Expression Profile of Six RNA-Binding Proteins in Pulmonary Sarcoidosis
Publication Date
August 30, 2016
Journal
PLOS ONE
Authors
Zdenka Navratilova, Eva Novosadova, Michael Hagemann Jensen, Susanna Kullberg, et al
Volume
11
Issue
8
Pages
e0161669
DOI
https://dx.plos.org/10.1371/journal.pone.0161669
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0161669
Scopus
84990224005
Mendeley
http://www.mendeley.com/research/expression-profile-six-rnabinding-proteins-pulmonary-sarcoidosis
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Mendeley | Further Information

{"title"=>"Expression profile of six RNA-binding proteins in pulmonary sarcoidosis", "type"=>"journal", "authors"=>[{"first_name"=>"Zdenka", "last_name"=>"Navratilova", "scopus_author_id"=>"24391168200"}, {"first_name"=>"Eva", "last_name"=>"Novosadova", "scopus_author_id"=>"57190296418"}, {"first_name"=>"Michael", "last_name"=>"Hagemann-Jensen", "scopus_author_id"=>"54973769500"}, {"first_name"=>"Susanna", "last_name"=>"Kullberg", "scopus_author_id"=>"57193763591"}, {"first_name"=>"Vitezslav", "last_name"=>"Kolek", "scopus_author_id"=>"7005480846"}, {"first_name"=>"Johan", "last_name"=>"Grunewald", "scopus_author_id"=>"7006499940"}, {"first_name"=>"Martin", "last_name"=>"Petrek", "scopus_author_id"=>"7003915936"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84990224005", "sgr"=>"84990224005", "doi"=>"10.1371/journal.pone.0161669", "pui"=>"612518301", "pmid"=>"27575817", "isbn"=>"1932-6203", "issn"=>"19326203"}, "id"=>"d8c40a25-9df7-3195-9be3-35f297230de3", "abstract"=>"BACKGROUND Sarcoidosis is characterised by up-regulation of cytokines and chemokine ligands/receptors and proteolytic enzymes. This pro-inflammatory profile is regulated post-transcriptionally by RNA-binding proteins (RBPs). We investigated in vivo expression of six RBPs (AUF1, HuR, NCL, TIA, TIAR, PCBP2) and two inhibitors of proteolytic enzymes (RECK, PTEN) in pulmonary sarcoidosis and compared it to the expression in four control groups of healthy individuals and patients with other respiratory diseases: chronic obstructive pulmonary disease (COPD), asthma and idiopathic interstitial pneumonias (IIPs). METHODS RT-PCR was used to quantify the mRNAs in bronchoalveolar (BA) cells obtained from 50 sarcoidosis patients, 23 healthy controls, 30 COPD, 19 asthmatic and 19 IIPs patients. Flow cytometry was used to assess intracellular protein expression of AUF1 and HuR in peripheral blood T lymphocytes (PBTLs) obtained from 9 sarcoidosis patients and 6 healthy controls. RESULTS Taking the stringent conditions for multiple comparisons into consideration, we consistently observed in the primary analysis including all patients regardless of smoking status as well as in the subsequent sub-analysis limited for never smokers that the BA mRNA expression of AUF1 (p<0.001), TIA (p<0.001), NCL (p<0.01) and RECK (p<0.05) was decreased in sarcoidosis compared to healthy controls. TIA mRNA was also decreased in sarcoidosis compared to both obstructive pulmonary diseases (COPD and asthma; p<0.001) but not compared to IIPs. There were several positive correlations between RECK mRNA and RBP mRNAs in BA cells. Also sarcoidosis CD3+, CD4+ and CD8+ PBTLs displayed lower mean fluorescence intensity of AUF1 (p≤0.02) and HuR (p≤0.03) proteins than control healthy PBTLs. CONCLUSION mRNA expressions of three RBPs (AUF1, TIA and NCL) and their potential target mRNA encoding RECK in BA cells and additionally protein expression of AUF1 and HuR in PBTLs were down-regulated in our sarcoidosis patients compared to healthy individuals. Its significance, e.g. for stability of mRNAs encoding pro-inflammatory factors, should be further explored in sarcoidosis.", "link"=>"http://www.mendeley.com/research/expression-profile-six-rnabinding-proteins-pulmonary-sarcoidosis", "reader_count"=>3, "reader_count_by_academic_status"=>{"Student > Ph. D. Student"=>1, "Student > Master"=>1, "Other"=>1}, "reader_count_by_user_role"=>{"Student > Ph. D. Student"=>1, "Student > Master"=>1, "Other"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>1, "Agricultural and Biological Sciences"=>1, "Medicine and Dentistry"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}}, "group_count"=>0}

Scopus | Further Information

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