Mapping Alterations to the Endogenous Elemental Distribution within the Lateral Ventricles and Choroid Plexus in Brain Disorders Using X-Ray Fluorescence Imaging
Publication Date
June 28, 2016
Journal
PLOS ONE
Authors
Brittney R. Lins, Jake M. Pushie, Michael Jones, Daryl L. Howard, et al
Volume
11
Issue
6
Pages
e0158152
DOI
https://dx.plos.org/10.1371/journal.pone.0158152
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0158152
Scopus
84978066614
Mendeley
http://www.mendeley.com/research/mapping-alterations-endogenous-elemental-distribution-within-lateral-ventricles-choroid-plexus-brain-1
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Mendeley | Further Information

{"title"=>"Mapping alterations to the endogenous elemental distribution within the lateral ventricles and choroid plexus in brain disorders using X-ray fluorescence imaging", "type"=>"journal", "authors"=>[{"first_name"=>"Brittney R.", "last_name"=>"Lins", "scopus_author_id"=>"55978122000"}, {"first_name"=>"Jake M.", "last_name"=>"Pushie", "scopus_author_id"=>"57190161394"}, {"first_name"=>"Michael", "last_name"=>"Jones", "scopus_author_id"=>"55522309100"}, {"first_name"=>"Daryl L.", "last_name"=>"Howard", "scopus_author_id"=>"7202305266"}, {"first_name"=>"John G.", "last_name"=>"Howland", "scopus_author_id"=>"26643319400"}, {"first_name"=>"Mark J.", "last_name"=>"Hackett", "scopus_author_id"=>"35240056500"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84978066614", "pui"=>"611145107", "issn"=>"19326203", "scopus"=>"2-s2.0-84978066614", "doi"=>"10.1371/journal.pone.0158152"}, "id"=>"ae9ef203-54e8-33e0-b249-ec532fcfca58", "abstract"=>"The choroid plexus and cerebral ventricles are critical structures for the production of cere-bral spinal fluid (CSF) and play an important role in regulating ion and metal transport in the brain, however many aspects of its roles in normal physiology and disease states, such as psychiatric illness, remain unknown. The choroid plexus is difficult to examine in vivo, and in situ ex vivo, and as such has typically been examined indirectly with radiolabeled tracers or ex vivo stains, making measurements of the endogenous K + , Cl − , and Ca + distributions unreliable. In the present study, we directly examined the distribution of endogenous ions and biologically relevant transition metals in the choroid plexus and regions surrounding the ventricles (ventricle wall, cortex, corpus callosum, striatum) using X-ray fluorescence imag-ing (XFI). We find that the choroid plexus was rich in Cl − and Fe while K + levels increase fur-ther from the ventricle as Cl − levels decrease, consistent with the known role of ion transporters in the choroid plexus CSF production. A polyI:C offspring displayed enlarged ventricles, elevated Cl − surrounding the ventricles, and intraventricular calcifications. These observations fit with clinical findings in patients with schizophrenia and suggest maternal treatment with polyI:C may lead to dysfunctional ion regulation in offspring. This study dem-onstrates the power of XFI for examining the endogenous elemental distributions of the ven-tricular system in healthy brain tissue as well as disease models.", "link"=>"http://www.mendeley.com/research/mapping-alterations-endogenous-elemental-distribution-within-lateral-ventricles-choroid-plexus-brain-1", "reader_count"=>7, "reader_count_by_academic_status"=>{"Researcher"=>2, "Student > Ph. D. Student"=>3, "Other"=>1, "Student > Bachelor"=>1}, "reader_count_by_user_role"=>{"Researcher"=>2, "Student > Ph. D. Student"=>3, "Other"=>1, "Student > Bachelor"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>2, "Agricultural and Biological Sciences"=>1, "Neuroscience"=>3, "Pharmacology, Toxicology and Pharmaceutical Science"=>1}, "reader_count_by_subdiscipline"=>{"Neuroscience"=>{"Neuroscience"=>3}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "group_count"=>0}

Scopus | Further Information

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