Serum-Based Oxylipins Are Associated with Outcomes in Primary Prevention Implantable Cardioverter Defibrillator Patients
Publication Date
June 09, 2016
Journal
PLOS ONE
Authors
Yiyi Zhang, Eliseo Guallar, Elena Blasco Colmenares, Amy C. Harms, et al
Volume
11
Issue
6
Pages
e0157035
DOI
https://dx.plos.org/10.1371/journal.pone.0157035
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0157035
Web of Science
000377563000071
Scopus
84976291786
Mendeley
http://www.mendeley.com/research/serumbased-oxylipins-associated-outcomes-primary-prevention-implantable-cardioverter-defibrillator-p-3
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Mendeley | Further Information

{"title"=>"Serum-based oxylipins are associated with outcomes in primary prevention implantable cardioverter defibrillator patients", "type"=>"journal", "authors"=>[{"first_name"=>"Yiyi", "last_name"=>"Zhang", "scopus_author_id"=>"35304223900"}, {"first_name"=>"Eliseo", "last_name"=>"Guallar", "scopus_author_id"=>"7003727498"}, {"first_name"=>"Elena", "last_name"=>"Blasco-Colmenares", "scopus_author_id"=>"6508087378"}, {"first_name"=>"Amy C.", "last_name"=>"Harms", "scopus_author_id"=>"7006631122"}, {"first_name"=>"Rob J.", "last_name"=>"Vreeken", "scopus_author_id"=>"6602559274"}, {"first_name"=>"Thomas", "last_name"=>"Hankemeier", "scopus_author_id"=>"8560890900"}, {"first_name"=>"Gordon F.", "last_name"=>"Tomaselli", "scopus_author_id"=>"7005223451"}, {"first_name"=>"Alan", "last_name"=>"Cheng", "scopus_author_id"=>"35078339000"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84976291786", "sgr"=>"84976291786", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0157035", "pmid"=>"27281224", "pui"=>"610893108"}, "id"=>"22fd126b-b7fa-341d-be61-cab0b27e64a9", "abstract"=>"INTRODUCTION Individuals with systolic heart failure are at risk of ventricular arrhythmias and all-cause mortality. Little is known regarding the mechanisms underlying these events. We sought to better understand if oxylipins, a diverse class of lipid metabolites derived from the oxidation of polyunsaturated fatty acids, were associated with these outcomes in recipients of primary prevention implantable cardioverter defibrillators (ICDs). METHODS Among 479 individuals from the PROSE-ICD study, baseline serum were analyzed and quantitatively profiled for 35 known biologically relevant oxylipin metabolites. Associations with ICD shocks for ventricular arrhythmias and all-cause mortality were evaluated using Cox proportional hazards models. RESULTS Six oxylipins, 17,18-DiHETE (HR = 0.83, 95% CI 0.70 to 0.99 per SD change in oxylipin level), 19,20-DiHDPA (HR = 0.79, 95% CI 0.63 to 0.98), 5,6-DiHETrE (HR = 0.73, 95% CI 0.58 to 0.91), 8,9-DiHETrE (HR = 0.76, 95% CI 0.62 to 0.95), 9,10-DiHOME (HR = 0.81, 95% CI 0.65 to 1.00), and PGF1α (HR = 1.33, 95% CI 1.04 to 1.71) were associated with the risk of appropriate ICD shock after multivariate adjustment for clinical factors. Additionally, 4 oxylipin-to-precursor ratios, 15S-HEPE / FA (20:5-ω3), 17,18-DiHETE / FA (20:5-ω3), 19,20-DiHDPA / FA (20:5-ω3), and 5S-HEPE / FA (20:5-ω3) were positively associated with the risk of all-cause mortality. CONCLUSION In a prospective cohort of patients with primary prevention ICDs, we identified several novel oxylipin markers that were associated with appropriate shock and mortality using metabolic profiling techniques. These findings may provide new insight into the potential biologic pathways leading to adverse events in this patient population.", "link"=>"http://www.mendeley.com/research/serumbased-oxylipins-associated-outcomes-primary-prevention-implantable-cardioverter-defibrillator-p-3", "reader_count"=>7, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>4, "Student > Bachelor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>4, "Student > Bachelor"=>1}, "reader_count_by_subject_area"=>{"Engineering"=>1, "Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>1, "Medicine and Dentistry"=>1, "Agricultural and Biological Sciences"=>2, "Chemistry"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Chemistry"=>{"Chemistry"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"United States"=>1}, "group_count"=>0}

Scopus | Further Information

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