Adjuvant treatment with the bacterial lysate (OM-85) improves management of atopic dermatitis: A randomized study
Publication Date
March 23, 2017
Authors
Christine Bodemer, Gerard Guillet, Frederic Cambazard, Franck Boralevi, et al
Volume
12
Issue
3
Pages
e0161555
DOI
https://dx.plos.org/10.1371/journal.pone.0161555
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0161555
Scopus
85016151158
Mendeley
http://www.mendeley.com/research/adjuvant-treatment-bacterial-lysate-om85-improves-management-atopic-dermatitis-randomized-study
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"Adjuvant treatment with the bacterial lysate (OM-85) improves management of atopic dermatitis: A randomized study", "type"=>"journal", "authors"=>[{"first_name"=>"Christine", "last_name"=>"Bodemer", "scopus_author_id"=>"7006485009"}, {"first_name"=>"Gerard", "last_name"=>"Guillet", "scopus_author_id"=>"8877938200"}, {"first_name"=>"Frederic", "last_name"=>"Cambazard", "scopus_author_id"=>"7102566085"}, {"first_name"=>"Franck", "last_name"=>"Boralevi", "scopus_author_id"=>"6701399495"}, {"first_name"=>"Stefania", "last_name"=>"Ballarini", "scopus_author_id"=>"56015957100"}, {"first_name"=>"Christian", "last_name"=>"Milliet", "scopus_author_id"=>"57193729512"}, {"first_name"=>"Paola", "last_name"=>"Bertuccio", "scopus_author_id"=>"8604284300"}, {"first_name"=>"Carlo", "last_name"=>"La Vecchia", "scopus_author_id"=>"36063266200"}, {"first_name"=>"Jean François", "last_name"=>"Bach", "scopus_author_id"=>"35401383400"}, {"first_name"=>"Yves", "last_name"=>"De Prost", "scopus_author_id"=>"7103057745"}], "year"=>2017, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-85016151158", "pui"=>"614970108", "sgr"=>"85016151158", "isbn"=>"1111111111", "issn"=>"19326203", "pmid"=>"28333952", "doi"=>"10.1371/journal.pone.0161555"}, "id"=>"4d33a245-68dc-32e7-b3c2-9ca7aa5db138", "abstract"=>"BACKGROUND Environmental factors play a major role on atopic dermatitis (AD) which shows a constant rise in prevalence in western countries over the last decades. The Hygiene Hypothesis suggesting an inverse relationship between incidence of infections and the increase in atopic diseases in these countries, is one of the working hypothesis proposed to explain this trend. OBJECTIVE This study tested the efficacy and safety of oral administration of the bacterial lysate OM-85 (Broncho-Vaxom®, Broncho-Munal®, Ommunal®, Paxoral®, Vaxoral®), in the treatment of established AD in children. METHODS Children aged 6 months to 7 years, with confirmed AD diagnosis, were randomized in a double-blind, placebo-controlled trial to receive, in addition to conventional treatment with emollients and topical corticosteroids, 3.5mg of the bacterial extract OM-85 or placebo daily for 9 months. The primary end-point was the difference between groups in the occurrence of new flares (NF) during the study period, evaluated by Hazard Ratio (HR) derived from conditional Cox proportional hazard regression models accounting for repeated events. RESULTS Among the 179 randomized children, 170 were analysed, 88 in the OM-85 and 82 in the placebo group. As expected most children in both treatment groups experienced at least 1 NF during the study period (75 (85%) patients in the OM-85 group and 72 (88%) in the placebo group). Patients treated with OM-85 as adjuvant therapy had significantly fewer and delayed NFs (HR of repeated flares = 0.80; 95% confidence interval (CI): 0.67-0.96), also when potential confounding factors, as family history of atopy and corticosteroids use, were taken into account (HR = 0.82; 95% CI: 0.69-0.98). No major side effect was reported, with comparable and good tolerability for OM-85 and placebo. CONCLUSIONS Results show an adjuvant therapeutic effect of a well standardized bacterial lysate OM-85 on established AD.", "link"=>"http://www.mendeley.com/research/adjuvant-treatment-bacterial-lysate-om85-improves-management-atopic-dermatitis-randomized-study", "reader_count"=>16, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Researcher"=>5, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>4, "Student > Bachelor"=>2, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Researcher"=>5, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>4, "Student > Bachelor"=>2, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Biochemistry, Genetics and Molecular Biology"=>1, "Agricultural and Biological Sciences"=>2, "Medicine and Dentistry"=>10, "Psychology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>10}, "Psychology"=>{"Psychology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>2}}, "group_count"=>0}

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/85016151158"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/85016151158?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85016151158&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85016151158&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/85016151158", "dc:identifier"=>"SCOPUS_ID:85016151158", "eid"=>"2-s2.0-85016151158", "dc:title"=>"Adjuvant treatment with the bacterial lysate (OM-85) improves management of atopic dermatitis: A randomized study", "dc:creator"=>"Bodemer C.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"12", "prism:issueIdentifier"=>"3", "prism:pageRange"=>nil, "prism:coverDate"=>"2017-03-01", "prism:coverDisplayDate"=>"March 2017", "prism:doi"=>"10.1371/journal.pone.0161555", "citedby-count"=>"2", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Hôpital Necker Enfants Malades", "affiliation-city"=>"Paris", "affiliation-country"=>"France"}], "pubmed-id"=>"28333952", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e0161555", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true}

Counter

  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"46", "xml_views"=>"5", "html_views"=>"253"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"38", "xml_views"=>"5", "html_views"=>"138"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"23", "xml_views"=>"2", "html_views"=>"94"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"71"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"38"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"22", "xml_views"=>"2", "html_views"=>"69"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"23", "xml_views"=>"2", "html_views"=>"59"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"16", "xml_views"=>"1", "html_views"=>"63"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"182"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"328"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"14", "xml_views"=>"2", "html_views"=>"56"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"46"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"33"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"14", "xml_views"=>"1", "html_views"=>"54"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"2", "html_views"=>"27"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"3", "html_views"=>"34"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"38"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"33"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"10", "xml_views"=>"2", "html_views"=>"45"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"44"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"17", "xml_views"=>"1", "html_views"=>"27"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"14", "xml_views"=>"2", "html_views"=>"26"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"23"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"19"}

PMC Usage Stats

  • {"unique-ip"=>"92", "full-text"=>"103", "pdf"=>"17", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"53", "full-text"=>"54", "pdf"=>"33", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"30", "full-text"=>"29", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"40", "full-text"=>"41", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"32", "full-text"=>"33", "pdf"=>"18", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"43", "full-text"=>"50", "pdf"=>"17", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"66", "full-text"=>"63", "pdf"=>"25", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"39", "full-text"=>"37", "pdf"=>"24", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"28", "full-text"=>"37", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"38", "full-text"=>"44", "pdf"=>"19", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"2"}
  • {"unique-ip"=>"39", "full-text"=>"43", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"8", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"31", "full-text"=>"30", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"35", "full-text"=>"29", "pdf"=>"13", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"23", "full-text"=>"28", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"32", "full-text"=>"29", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"31", "full-text"=>"34", "pdf"=>"22", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"43", "full-text"=>"46", "pdf"=>"16", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"26", "full-text"=>"31", "pdf"=>"10", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"26", "full-text"=>"26", "pdf"=>"10", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"7", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"28", "full-text"=>"28", "pdf"=>"10", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"49", "full-text"=>"48", "pdf"=>"18", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"25", "full-text"=>"24", "pdf"=>"9", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"3", "cited-by"=>"1", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"34", "full-text"=>"27", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"7", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"25", "full-text"=>"28", "pdf"=>"10", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"20", "full-text"=>"25", "pdf"=>"10", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
Loading … Spinner
There are currently no alerts