Tyrosine Phosphorylation of SGEF Regulates RhoG Activity and Cell Migration
Publication Date
July 20, 2016
Journal
PLOS ONE
Authors
Yusuke Okuyama, Kentaro Umeda, Manabu Negishi & Hironori Katoh
Volume
11
Issue
7
Pages
e0159617
DOI
https://dx.plos.org/10.1371/journal.pone.0159617
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0159617
Scopus
84979243603
Mendeley
http://www.mendeley.com/research/tyrosine-phosphorylation-sgef-regulates-rhog-activity-cell-migration
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Mendeley | Further Information

{"title"=>"Tyrosine phosphorylation of SGEF regulates RhoG activity and cell migration", "type"=>"journal", "authors"=>[{"first_name"=>"Yusuke", "last_name"=>"Okuyama", "scopus_author_id"=>"57190345082"}, {"first_name"=>"Kentaro", "last_name"=>"Umeda", "scopus_author_id"=>"56645966400"}, {"first_name"=>"Manabu", "last_name"=>"Negishi", "scopus_author_id"=>"7202704879"}, {"first_name"=>"Hironori", "last_name"=>"Katoh", "scopus_author_id"=>"7201945112"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "pui"=>"611323549", "pmid"=>"27437949", "doi"=>"10.1371/journal.pone.0159617", "sgr"=>"84979243603", "scopus"=>"2-s2.0-84979243603"}, "id"=>"d31b0049-bfe2-34d8-8943-c396ab7c9e22", "abstract"=>"SGEF and Ephexin4 are members of the Ephexin subfamily of RhoGEFs that specifically activate the small GTPase RhoG. It is reported that Ephexin1 and Ephexin5, two well-characterized Ephexin subfamily RhoGEFs, are tyrosine-phosphorylated by Src, and that their phosphorylation affect their activities and functions. In this study, we show that SGEF, but not Ephexin4, is tyrosine-phosphorylated by Src. Tyrosine phosphorylation of SGEF suppresses its interaction with RhoG, the elevation of RhoG activity, and SGEF-mediated promotion of cell migration. We identified tyrosine 530 (Y530), which is located within the Dbl homology domain, as a major phosphorylation site of SGEF by Src, and Y530F mutation blocked the inhibitory effect of Src on SGEF. Taken together, these results suggest that the activity of SGEF is negatively regulated by tyrosine phosphorylation of the DH domain.", "link"=>"http://www.mendeley.com/research/tyrosine-phosphorylation-sgef-regulates-rhog-activity-cell-migration", "reader_count"=>8, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>3, "Student > Master"=>2, "Student > Bachelor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>3, "Student > Master"=>2, "Student > Bachelor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>3, "Agricultural and Biological Sciences"=>3, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Unspecified"=>{"Unspecified"=>1}}, "group_count"=>0}

Scopus | Further Information

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