of sheer stress and formation of transient membrane pores. Pores formed upon USMB treatment are rapidly resealed, suggesting that other processes such as enhanced endocytosis may contribute to the enhanced material uptake by cells upon USMB treatment. How USMB regulates endocytic processes remains incompletely understood. Cells constitutively utilize several distinct mechanisms of endocytosis, including clathrin-mediated endocytosis (CME) for the internalization of receptor-bound macromolecules such as Transferrin Receptor (TfR), and distinct mechanism(s) that mediate the majority of fluid-phase endocytosis. Tracking the abundance of TfR on the cell surface and the internalization of its ligand transferrin revealed that USMB acutely enhances the rate of CME. Total internal reflection fluorescence microscopy experiments revealed that USMB treatment altered the assembly of clathrin-coated pits, the basic structural units of CME. In addition, the rate of fluid-phase endocytosis was enhanced, but with delayed onset upon USMB treatment relative to the enhancement of CME, suggesting that the two processes are distinctly regulated by USMB. Indeed, vacuolin-1 or desipramine treatment prevented the enhancement of CME but not of fluid phase endocytosis upon USMB, suggesting that lysosome exocytosis and acid sphingomyelinase, respectively, are required for the regulation of CME but not fluid phase endocytosis upon USMB treatment. These results indicate that USMB enhances both CME and fluid phase endocytosis through distinct signaling mechanisms, and suggest that strategies for potentiating the enhancement of endocytosis upon USMB treatment may improve targeted drug delivery.", "link"=>"http://www.mendeley.com/research/ultrasound-microbubble-treatment-enhances-clathrinmediated-endocytosis-fluidphase-uptake-through-dis", "reader_count"=>14, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>2, "Librarian"=>1, "Student > Ph. D. Student"=>4, "Student > Master"=>2, "Student > Bachelor"=>1, "Professor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>2, "Librarian"=>1, "Student > Ph. D. Student"=>4, "Student > Master"=>2, "Student > Bachelor"=>1, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Engineering"=>6, "Biochemistry, Genetics and Molecular Biology"=>2, "Agricultural and Biological Sciences"=>2, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Physics and Astronomy"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>6}, "Physics and Astronomy"=>{"Physics and Astronomy"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>2}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"United States"=>1}, "group_count"=>1}

Scopus | Further Information

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