Neuromuscular Strain Increases Symptom Intensity in Chronic Fatigue Syndrome
Publication Date
July 18, 2016
Journal
PLOS ONE
Authors
Peter C. Rowe, Kevin R. Fontaine, Megan Lauver, Samantha E. Jasion, et al
Volume
11
Issue
7
Pages
e0159386
DOI
https://dx.plos.org/10.1371/journal.pone.0159386
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0159386
Web of Science
000380169300060
Scopus
84979200937
Mendeley
http://www.mendeley.com/research/neuromuscular-strain-increases-symptom-intensity-chronic-fatigue-syndrome
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Mendeley | Further Information

{"title"=>"Neuromuscular strain increases symptom intensity in chronic fatigue syndrome", "type"=>"journal", "authors"=>[{"first_name"=>"Peter C.", "last_name"=>"Rowe", "scopus_author_id"=>"7201570221"}, {"first_name"=>"Kevin R.", "last_name"=>"Fontaine", "scopus_author_id"=>"7005872112"}, {"first_name"=>"Megan", "last_name"=>"Lauver", "scopus_author_id"=>"57190341903"}, {"first_name"=>"Samantha E.", "last_name"=>"Jasion", "scopus_author_id"=>"56194608100"}, {"first_name"=>"Colleen L.", "last_name"=>"Marden", "scopus_author_id"=>"56194310100"}, {"first_name"=>"Malini", "last_name"=>"Moni", "scopus_author_id"=>"50162004000"}, {"first_name"=>"Carol B.", "last_name"=>"Thompson", "scopus_author_id"=>"34769145200"}, {"first_name"=>"Richard L.", "last_name"=>"Violand", "scopus_author_id"=>"15753035900"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "doi"=>"10.1371/journal.pone.0159386", "sgr"=>"84979200937", "scopus"=>"2-s2.0-84979200937", "isbn"=>"1932-6203 (electronic)", "pmid"=>"27428358", "pui"=>"611323744"}, "id"=>"addaa053-049b-3dd2-8915-b076633e43db", "abstract"=>"Chronic fatigue syndrome (CFS) is a complex, multisystem disorder that can be disabling. CFS symptoms can be provoked by increased physical or cognitive activity, and by orthostatic stress. In preliminary work, we noted that CFS symptoms also could be provoked by application of longitudinal neural and soft tissue strain to the limbs and spine of affected individuals. In this study we measured the responses to a straight leg raise neuromuscular strain maneuver in individuals with CFS and healthy controls. We randomly assigned 60 individuals with CFS and 20 healthy controls to either a 15 minute period of passive supine straight leg raise (true neuromuscular strain) or a sham straight leg raise. The primary outcome measure was the symptom intensity difference between the scores during and 24 hours after the study maneuver compared to baseline. Fatigue, body pain, lightheadedness, concentration difficulties, and headache scores were measured individually on a 0–10 scale, and summed to create a composite symptom score. Compared to individuals with CFS in the sham strain group, those with CFS in the true strain group reported significantly increased body pain (P = 0.04) and concentration difficulties (P = 0.02) as well as increased composite symptom scores (all P = 0.03) during the maneuver. After 24 hours, the symptom intensity differences were significantly greater for the CFS true strain group for the individual symptom of lightheadedness (P = 0.001) and for the composite symptom score (P = 0.005). During and 24 hours after the exposure to the true strain maneuver, those with CFS had significantly higher individual and composite symptom intensity changes compared to the healthy controls. We conclude that a longitudinal strain applied to the nerves and soft tissues of the lower limb is capable of increasing symptom intensity in individuals with CFS for up to 24 hours. These findings support our preliminary observations that increased mechanical sensitivity may be a contributor to the provocation of symptoms in this disorder.", "link"=>"http://www.mendeley.com/research/neuromuscular-strain-increases-symptom-intensity-chronic-fatigue-syndrome", "reader_count"=>22, "reader_count_by_academic_status"=>{"Researcher"=>7, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>1, "Student > Postgraduate"=>1, "Student > Master"=>3, "Other"=>8, "Professor"=>1}, "reader_count_by_user_role"=>{"Researcher"=>7, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>1, "Student > Postgraduate"=>1, "Student > Master"=>3, "Other"=>8, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Environmental Science"=>1, "Biochemistry, Genetics and Molecular Biology"=>2, "Nursing and Health Professions"=>1, "Medicine and Dentistry"=>6, "Agricultural and Biological Sciences"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Physics and Astronomy"=>2, "Psychology"=>1, "Social Sciences"=>3, "Computer Science"=>1, "Immunology and Microbiology"=>1, "Design"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>6}, "Social Sciences"=>{"Social Sciences"=>3}, "Physics and Astronomy"=>{"Physics and Astronomy"=>2}, "Psychology"=>{"Psychology"=>1}, "Unspecified"=>{"Unspecified"=>1}, "Environmental Science"=>{"Environmental Science"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}, "Design"=>{"Design"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Computer Science"=>{"Computer Science"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}}, "reader_count_by_country"=>{"Taiwan"=>1, "Australia"=>1}, "group_count"=>1}

Scopus | Further Information

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