The First Pilot Genome-Wide Gene-Environment Study of Depression in the Japanese Population
Publication Date
August 16, 2016
Journal
PLOS ONE
Authors
Takeshi Otowa, Yoshiya Kawamura, Akizumi Tsutsumi, Norito Kawakami, et al
Volume
11
Issue
8
Pages
e0160823
DOI
https://dx.plos.org/10.1371/journal.pone.0160823
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0160823
Scopus
84984861191
Mendeley
http://www.mendeley.com/research/first-pilot-genomewide-geneenvironment-study-depression-japanese-population
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Mendeley | Further Information

{"title"=>"The first pilot genome-wide gene-environment study of depression in the Japanese population", "type"=>"journal", "authors"=>[{"first_name"=>"Takeshi", "last_name"=>"Otowa", "scopus_author_id"=>"6602179498"}, {"first_name"=>"Yoshiya", "last_name"=>"Kawamura", "scopus_author_id"=>"35310919600"}, {"first_name"=>"Akizumi", "last_name"=>"Tsutsumi", "scopus_author_id"=>"35425517500"}, {"first_name"=>"Norito", "last_name"=>"Kawakami", "scopus_author_id"=>"35377339000"}, {"first_name"=>"Chiemi", "last_name"=>"Kan", "scopus_author_id"=>"55517066300"}, {"first_name"=>"Takafumi", "last_name"=>"Shimada", "scopus_author_id"=>"35312277700"}, {"first_name"=>"Tadashi", "last_name"=>"Umekage", "scopus_author_id"=>"8057626900"}, {"first_name"=>"Kiyoto", "last_name"=>"Kasai", "scopus_author_id"=>"26643019200"}, {"first_name"=>"Katsushi", "last_name"=>"Tokunaga", "scopus_author_id"=>"55066408600"}, {"first_name"=>"Tsukasa", "last_name"=>"Sasaki", "scopus_author_id"=>"55629396800"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84984861191", "doi"=>"10.1371/journal.pone.0160823", "pmid"=>"27529621", "issn"=>"19326203", "scopus"=>"2-s2.0-84984861191", "pui"=>"611884609"}, "id"=>"ba46dbd4-c30f-3767-a021-af0f83fb32a5", "abstract"=>"Stressful events have been identified as a risk factor for depression. Although gene-environment (G +� E) interaction in a limited number of candidate genes has been explored, no genome-wide search has been reported. The aim of the present study is to identify genes that influence the association of stressful events with depression. Therefore, we performed a genome-wide G +� E interaction analysis in the Japanese population. A genome-wide screen with 320 subjects was performed using the Affymetrix Genome-Wide Human Array 6.0. Stressful life events were assessed using the Social Readjustment Rating Scale (SRRS) and depression symptoms were assessed with self-rating questionnaires using the Center for Epidemiologic Studies Depression (CES-D) scale. The p values for interactions between single nucleotide polymorphisms (SNPs) and stressful events were calculated using the linear regression model adjusted for sex and age. After quality control of genotype data, a total of 534,848 SNPs on autosomal chromosomes were further analyzed. Although none surpassed the level of the genome-wide significance, a marginal significant association of interaction between SRRS and rs10510057 with depression were found (p = 4.5 +� 10-8). The SNP is located on 10q26 near Regulators of G-protein signaling 10 (RGS10), which encodes a regulatory molecule involved in stress response. When we investigated a similar G +� E interaction between depression (K6 scale) and work-related stress in an independent sample (n = 439), a significant G +� E effect on depression was observed (p = 0.015). Our findings suggest that rs10510057, interacting with stressors, may be involved in depression risk. Incorporating G +� E interaction into GWAS can contribute to find susceptibility locus that are potentially missed by conventional GWAS.;", "link"=>"http://www.mendeley.com/research/first-pilot-genomewide-geneenvironment-study-depression-japanese-population", "reader_count"=>15, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Researcher"=>2, "Student > Ph. D. Student"=>1, "Student > Postgraduate"=>1, "Student > Master"=>4, "Other"=>2, "Student > Bachelor"=>2, "Lecturer"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Researcher"=>2, "Student > Ph. D. Student"=>1, "Student > Postgraduate"=>1, "Student > Master"=>4, "Other"=>2, "Student > Bachelor"=>2, "Lecturer"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Nursing and Health Professions"=>1, "Biochemistry, Genetics and Molecular Biology"=>2, "Agricultural and Biological Sciences"=>2, "Medicine and Dentistry"=>2, "Neuroscience"=>2, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Psychology"=>3, "Computer Science"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Neuroscience"=>{"Neuroscience"=>2}, "Psychology"=>{"Psychology"=>3}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}, "Computer Science"=>{"Computer Science"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"China"=>1, "Thailand"=>1}, "group_count"=>0}

Scopus | Further Information

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