The Use and Reporting of the Cross-Over Study Design in Clinical Trials and Systematic Reviews: A Systematic Assessment
Publication Date
July 13, 2016
Journal
PLOS ONE
Authors
Sarah Jane Nolan, Ian Hambleton & Kerry Dwan
Volume
11
Issue
7
Pages
e0159014
DOI
https://dx.plos.org/10.1371/journal.pone.0159014
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0159014
Scopus
84978715207
Mendeley
http://www.mendeley.com/research/reporting-crossover-study-design-clinical-trials-systematic-reviews-systematic-assessment
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Mendeley | Further Information

{"title"=>"The use and reporting of the cross-over study design in clinical trials and systematic reviews: A systematic assessment", "type"=>"generic", "authors"=>[{"first_name"=>"Sarah Jane", "last_name"=>"Nolan", "scopus_author_id"=>"55618646200"}, {"first_name"=>"Ian", "last_name"=>"Hambleton", "scopus_author_id"=>"35233247100"}, {"first_name"=>"Kerry", "last_name"=>"Dwan", "scopus_author_id"=>"25027473800"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"27409076", "issn"=>"19326203", "sgr"=>"84978715207", "pui"=>"611245414", "scopus"=>"2-s2.0-84978715207", "doi"=>"10.1371/journal.pone.0159014"}, "id"=>"def7284f-857e-360a-8577-a3a4478637dd", "abstract"=>"BACKGROUND Systematic reviews of treatment interventions in stable or chronic conditions often require the synthesis of clinical trials with a cross-over design. Previous work has indicated that methodology for analysing cross-over data is inadequate in trial reports and in systematic reviews assessing trials with this design. OBJECTIVE We assessed systematic review methodology for synthesising cross-over trials among Cochrane Cystic Fibrosis and Genetic Disorders Group reviews published to July 2015, and assessed the quality of reporting among the cross-over trials included in these reviews. METHODOLOGY We performed data extraction of methodology and reporting in reviews, trials identified and trials included within reviews. PRINCIPAL FINDINGS We reviewed a total of 142 Cochrane systematic reviews including 53 reviews which synthesised evidence from 218 cross-over trials. Thirty-three (63%) Cochrane reviews described a clear and appropriate method for the inclusion of cross-over data, and of these 19 (56%) used the same method to analyse results. 145 cross-over trials were described narratively or treated as parallel trials in reviews but in 30 (21%) of these trials data existed in the trial reports to account for the cross-over design. At the trial level, the analysis and presentation of results were often inappropriate or unclear, with only 69 (32%) trials presenting results that could be included in meta-analysis. CONCLUSIONS Despite development of accessible, technical guidance and training for Cochrane systematic reviewers, statistical analysis and reporting of cross-over data is inadequate at both the systematic review and the trial level. Plain language and practical guidance for the inclusion of cross-over data in meta-analysis would benefit systematic reviewers, who come from a wide range of health specialties. Minimum reporting standards for cross-over trials are needed.", "link"=>"http://www.mendeley.com/research/reporting-crossover-study-design-clinical-trials-systematic-reviews-systematic-assessment", "reader_count"=>7, "reader_count_by_academic_status"=>{"Other"=>1, "Student > Master"=>2, "Student > Bachelor"=>2, "Lecturer"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Other"=>1, "Student > Master"=>2, "Student > Bachelor"=>2, "Lecturer"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Nursing and Health Professions"=>1, "Medicine and Dentistry"=>2, "Neuroscience"=>1, "Veterinary Science and Veterinary Medicine"=>1, "Psychology"=>1, "Social Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Neuroscience"=>{"Neuroscience"=>1}, "Social Sciences"=>{"Social Sciences"=>1}, "Psychology"=>{"Psychology"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "group_count"=>1}

Scopus | Further Information

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