Renal Dysfunction during Tenofovir Use in a Regional Cohort of HIV-Infected Individuals in the Asia-Pacific
Publication Date
August 25, 2016
Journal
PLOS ONE
Authors
Junko Tanuma, Awachana Jiamsakul, Abhimanyu Makane, Anchalee Avihingsanon, et al
Volume
11
Issue
8
Pages
e0161562
DOI
https://dx.plos.org/10.1371/journal.pone.0161562
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0161562
Scopus
84990036805
Mendeley
http://www.mendeley.com/research/renal-dysfunction-during-tenofovir-regional-cohort-hivinfected-individuals-asiapacific
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Mendeley | Further Information

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H.", "last_name"=>"Bui", "scopus_author_id"=>"55224523000"}, {"first_name"=>"T. T.", "last_name"=>"Cao", "scopus_author_id"=>"55992422700"}, {"first_name"=>"D. D.", "last_name"=>"Cuong", "scopus_author_id"=>"55035577700"}, {"first_name"=>"H. L.", "last_name"=>"Ha", "scopus_author_id"=>"55992440100"}, {"first_name"=>"N.", "last_name"=>"Durier", "scopus_author_id"=>"24775720700"}, {"first_name"=>"B.", "last_name"=>"Petersen", "scopus_author_id"=>"56406054800"}, {"first_name"=>"T.", "last_name"=>"Singtoroj", "scopus_author_id"=>"8718338700"}, {"first_name"=>"D. A.", "last_name"=>"Cooper", "scopus_author_id"=>"36078697200"}, {"first_name"=>"M. G.", "last_name"=>"Law", "scopus_author_id"=>"55556254800"}, {"first_name"=>"D. C.", "last_name"=>"Boettiger", "scopus_author_id"=>"56352655700"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84990036805", "pmid"=>"27560968", "pui"=>"612518368", "scopus"=>"2-s2.0-84990036805", "doi"=>"10.1371/journal.pone.0161562", "issn"=>"19326203"}, "id"=>"6573aa8f-f063-3972-89ba-2cd758e02ac1", "abstract"=>"BACKGROUND In resource-limited settings, routine monitoring of renal function during antiretroviral therapy (ART) has not been recommended. However, concerns for tenofovir disoproxil fumarate (TDF)-related nephrotoxicity persist with increased use. METHODS We investigated serum creatinine (S-Cr) monitoring rates before and during ART and the incidence and prevalence of renal dysfunction after starting TDF by using data from a regional cohort of HIV-infected individuals in the Asia-Pacific. Time to renal dysfunction was defined as time from TDF initiation to the decline in estimated glomerular filtration rate (eGFR) to <60 ml/min/1.73m2 with >30% reduction from baseline using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation or the decision to stop TDF for reported TDF-nephrotoxicity. Predictors of S-Cr monitoring rates were assessed by Poisson regression and risk factors for developing renal dysfunction were assessed by Cox regression. RESULTS Among 2,425 patients who received TDF, S-Cr monitoring rates increased from 1.01 to 1.84 per person per year after starting TDF (incidence rate ratio 1.68, 95%CI 1.62-1.74, p <0.001). Renal dysfunction on TDF occurred in 103 patients over 5,368 person-years of TDF use (4.2%; incidence 1.75 per 100 person-years). Risk factors for developing renal dysfunction included older age (>50 vs. ≤30, hazard ratio [HR] 5.39, 95%CI 2.52-11.50, p <0.001; and using PI-based regimen (HR 1.93, 95%CI 1.22-3.07, p = 0.005). Having an eGFR prior to TDF (pre-TDF eGFR) of ≥60 ml/min/1.73m2 showed a protective effect (HR 0.38, 95%CI, 0.17-0.85, p = 0.018). CONCLUSIONS Renal dysfunction on commencing TDF use was not common, however, older age, lower baseline eGFR and PI-based ART were associated with higher risk of renal dysfunction during TDF use in adult HIV-infected individuals in the Asia-Pacific region.", "link"=>"http://www.mendeley.com/research/renal-dysfunction-during-tenofovir-regional-cohort-hivinfected-individuals-asiapacific", "reader_count"=>19, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Student > Doctoral Student"=>3, "Researcher"=>3, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>3, "Other"=>3, "Student > Master"=>2, "Professor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Student > Doctoral Student"=>3, "Researcher"=>3, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>3, "Other"=>3, "Student > Master"=>2, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Nursing and Health Professions"=>1, "Biochemistry, Genetics and Molecular Biology"=>1, "Agricultural and Biological Sciences"=>2, "Medicine and Dentistry"=>10, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Immunology and Microbiology"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>10}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>2}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"Australia"=>1}, "group_count"=>1}

Scopus | Further Information

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