Liver Stiffness Decreases Rapidly in Response to Successful Hepatitis C Treatment and Then Plateaus
Publication Date
July 21, 2016
Journal
PLOS ONE
Authors
Sweta Chekuri, Jillian Nickerson, Kian Bichoupan, Roberta Sefcik, et al
Volume
11
Issue
7
Pages
e0159413
DOI
https://dx.plos.org/10.1371/journal.pone.0159413
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0159413
Web of Science
000380797500072
Scopus
84979679141
Mendeley
http://www.mendeley.com/research/liver-stiffness-decreases-rapidly-response-successful-hepatitis-c-treatment-plateaus
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Mendeley | Further Information

{"title"=>"Liver stiffness decreases rapidly in response to successful hepatitis C treatment and then plateaus", "type"=>"journal", "authors"=>[{"first_name"=>"Sweta", "last_name"=>"Chekuri", "scopus_author_id"=>"56989732200"}, {"first_name"=>"Jillian", "last_name"=>"Nickerson", "scopus_author_id"=>"57190393355"}, {"first_name"=>"Kian", "last_name"=>"Bichoupan", "scopus_author_id"=>"55849699000"}, {"first_name"=>"Roberta", "last_name"=>"Sefcik", "scopus_author_id"=>"56505449000"}, {"first_name"=>"Kamini", "last_name"=>"Doobay", "scopus_author_id"=>"55661493200"}, {"first_name"=>"Sanders", "last_name"=>"Chang", "scopus_author_id"=>"57190388956"}, {"first_name"=>"David", "last_name"=>"DelBello", "scopus_author_id"=>"56442688800"}, {"first_name"=>"Alyson", "last_name"=>"Harty", "scopus_author_id"=>"56442648300"}, {"first_name"=>"Douglas T.", "last_name"=>"Dieterich", "scopus_author_id"=>"7006820965"}, {"first_name"=>"Ponni V.", "last_name"=>"Perumalswami", "scopus_author_id"=>"13005176300"}, {"first_name"=>"Andrea D.", "last_name"=>"Branch", "scopus_author_id"=>"7004389864"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"doi"=>"10.1371/journal.pone.0159413", "sgr"=>"84979679141", "pmid"=>"27442255", "issn"=>"19326203", "scopus"=>"2-s2.0-84979679141", "pui"=>"611362089"}, "id"=>"fed1bd0e-ce0e-3f32-8e91-67a7450c2b5c", "abstract"=>"BACKGROUND AND AIM To investigate the impact of a sustained virological response (SVR) to hepatitis C virus (HCV) treatment on liver stiffness (LS). METHODS LS, measured by transient elastography (FibroScan), demographic and laboratory data of patients treated with interferon (IFN)-containing or IFN-free regimens who had an SVR24 (undetectable HCV viral load 24 weeks after the end of treatment) were analyzed using two-tailed paired t-tests, Mann-Whitney Wilcoxon Signed-rank tests and linear regression. Two time intervals were investigated: pre-treatment to SVR24 and SVR24 to the end of follow-up. LS scores ≥ 12.5 kPa indicated LS-defined cirrhosis. A p-value below 0.05 was considered statistically significant. RESULTS The median age of the patients (n = 100) was 60 years [IQR (interquartile range) 54-64); 72% were male; 60% were Caucasian; and 42% had cirrhosis pre-treatment according to the FibroScan measurement. The median LS score dropped from 10.40 kPa (IQR: 7.25-18.60) pre-treatment to 7.60 kPa (IQR: 5.60-12.38) at SVR24, p <0.01. Among the 42 patients with LS-defined cirrhosis pre-treatment, 25 (60%) of patients still had LS scores ≥ 12.5 kPa at SVR24, indicating the persistence of cirrhosis. The median change in LS was similar in patients receiving IFN-containing and IFN-free regimens: -1.95 kPa (IQR: -5.75 --0.38) versus -2.40 kPa (IQR: -7.70 --0.23), p = 0.74. Among 56 patients with a post-SVR24 LS measurement, the LS score changed by an additional -0.90 kPa (IQR: -2.98-0.5) during a median follow-up time of 1.17 (IQR: 0.88-1.63) years, which was not a statistically significant decrease (p = 0.99). CONCLUSIONS LS decreased from pre-treatment to SVR24, but did not decrease significantly during additional follow-up. Earlier treatment may be needed to reduce the burden of liver disease.", "link"=>"http://www.mendeley.com/research/liver-stiffness-decreases-rapidly-response-successful-hepatitis-c-treatment-plateaus", "reader_count"=>17, "reader_count_by_academic_status"=>{"Researcher"=>1, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>3, "Other"=>3, "Student > Master"=>2, "Student > Bachelor"=>6, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_user_role"=>{"Researcher"=>1, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>3, "Other"=>3, "Student > Master"=>2, "Student > Bachelor"=>6, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Medicine and Dentistry"=>14, "Agricultural and Biological Sciences"=>1, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>14}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Unspecified"=>{"Unspecified"=>1}}, "group_count"=>1}

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