IL-33 Receptor-Expressing Regulatory T Cells Are Highly Activated, Th2 Biased and Suppress CD4 T Cell Proliferation through IL-10 and TGFβ Release
Publication Date
August 22, 2016
Journal
PLOS ONE
Authors
Julia Siede, Anja Fröhlich, Angeliki Datsi, Ahmed N. Hegazy, et al
Volume
11
Issue
8
Pages
e0161507
DOI
https://dx.plos.org/10.1371/journal.pone.0161507
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0161507
Web of Science
000381768400064
Scopus
84984917650
Mendeley
http://www.mendeley.com/research/il33-receptorexpressing-regulatory-t-cells-highly-activated-th2-biased-suppress-cd4-t-cell-prolifera
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Mendeley | Further Information

{"title"=>"IL-33 receptor-expressing regulatory t cells are highly activated, Th2 biased and suppress CD4 T Cell proliferation through IL-10 and TGFβ Release", "type"=>"journal", "authors"=>[{"first_name"=>"Julia", "last_name"=>"Siede", "scopus_author_id"=>"55338670100"}, {"first_name"=>"Anja", "last_name"=>"Fröhlich", "scopus_author_id"=>"14035480900"}, {"first_name"=>"Angeliki", "last_name"=>"Datsi", "scopus_author_id"=>"57190978507"}, {"first_name"=>"Ahmed N.", "last_name"=>"Hegazy", "scopus_author_id"=>"22957478600"}, {"first_name"=>"Domonkos V.", "last_name"=>"Varga", "scopus_author_id"=>"57200784642"}, {"first_name"=>"Vivien", "last_name"=>"Holecska", "scopus_author_id"=>"51061040700"}, {"first_name"=>"Hirohisa", "last_name"=>"Saito", "scopus_author_id"=>"57195496370"}, {"first_name"=>"Susumu", "last_name"=>"Nakae", "scopus_author_id"=>"7005574089"}, {"first_name"=>"Max", "last_name"=>"Löhning", "scopus_author_id"=>"6603049053"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84984917650", "doi"=>"10.1371/journal.pone.0161507", "pmid"=>"27548066", "issn"=>"19326203", "scopus"=>"2-s2.0-84984917650", "pui"=>"611884877"}, "id"=>"169caacd-7881-3dc7-865b-e18242df36e8", "abstract"=>"Immunomodulatory Foxp3 + regulatory T cells (Tregs) form a heterogeneous population consisting of subsets with different activation states, migratory properties and suppressive functions. Recently, expression of the IL-33 receptor ST2 was shown on Tregs in inflamma-tory settings. Here we report that ST2 expression identifies highly activated Tregs in mice even under homeostatic conditions. ST2 + Tregs preferentially accumulate at non-lymphoid sites, likely mediated by their high expression of several chemokine receptors facilitating tis-sue homing. ST2 + Tregs exhibit a Th2-biased character, expressing GATA-3 and producing the Th2 cytokines IL-5 and IL-13 –especially in response to IL-33. Yet, IL-33 is dispensable for the generation and maintenance of these cells in vivo. Furthermore, ST2 + Tregs are superior to ST2 − Tregs in suppressing CD4 + T cell proliferation in vitro independent of IL-33. This higher suppressive capacity is partially mediated by enhanced production and acti-vation of the anti-inflammatory cytokines IL-10 and TGFβ. Thus, ST2 expression identifies a highly activated, strongly suppressive Treg subset preferentially located in non-lymphoid tissues. Here ST2 + Tregs may be well positioned to immediately react to IL-33 alarm sig-nals. Their specific properties may render ST2 + Tregs useful targets for immunomodulatory therapies.", "link"=>"http://www.mendeley.com/research/il33-receptorexpressing-regulatory-t-cells-highly-activated-th2-biased-suppress-cd4-t-cell-prolifera", "reader_count"=>41, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Researcher"=>4, "Student > Doctoral Student"=>5, "Student > Ph. D. Student"=>15, "Student > Postgraduate"=>1, "Student > Master"=>10, "Other"=>1, "Student > Bachelor"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Researcher"=>4, "Student > Doctoral Student"=>5, "Student > Ph. D. Student"=>15, "Student > Postgraduate"=>1, "Student > Master"=>10, "Other"=>1, "Student > Bachelor"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Biochemistry, Genetics and Molecular Biology"=>6, "Medicine and Dentistry"=>5, "Agricultural and Biological Sciences"=>9, "Chemical Engineering"=>1, "Psychology"=>1, "Immunology and Microbiology"=>17}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>5}, "Psychology"=>{"Psychology"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>17}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>9}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>6}, "Unspecified"=>{"Unspecified"=>2}, "Chemical Engineering"=>{"Chemical Engineering"=>1}}, "reader_count_by_country"=>{"Japan"=>1}, "group_count"=>0}

Scopus | Further Information

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