Feasibility of Human Amniotic Fluid Derived Stem Cells in Alleviation of Neuropathic Pain in Chronic Constrictive Injury Nerve Model
Publication Date
July 21, 2016
Journal
PLOS ONE
Authors
Chien Yi Chiang, Shih An Liu, Meei Ling Sheu, Fu Chou Chen, et al
Volume
11
Issue
7
Pages
e0159482
DOI
https://dx.plos.org/10.1371/journal.pone.0159482
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0159482
Scopus
84979663999
Mendeley
http://www.mendeley.com/research/feasibility-human-amniotic-fluid-derived-stem-cells-alleviation-neuropathic-pain-chronic-constrictiv
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Mendeley | Further Information

{"title"=>"Feasibility of human amniotic fluid derived stem cells in alleviation of neuropathic pain in chronic constrictive injury nerve model", "type"=>"journal", "authors"=>[{"first_name"=>"Chien Yi", "last_name"=>"Chiang", "scopus_author_id"=>"56001728800"}, {"first_name"=>"Shih An", "last_name"=>"Liu", "scopus_author_id"=>"8624834200"}, {"first_name"=>"Meei Ling", "last_name"=>"Sheu", "scopus_author_id"=>"8260269400"}, {"first_name"=>"Fu Chou", "last_name"=>"Chen", "scopus_author_id"=>"57190390600"}, {"first_name"=>"Chun Jung", "last_name"=>"Chen", "scopus_author_id"=>"57135682600"}, {"first_name"=>"Hong Lin", "last_name"=>"Su", "scopus_author_id"=>"34870718400"}, {"first_name"=>"Hung Chuan", "last_name"=>"Pan", "scopus_author_id"=>"57145818800"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"611362048", "sgr"=>"84979663999", "issn"=>"19326203", "pmid"=>"27441756", "scopus"=>"2-s2.0-84979663999", "doi"=>"10.1371/journal.pone.0159482"}, "id"=>"e39b67d6-8a41-35b3-8c4f-c31dfbf1b4a6", "abstract"=>"PURPOSE: The neurobehavior of neuropathic pain by chronic constriction injury (CCI) of sciatic nerve is very similar to that in humans, and it is accompanied by a profound local inflammation response. In this study, we assess the potentiality of human amniotic fluid derived mesenchymal stem cells (hAFMSCs) for alleviating the neuropathic pain in a chronic constriction nerve injury model. METHODS AND METHODS: This neuropathic pain animal model was conducted by four 3-0 chromic gut ligatures loosely ligated around the left sciatic nerve in Sprague-Dawley rats. The intravenous administration of hAFMSCs with 5x105 cells was conducted for three consecutive days. RESULTS: The expression IL-1beta, TNF-alpha and synaptophysin in dorsal root ganglion cell culture was remarkably attenuated when co-cultured with hAFMSCs. The significant decrease of PGP 9.5 in the skin after CCI was restored by administration of hAFMSCs. Remarkably increased expression of CD 68 and TNF-alpha and decreased S-100 and neurofilament expression in injured nerve were rescued by hAFMSCs administration. Increases in synaptophysin and TNF-alpha over the dorsal root ganglion were attenuated by hAFMSCs. Significant expression of TNF-alpha and OX-42 over the dorsal spinal cord was substantially attenuated by hAFMSCs. The increased amplitude of sensory evoked potential as well as expression of synaptophysin and TNF-alpha expression was alleviated by hAFMSCs. Human AFMSCs significantly improved the threshold of mechanical allodynia and thermal hyperalgesia as well as various parameters of CatWalk XT gait analysis. CONCLUSION: Human AFMSCs administration could alleviate the neuropathic pain demonstrated in histomorphological alteration and neurobehavior possibly through the modulation of the inflammatory response.", "link"=>"http://www.mendeley.com/research/feasibility-human-amniotic-fluid-derived-stem-cells-alleviation-neuropathic-pain-chronic-constrictiv", "reader_count"=>13, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Researcher"=>5, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>1, "Student > Postgraduate"=>1, "Student > Master"=>2, "Other"=>1, "Student > Bachelor"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Researcher"=>5, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>1, "Student > Postgraduate"=>1, "Student > Master"=>2, "Other"=>1, "Student > Bachelor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Biochemistry, Genetics and Molecular Biology"=>1, "Nursing and Health Professions"=>2, "Medicine and Dentistry"=>4, "Agricultural and Biological Sciences"=>3, "Psychology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>4}, "Psychology"=>{"Psychology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>2}}, "group_count"=>2}

Scopus | Further Information

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