Disturbance in the Mucosa-Associated Commensal Bacteria Is Associated with the Exacerbation of Chronic Colitis by Repeated Psychological Stress; Is That the New Target of Probiotics?
Publication Date
August 08, 2016
Journal
PLOS ONE
Authors
Sohei Arase, Yohei Watanabe, Hiromi Setoyama, Noriko Nagaoka, et al
Volume
11
Issue
8
Pages
e0160736
DOI
https://dx.plos.org/10.1371/journal.pone.0160736
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0160736
Scopus
84983027816
Mendeley
http://www.mendeley.com/research/disturbance-mucosaassociated-commensal-bacteria-associated-exacerbation-chronic-colitis-repeated-psy
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Mendeley | Further Information

{"title"=>"Disturbance in the mucosa-associated commensal bacteria is associated with the exacerbation of chronic colitis by repeated psychological stress; is that the new target of probiotics?", "type"=>"journal", "authors"=>[{"first_name"=>"Sohei", "last_name"=>"Arase", "scopus_author_id"=>"57183864900"}, {"first_name"=>"Yohei", "last_name"=>"Watanabe", "scopus_author_id"=>"56429887700"}, {"first_name"=>"Hiromi", "last_name"=>"Setoyama", "scopus_author_id"=>"6701590401"}, {"first_name"=>"Noriko", "last_name"=>"Nagaoka", "scopus_author_id"=>"36817356700"}, {"first_name"=>"Mitsuhisa", "last_name"=>"Kawai", "scopus_author_id"=>"55615398200"}, {"first_name"=>"Satoshi", "last_name"=>"Matsumoto", "scopus_author_id"=>"20235207100"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84983027816", "pui"=>"611726044", "doi"=>"10.1371/journal.pone.0160736", "sgr"=>"84983027816", "pmid"=>"27500935"}, "id"=>"7c8875bd-6468-3b04-91d1-5c2aaa1f4a06", "abstract"=>"Psychological stress can exacerbate inflammatory bowel disease. However, the mechanisms underlying how psychological stress affects gut inflammation remain unclear. Here, we focused on the relationship between changes in the microbial community of mucosa-associated commensal bacteria (MACB) and mucosal immune responses induced by chronic psychological stress in a murine model of ulcerative colitis. Furthermore, we examined the effect of probiotic treatment on exacerbated colitis and MACB composition changes induced by chronic psychological stress. Repeated water avoidance stress (rWAS) in B6-Tcra-/- mice severely exacerbated colitis, which was evaluated by both colorectal tissue weight and histological score of colitis. rWAS treatment increased mRNA expression of UCN2 and IFN-γ in large intestinal lamina propria mononuclear cells (LI-LPMC). Interestingly, exacerbated colitis was associated with changes in the microbial community of MACB, specifically loss of bacterial species diversity and an increase in the component ratio of Clostridium, revealed by 16S rRNA gene amplicon analysis. Finally, the oral administration of a probiotic Lactobacillus strain was protective against the exacerbation of colitis and was associated with a change in the bacterial community of MACB in rWAS-exposed Tcra-/- mice. Taken together, these results suggested that loss of species diversity in MACB might play a key role in exacerbated colitis induced by chronic psychological stress. In addition, probiotic treatment may be used as a tool to preserve the diversity of bacterial species in MACB and alleviate gut inflammation induced by psychological stress.", "link"=>"http://www.mendeley.com/research/disturbance-mucosaassociated-commensal-bacteria-associated-exacerbation-chronic-colitis-repeated-psy", "reader_count"=>17, "reader_count_by_academic_status"=>{"Researcher"=>4, "Student > Doctoral Student"=>1, "Other"=>1, "Student > Master"=>5, "Student > Bachelor"=>5, "Professor"=>1}, "reader_count_by_user_role"=>{"Researcher"=>4, "Student > Doctoral Student"=>1, "Other"=>1, "Student > Master"=>5, "Student > Bachelor"=>5, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Biochemistry, Genetics and Molecular Biology"=>2, "Nursing and Health Professions"=>1, "Agricultural and Biological Sciences"=>5, "Medicine and Dentistry"=>4, "Psychology"=>1, "Computer Science"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>4}, "Psychology"=>{"Psychology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>5}, "Computer Science"=>{"Computer Science"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>3}}, "reader_count_by_country"=>{"Japan"=>1}, "group_count"=>1}

Scopus | Further Information

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