The Anti-Inflammatory Effects of Blueberries in an Animal Model of Post-Traumatic Stress Disorder (PTSD)
Publication Date
September 07, 2016
Journal
PLOS ONE
Authors
Philip J. Ebenezer, C. Brad Wilson, Leslie D. Wilson, Anand R. Nair, et al
Volume
11
Issue
9
Pages
e0160923
DOI
https://dx.plos.org/10.1371/journal.pone.0160923
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0160923
Web of Science
000383255200009
Scopus
84992389418
Mendeley
http://www.mendeley.com/research/antiinflammatory-effects-blueberries-animal-model-posttraumatic-stress-disorder-ptsd-2
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Mendeley | Further Information

{"title"=>"The anti-inflammatory effects of blueberries in an animal model of post-traumatic stress disorder (PTSD)", "type"=>"journal", "authors"=>[{"first_name"=>"Philip J.", "last_name"=>"Ebenezer", "scopus_author_id"=>"24337882000"}, {"first_name"=>"C. Brad", "last_name"=>"Wilson", "scopus_author_id"=>"55900604400"}, {"first_name"=>"Leslie D.", "last_name"=>"Wilson", "scopus_author_id"=>"57191668683"}, {"first_name"=>"Anand R.", "last_name"=>"Nair", "scopus_author_id"=>"55552917100"}, {"first_name"=>"J.", "last_name"=>"Francis", "scopus_author_id"=>"56432093800"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84992389418", "sgr"=>"84992389418", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0160923", "pmid"=>"27603014", "isbn"=>"1932-6203", "pui"=>"612856807"}, "id"=>"fcf3bae4-3fb8-3a8c-9c08-f1b0a28029bb", "abstract"=>"Post-traumatic stress disorder (PTSD) is a trauma and stressor-related\\ndisorder that results in a prolonged stress response. It is associated\\nwith increased oxidative stress and inflammation in the prefrontal\\ncortex (PFC) and hippocampus (HC). The only approved therapy for PTSD is\\nselective serotonin re-uptake inhibitors (SSRIs), but their efficacy\\nismarginal. Recently, we demonstrated that over-production of\\nnorepinephrine (NE) as the possible reason for the lack of efficacy of\\nSSRIs. Hence, there is a need for novel therapeutic approaches for the\\ntreatment of PTSD. In this study, we investigated the anti-inflammatory\\nrole of blueberries in modulating inflammatory markers and\\nneurotransmitter levels in PTSD. Rats were fed either a blueberry\\nenriched (2%) or a control diet. Rats were exposed to cats for one hour\\non days 1 and 11 of a 31-day schedule to simulate traumatic conditions.\\nThe rats were also subjected to psychosocial stress via daily cage\\ncohort changes. At the end of the study, the rats were euthanized and\\nthe PFC and HC were isolated. Monoamines were measured by\\nhigh-performance liquid chromatography. Reactive oxygen species (ROS),\\ngene and protein expression levels of inflammatory cytokines were\\nalsomeasured. In our PTSD-model, NE levels were increased and 5-HT\\nlevels were decreased when compared to control. In contrast, a blueberry\\nenriched diet increased 5-HT without affecting NE levels. The rate\\nlimiting enzymes tyrosine hydroxylase and tryptophan hydroxylase were\\nalso studied and they confirmed our findings. The enhanced levels free\\nradicals, gene and protein expression of inflammatory cytokines seen in\\nthe PTSD group were normalized with a blueberry enriched diet. Decreased\\nanxiety in this group was shown by improved performance on the elevated\\nplus-maze. These findings indicate blueberries can attenuate oxidative\\nstress and inflammation and restore neurotransmitter imbalances in a\\nratmodel of PTSD.", "link"=>"http://www.mendeley.com/research/antiinflammatory-effects-blueberries-animal-model-posttraumatic-stress-disorder-ptsd-2", "reader_count"=>25, "reader_count_by_academic_status"=>{"Unspecified"=>4, "Researcher"=>3, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>3, "Student > Master"=>4, "Student > Bachelor"=>7, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>4, "Researcher"=>3, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>3, "Student > Master"=>4, "Student > Bachelor"=>7, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>4, "Nursing and Health Professions"=>2, "Biochemistry, Genetics and Molecular Biology"=>1, "Agricultural and Biological Sciences"=>6, "Medicine and Dentistry"=>3, "Neuroscience"=>1, "Sports and Recreations"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Psychology"=>5, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>3}, "Neuroscience"=>{"Neuroscience"=>1}, "Sports and Recreations"=>{"Sports and Recreations"=>1}, "Psychology"=>{"Psychology"=>5}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>6}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>4}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "group_count"=>1}

Scopus | Further Information

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